BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

151 related articles for article (PubMed ID: 38635934)

  • 1. Randomized Phase II Study of Gemcitabine With or Without ATR Inhibitor Berzosertib in Platinum-Resistant Ovarian Cancer: Final Overall Survival and Biomarker Analyses.
    Konstantinopoulos PA; Cheng SC; Lee EK; da Costa AABA; Gulhan D; Wahner Hendrickson AE; Kochupurakkal B; Kolin DL; Kohn EC; Liu JF; Penson RT; Stover EH; Curtis J; Sawyer H; Polak M; Chowdhury D; D'Andrea AD; Färkkilä A; Shapiro GI; Matulonis UA
    JCO Precis Oncol; 2024 Apr; 8():e2300635. PubMed ID: 38635934
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial.
    Konstantinopoulos PA; Cheng SC; Wahner Hendrickson AE; Penson RT; Schumer ST; Doyle LA; Lee EK; Kohn EC; Duska LR; Crispens MA; Olawaiye AB; Winer IS; Barroilhet LM; Fu S; McHale MT; Schilder RJ; Färkkilä A; Chowdhury D; Curtis J; Quinn RS; Bowes B; D'Andrea AD; Shapiro GI; Matulonis UA
    Lancet Oncol; 2020 Jul; 21(7):957-968. PubMed ID: 32553118
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer.
    Konstantinopoulos PA; da Costa AABA; Gulhan D; Lee EK; Cheng SC; Hendrickson AEW; Kochupurakkal B; Kolin DL; Kohn EC; Liu JF; Stover EH; Curtis J; Tayob N; Polak M; Chowdhury D; Matulonis UA; Färkkilä A; D'Andrea AD; Shapiro GI
    Nat Commun; 2021 Sep; 12(1):5574. PubMed ID: 34552099
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of Cisplatin and Gemcitabine With or Without Berzosertib in Patients With Advanced Urothelial Carcinoma: A Phase 2 Randomized Clinical Trial.
    Pal SK; Frankel PH; Mortazavi A; Milowsky M; Vaishampayan U; Parikh M; Lyou Y; Weng P; Parikh R; Teply B; Dreicer R; Emamekhoo H; Michaelson D; Hoimes C; Zhang T; Srinivas S; Kim WY; Cui Y; Newman E; Lara PN
    JAMA Oncol; 2021 Oct; 7(10):1536-1543. PubMed ID: 34436521
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung cancer.
    Plummer R; Dean E; Arkenau HT; Redfern C; Spira AI; Melear JM; Chung KY; Ferrer-Playan J; Goddemeier T; Locatelli G; Dong J; Fleuranceau-Morel P; Diaz-Padilla I; Shapiro GI
    Lung Cancer; 2022 Jan; 163():19-26. PubMed ID: 34894455
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
    Takahashi N; Hao Z; Villaruz LC; Zhang J; Ruiz J; Petty WJ; Mamdani H; Riess JW; Nieva J; Pachecho JM; Fuld AD; Shum E; Chauhan A; Nichols S; Shimellis H; McGlone J; Sciuto L; Pinkiert D; Graham C; Shelat M; Kattappuram R; Abel M; Schroeder B; Upadhyay D; Krishnamurthy M; Sharma AK; Kumar R; Malin J; Schultz CW; Goyal S; Redon CE; Pommier Y; Aladjem MI; Gore SD; Steinberg SM; Vilimas R; Desai P; Thomas A
    JAMA Oncol; 2023 Dec; 9(12):1669-1677. PubMed ID: 37824137
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours.
    Middleton MR; Dean E; Evans TRJ; Shapiro GI; Pollard J; Hendriks BS; Falk M; Diaz-Padilla I; Plummer R
    Br J Cancer; 2021 Aug; 125(4):510-519. PubMed ID: 34040175
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.
    Terranova N; Jansen M; Falk M; Hendriks BS
    Cancer Chemother Pharmacol; 2021 Feb; 87(2):185-196. PubMed ID: 33145616
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Patient-reported outcomes and final overall survival results from the randomized phase 3 PENELOPE trial evaluating pertuzumab in low tumor human epidermal growth factor receptor 3 (HER3) mRNA-expressing platinum-resistant ovarian cancer.
    Lorusso D; Hilpert F; González Martin A; Rau J; Ottevanger P; Greimel E; Lück HJ; Selle F; Colombo N; Kroep JR; Mirza MR; Berger R; Pardo B; Grischke EM; Berton-Rigaud D; Martinez-Garcia J; Vergote I; Redondo A; Cardona A; Bastière-Truchot L; du Bois A; Kurzeder C;
    Int J Gynecol Cancer; 2019 Sep; 29(7):1141-1147. PubMed ID: 31420414
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Adavosertib plus gemcitabine for platinum-resistant or platinum-refractory recurrent ovarian cancer: a double-blind, randomised, placebo-controlled, phase 2 trial.
