BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 38689083)

  • 1. Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury.
    Feng Y; Feng Y; Gu L; Mo W; Wang X; Song B; Hong M; Geng F; Huang P; Yang H; Zhu W; Jiao Y; Zhang Q; Ding WQ; Cao J; Zhang S
    Exp Mol Med; 2024 May; 56(5):1107-1122. PubMed ID: 38689083
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.
    Chuaiphichai S; Chu SM; Carnicer R; Kelly M; Bendall JK; Simon JN; Douglas G; Crabtree MJ; Casadei B; Channon KM
    Am J Physiol Heart Circ Physiol; 2023 Apr; 324(4):H430-H442. PubMed ID: 36735402
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Nrf2/GCH1/BH4 Axis Ameliorates Radiation-Induced Skin Injury by Modulating the ROS Cascade.
    Xue J; Yu C; Sheng W; Zhu W; Luo J; Zhang Q; Yang H; Cao H; Wang W; Zhou J; Wu J; Cao P; Chen M; Ding WQ; Cao J; Zhang S
    J Invest Dermatol; 2017 Oct; 137(10):2059-2068. PubMed ID: 28596000
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
    Chuaiphichai S; Crabtree MJ; Mcneill E; Hale AB; Trelfa L; Channon KM; Douglas G
    Br J Pharmacol; 2017 Apr; 174(8):657-671. PubMed ID: 28128438
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
    McNeill E; Crabtree MJ; Sahgal N; Patel J; Chuaiphichai S; Iqbal AJ; Hale AB; Greaves DR; Channon KM
    Free Radic Biol Med; 2015 Feb; 79():206-16. PubMed ID: 25451639
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mast cell tetrahydrobiopterin contributes to itch in mice.
    Zschiebsch K; Fischer C; Wilken-Schmitz A; Geisslinger G; Channon K; Watschinger K; Tegeder I
    J Cell Mol Med; 2019 Feb; 23(2):985-1000. PubMed ID: 30450838
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
    Chuaiphichai S; McNeill E; Douglas G; Crabtree MJ; Bendall JK; Hale AB; Alp NJ; Channon KM
    Hypertension; 2014 Sep; 64(3):530-40. PubMed ID: 24777984
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.
    Hussein D; Starr A; Heikal L; McNeill E; Channon KM; Brown PR; Sutton BJ; McDonnell JM; Nandi M
    Br J Pharmacol; 2015 Aug; 172(16):4146-57. PubMed ID: 26014146
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo.
    Yin YL; Chen Y; Ren F; Wang L; Zhu ML; Lu JX; Wang QQ; Lu CB; Liu C; Bai YP; Wang SX; Wang JZ; Li P
    Redox Biol; 2022 Dec; 58():102540. PubMed ID: 36399957
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
    Adlam D; Herring N; Douglas G; De Bono JP; Li D; Danson EJ; Tatham A; Lu CJ; Jennings KA; Cragg SJ; Casadei B; Paterson DJ; Channon KM
    Cardiovasc Res; 2012 Mar; 93(4):694-701. PubMed ID: 22241166
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
    McNeill E; Stylianou E; Crabtree MJ; Harrington-Kandt R; Kolb AL; Diotallevi M; Hale AB; Bettencourt P; Tanner R; O'Shea MK; Matsumiya M; Lockstone H; Müller J; Fletcher HA; Greaves DR; McShane H; Channon KM
    Nat Commun; 2018 Dec; 9(1):5409. PubMed ID: 30573728
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.
    Cronin SJF; Rao S; Tejada MA; Turnes BL; Licht-Mayer S; Omura T; Brenneis C; Jacobs E; Barrett L; Latremoliere A; Andrews N; Channon KM; Latini A; Arvanites AC; Davidow LS; Costigan M; Rubin LL; Penninger JM; Woolf CJ
    Sci Transl Med; 2022 Aug; 14(660):eabj1531. PubMed ID: 36044597
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview.
    Nagatsu T
    J Neural Transm (Vienna); 2024 Jun; 131(6):617-630. PubMed ID: 37638996
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mechanisms underlying the efficacy and limitation of dopa and tetrahydrobiopterin therapies for the deficiency of GTP cyclohydrolase 1 revealed in a novel mouse model.
    Jiang X; Shao Y; Liao Y; Zheng X; Peng M; Cai Y; Wang M; Liu H; Zeng C; Lin Y; Zhang W; Liu L
    Eur J Pharmacol; 2024 Mar; 967():176379. PubMed ID: 38342361
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
    Douglas G; Hale AB; Crabtree MJ; Ryan BJ; Hansler A; Watschinger K; Gross SS; Lygate CA; Alp NJ; Channon KM
    Dev Biol; 2015 Mar; 399(1):129-138. PubMed ID: 25557619
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
    Carnicer R; Hale AB; Suffredini S; Liu X; Reilly S; Zhang MH; Surdo NC; Bendall JK; Crabtree MJ; Lim GB; Alp NJ; Channon KM; Casadei B
    Circ Res; 2012 Aug; 111(6):718-27. PubMed ID: 22798524
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
    Alp NJ; Mussa S; Khoo J; Cai S; Guzik T; Jefferson A; Goh N; Rockett KA; Channon KM
    J Clin Invest; 2003 Sep; 112(5):725-35. PubMed ID: 12952921
    [TBL] [Abstract][Full Text] [Related]  

  • 18. GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner.
    Wang Z; Zhang N; Zhang M; Jiang Y; Ng AS; Bridges E; Zhang W; Zeng X; Luo Q; Liang J; Győrffy B; Hublitz P; Liang Z; Fischer R; Kerr D; Harris AL; Cai S
    Cancer Res; 2023 Oct; 83(20):3400-3413. PubMed ID: 37463466
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ionizing radiation induces BH
    Yan T; Zhang T; Mu W; Qi Y; Guo S; Hu N; Zhao W; Zhang S; Wang Q; Shi L; Liu L
    Biochem Pharmacol; 2020 Oct; 180():114102. PubMed ID: 32562786
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin.
    Berbee M; Fu Q; Boerma M; Pathak R; Zhou D; Kumar KS; Hauer-Jensen M
    Int J Radiat Oncol Biol Phys; 2011 Mar; 79(3):884-91. PubMed ID: 20950957
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.