These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
131 related articles for article (PubMed ID: 38651495)
1. Discovery of Novel Dual Inhibitors Targeting Mutant IDH1 and NAMPT for the Treatment of Glioma with IDH1Mutation. Wen F; Gui G; Wang X; Qin A; Ma T; Chen H; Li C; Zha X J Med Chem; 2024 Jun; 67(11):8667-8692. PubMed ID: 38651495 [TBL] [Abstract][Full Text] [Related]
2. Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration. Cao H; Zhu G; Sun L; Chen G; Ma X; Luo X; Zhu J Eur J Med Chem; 2019 Dec; 183():111694. PubMed ID: 31561044 [TBL] [Abstract][Full Text] [Related]
3. Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. Liu Z; Yao Y; Kogiso M; Zheng B; Deng L; Qiu JJ; Dong S; Lv H; Gallo JM; Li XN; Song Y J Med Chem; 2014 Oct; 57(20):8307-18. PubMed ID: 25271760 [TBL] [Abstract][Full Text] [Related]
4. Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion. Tateishi K; Wakimoto H; Iafrate AJ; Tanaka S; Loebel F; Lelic N; Wiederschain D; Bedel O; Deng G; Zhang B; He T; Shi X; Gerszten RE; Zhang Y; Yeh JJ; Curry WT; Zhao D; Sundaram S; Nigim F; Koerner MVA; Ho Q; Fisher DE; Roider EM; Kemeny LV; Samuels Y; Flaherty KT; Batchelor TT; Chi AS; Cahill DP Cancer Cell; 2015 Dec; 28(6):773-784. PubMed ID: 26678339 [TBL] [Abstract][Full Text] [Related]
5. Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer. Zhang W; Zhang K; Yao Y; Liu Y; Ni Y; Liao C; Tu Z; Qiu Y; Wang D; Chen D; Qiang L; Li Z; Jiang S Eur J Med Chem; 2021 Feb; 211():113022. PubMed ID: 33239261 [TBL] [Abstract][Full Text] [Related]
6. Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. Dong G; Chen W; Wang X; Yang X; Xu T; Wang P; Zhang W; Rao Y; Miao C; Sheng C J Med Chem; 2017 Oct; 60(19):7965-7983. PubMed ID: 28885834 [TBL] [Abstract][Full Text] [Related]
7. Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study. Xu T; Yang J; Li D; Challa M; Zou C; Deng P; Zhang SL; Xu B Eur J Med Chem; 2024 Sep; 275():116610. PubMed ID: 38896992 [TBL] [Abstract][Full Text] [Related]
8. Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model. Clausing M; William D; Preussler M; Biedermann J; Grützmann K; Richter S; Buchholz F; Temme A; Schröck E; Klink B Int J Mol Sci; 2022 May; 23(10):. PubMed ID: 35628596 [TBL] [Abstract][Full Text] [Related]
9. Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening. Zou F; Pusch S; Hua J; Ma T; Yang L; Zhu Q; Xu Y; Gu Y; von Deimling A; Zha X Bioorg Med Chem Lett; 2018 Feb; 28(3):388-393. PubMed ID: 29290542 [TBL] [Abstract][Full Text] [Related]
10. Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities. Bai J; Liao C; Liu Y; Qin X; Chen J; Qiu Y; Qin D; Li Z; Tu ZC; Jiang S J Med Chem; 2016 Jun; 59(12):5766-79. PubMed ID: 27224875 [TBL] [Abstract][Full Text] [Related]
11. Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies. Clark DE; Waszkowycz B; Wong M; Lockey PM; Adalbert R; Gilley J; Clark J; Coleman MP Bioorg Med Chem Lett; 2016 Jun; 26(12):2920-2926. PubMed ID: 27158141 [TBL] [Abstract][Full Text] [Related]
12. Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer. Wu F; Cheng G; Yao Y; Kogiso M; Jiang H; Li XN; Song Y Med Chem; 2018; 14(7):715-724. PubMed ID: 29792149 [TBL] [Abstract][Full Text] [Related]
13. Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma. Lin L; Cai J; Tan Z; Meng X; Li R; Li Y; Jiang C Cancer Res Treat; 2021 Apr; 53(2):367-377. PubMed ID: 33070553 [TBL] [Abstract][Full Text] [Related]
15. Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma. Yin C; Jia S; Yang X; Wu L Eur J Med Chem; 2024 May; 271():116444. PubMed ID: 38691889 [TBL] [Abstract][Full Text] [Related]
16. Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Zheng X; Baumeister T; Buckmelter AJ; Caligiuri M; Clodfelter KH; Han B; Ho YC; Kley N; Lin J; Reynolds DJ; Sharma G; Smith CC; Wang Z; Dragovich PS; Oh A; Wang W; Zak M; Wang Y; Yuen PW; Bair KW Bioorg Med Chem Lett; 2014 Jan; 24(1):337-43. PubMed ID: 24279990 [TBL] [Abstract][Full Text] [Related]
17. Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo. Pusch S; Krausert S; Fischer V; Balss J; Ott M; Schrimpf D; Capper D; Sahm F; Eisel J; Beck AC; Jugold M; Eichwald V; Kaulfuss S; Panknin O; Rehwinkel H; Zimmermann K; Hillig RC; Guenther J; Toschi L; Neuhaus R; Haegebart A; Hess-Stumpp H; Bauser M; Wick W; Unterberg A; Herold-Mende C; Platten M; von Deimling A Acta Neuropathol; 2017 Apr; 133(4):629-644. PubMed ID: 28124097 [TBL] [Abstract][Full Text] [Related]
18. IDH Inhibitors Target Common Glioma Mutation. Cancer Discov; 2019 Aug; 9(8):992. PubMed ID: 31217295 [TBL] [Abstract][Full Text] [Related]
19. Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction. Zhou X; Zheng M; Zhao N; Hu Y; Yang K; Huo J; Liu G; Huang J; Chen L; Zhou Y; Li H Bioorg Chem; 2022 Feb; 119():105569. PubMed ID: 34954572 [TBL] [Abstract][Full Text] [Related]
20. Targeting NAD Metabolism: Rational Design, Synthesis and In Vitro Evaluation of NAMPT/PARP1 Dual-Target Inhibitors as Anti-Breast Cancer Agents. Li Y; Kong X; Chu X; Fu H; Feng X; Zhao C; Deng Y; Ge J Molecules; 2024 Jun; 29(12):. PubMed ID: 38930900 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]