    Lheureux S; Cristea MC; Bruce JP; Garg S; Cabanero M; Mantia-Smaldone G; Olawaiye AB; Ellard SL; Weberpals JI; Wahner Hendrickson AE; Fleming GF; Welch S; Dhani NC; Stockley T; Rath P; Karakasis K; Jones GN; Jenkins S; Rodriguez-Canales J; Tracy M; Tan Q; Bowering V; Udagani S; Wang L; Kunos CA; Chen E; Pugh TJ; Oza AM
    Lancet; 2021 Jan; 397(10271):281-292. PubMed ID: 33485453
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A randomized, double-blind, placebo-controlled phase 1b/2 study of ralimetinib, a p38 MAPK inhibitor, plus gemcitabine and carboplatin versus gemcitabine and carboplatin for women with recurrent platinum-sensitive ovarian cancer.
    Vergote I; Heitz F; Buderath P; Powell M; Sehouli J; Lee CM; Hamilton A; Fiorica J; Moore KN; Teneriello M; Golden L; Zhang W; Pitou C; Bell R; Campbell R; Farrington DL; Bell-McGuinn K; Wenham RM
    Gynecol Oncol; 2020 Jan; 156(1):23-31. PubMed ID: 31791552
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nivolumab Versus Gemcitabine or Pegylated Liposomal Doxorubicin for Patients With Platinum-Resistant Ovarian Cancer: Open-Label, Randomized Trial in Japan (NINJA).
    Hamanishi J; Takeshima N; Katsumata N; Ushijima K; Kimura T; Takeuchi S; Matsumoto K; Ito K; Mandai M; Nakai H; Sakuragi N; Watari H; Takahashi N; Kato H; Hasegawa K; Yonemori K; Mizuno M; Takehara K; Niikura H; Sawasaki T; Nakao S; Saito T; Enomoto T; Nagase S; Suzuki N; Matsumoto T; Kondo E; Sonoda K; Aihara S; Aoki Y; Okamoto A; Takano H; Kobayashi H; Kato H; Terai Y; Takazawa A; Takahashi Y; Namba Y; Aoki D; Fujiwara K; Sugiyama T; Konishi I
    J Clin Oncol; 2021 Nov; 39(33):3671-3681. PubMed ID: 34473544
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A randomized phase II evaluation of weekly gemcitabine plus pazopanib versus weekly gemcitabine alone in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma.
    Duska LR; Petroni GR; Varhegyi N; Brown J; Jelovac D; Moore KN; McGuire WP; Darus C; Barroilhet LM; Secord AA
    Gynecol Oncol; 2020 Jun; 157(3):585-592. PubMed ID: 32247603
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Randomized phase II study of the PDGFRα antibody olaratumab plus liposomal doxorubicin versus liposomal doxorubicin alone in patients with platinum-refractory or platinum-resistant advanced ovarian cancer.
    McGuire WP; Penson RT; Gore M; Herraez AC; Peterson P; Shahir A; Ilaria R
    BMC Cancer; 2018 Dec; 18(1):1292. PubMed ID: 30591028
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The combination of gemcitabine and carboplatin shows similar efficacy in the treatment of platinum-resistant and platinum-sensitive recurrent epithelial ovarian cancer patients.
    Safra T; Asna N; Veizman A; Shpigel S; Matcejevsky D; Inbar M; Grisaru D
    Anticancer Drugs; 2014 Mar; 25(3):340-5. PubMed ID: 24185383
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Epidermal growth factor receptor blockers for the treatment of ovarian cancer.
    Haldar K; Gaitskell K; Bryant A; Nicum S; Kehoe S; Morrison J
    Cochrane Database Syst Rev; 2011 Oct; (10):CD007927. PubMed ID: 21975775
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dendritic cell-based immunotherapy (DCVAC/OvCa) combined with second-line chemotherapy in platinum-sensitive ovarian cancer (SOV02): A randomized, open-label, phase 2 trial.
    Cibula D; Rob L; Mallmann P; Knapp P; Klat J; Chovanec J; Minar L; Melichar B; Hein A; Kieszko D; Pluta M; Spacek J; Bartos P; Wimberger P; Madry R; Markowska J; Streb J; Valha P; Hassan HIB; Pecen L; Galluzzi L; Fucikova J; Hrnciarova T; Hraska M; Bartunkova J; Spisek R
    Gynecol Oncol; 2021 Sep; 162(3):652-660. PubMed ID: 34294416
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy.
    Gorecki L; Andrs M; Rezacova M; Korabecny J
    Pharmacol Ther; 2020 Jun; 210():107518. PubMed ID: 32109490
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer.
    Tattersall A; Ryan N; Wiggans AJ; Rogozińska E; Morrison J
    Cochrane Database Syst Rev; 2022 Feb; 2(2):CD007929. PubMed ID: 35170751
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.
    Dunlop CR; Wallez Y; Johnson TI; Bernaldo de Quirós Fernández S; Durant ST; Cadogan EB; Lau A; Richards FM; Jodrell DI
    Br J Cancer; 2020 Oct; 123(9):1424-1436. PubMed ID: 32741974
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.