212 related articles for article (PubMed ID: 38683753)
21. Targeting CYP51 for drug design by the contributions of molecular modeling.
Rabelo VW; Santos TF; Terra L; Santana MV; Castro HC; Rodrigues CR; Abreu PA
Fundam Clin Pharmacol; 2017 Feb; 31(1):37-53. PubMed ID: 27487199
[TBL] [Abstract][Full Text] [Related]
22. Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa.
Warrilow AG; Price CL; Parker JE; Rolley NJ; Smyrniotis CJ; Hughes DD; Thoss V; Nes WD; Kelly DE; Holman TR; Kelly SL
Sci Rep; 2016 Jun; 6():27690. PubMed ID: 27291783
[TBL] [Abstract][Full Text] [Related]
23. Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.
Sagatova AA; Keniya MV; Tyndall JDA; Monk BC
Antimicrob Agents Chemother; 2018 Mar; 62(3):. PubMed ID: 29263059
[TBL] [Abstract][Full Text] [Related]
24. Recent advances in antifungal drug development targeting lanosterol 14α-demethylase (CYP51): A comprehensive review with structural and molecular insights.
Singh A; Singh K; Sharma A; Kaur K; Chadha R; Bedi PMS
Chem Biol Drug Des; 2023 Sep; 102(3):606-639. PubMed ID: 37220949
[TBL] [Abstract][Full Text] [Related]
25. Sterol 14α-Demethylase from Trypanosomatidae Parasites as a Promising Target for Designing New Antiparasitic Agents.
da Silva Santos-Júnior PF; Schmitt M; de Araújo-Júnior JX; da Silva-Júnior EF
Curr Top Med Chem; 2021; 21(21):1900-1921. PubMed ID: 33655860
[TBL] [Abstract][Full Text] [Related]
26. Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design.
Monk BC; Sagatova AA; Hosseini P; Ruma YN; Wilson RK; Keniya MV
Biochim Biophys Acta Proteins Proteom; 2020 Mar; 1868(3):140206. PubMed ID: 30851431
[TBL] [Abstract][Full Text] [Related]
27. Relaxed Substrate Requirements of Sterol 14α-Demethylase from
Hargrove TY; Wawrzak Z; Rachakonda G; Nes WD; Villalta F; Guengerich FP; Lepesheva GI
J Med Chem; 2021 Dec; 64(23):17511-17522. PubMed ID: 34842434
[No Abstract] [Full Text] [Related]
28. Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors.
Leaver DJ
Molecules; 2018 Jul; 23(7):. PubMed ID: 30018257
[TBL] [Abstract][Full Text] [Related]
29. Design and optimization of highly-selective fungal CYP51 inhibitors.
Hoekstra WJ; Garvey EP; Moore WR; Rafferty SW; Yates CM; Schotzinger RJ
Bioorg Med Chem Lett; 2014 Aug; 24(15):3455-8. PubMed ID: 24948565
[TBL] [Abstract][Full Text] [Related]
30. Homology modeling and screening of new 14α-demethylase inhibitor (DMI) fungicides based on optimized expression of CYP51 from Ustilago maydis in Escherichia coli.
Han R; Zhang J; Li S; Cao S; Geng H; Yuan Y; Xiao W; Liu S; Liu D
J Agric Food Chem; 2010 Dec; 58(24):12810-6. PubMed ID: 21090752
[TBL] [Abstract][Full Text] [Related]
31. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase.
Morrison AM; Goldstone JV; Lamb DC; Kubota A; Lemaire B; Stegeman JJ
Biochim Biophys Acta; 2014 Jun; 1840(6):1825-36. PubMed ID: 24361620
[TBL] [Abstract][Full Text] [Related]
32. Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Podust LM; Poulos TL; Waterman MR
Proc Natl Acad Sci U S A; 2001 Mar; 98(6):3068-73. PubMed ID: 11248033
[TBL] [Abstract][Full Text] [Related]
33. Novel mannopyranoside esters as sterol 14α-demethylase inhibitors: Synthesis, PASS predication, molecular docking, and pharmacokinetic studies.
Matin MM; Chakraborty P; Alam MS; Islam MM; Hanee U
Carbohydr Res; 2020 Oct; 496():108130. PubMed ID: 32863019
[TBL] [Abstract][Full Text] [Related]
34. Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51.
Hargrove TY; Wawrzak Z; Fisher PM; Child SA; Nes WD; Guengerich FP; Waterman MR; Lepesheva GI
J Biol Chem; 2018 Dec; 293(50):19344-19353. PubMed ID: 30327430
[TBL] [Abstract][Full Text] [Related]
35. Cytochrome P450 lanosterol 14α-demethylase (CYP51): insights from molecular genetic analysis of the ERG11 gene in Saccharomyces cerevisiae.
Loper JC
J Steroid Biochem Mol Biol; 1992 Dec; 43(8):1107-16. PubMed ID: 22217856
[TBL] [Abstract][Full Text] [Related]
36. Design, Synthesis, Bioactive Evaluation, and Molecular Dynamics Simulation of Novel 4
Bao A; Jiang W; Xie X; Wang D; Deng Z; Wang J; Li W; Tang X; Yan Y
J Med Chem; 2024 May; 67(10):7954-7972. PubMed ID: 38703119
[TBL] [Abstract][Full Text] [Related]
37.
Singh G
Curr Drug Discov Technol; 2022; 19(6):e150622206033. PubMed ID: 35708080
[TBL] [Abstract][Full Text] [Related]
38. Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors.
Stana A; Vodnar DC; Tamaian R; Pîrnău A; Vlase L; Ionuț I; Oniga O; Tiperciuc B
Int J Mol Sci; 2017 Jan; 18(1):. PubMed ID: 28106743
[TBL] [Abstract][Full Text] [Related]
39. Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.
Hoekstra WJ; Hargrove TY; Wawrzak Z; da Gama Jaen Batista D; da Silva CF; Nefertiti AS; Rachakonda G; Schotzinger RJ; Villalta F; Soeiro Mde N; Lepesheva GI
Antimicrob Agents Chemother; 2016 Feb; 60(2):1058-66. PubMed ID: 26643331
[TBL] [Abstract][Full Text] [Related]
40. Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.
Han G; Liu N; Li C; Tu J; Li Z; Sheng C
J Med Chem; 2020 May; 63(10):5341-5359. PubMed ID: 32347094
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]