195 related articles for article (PubMed ID: 38689083)
1. Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury.
Feng Y; Feng Y; Gu L; Mo W; Wang X; Song B; Hong M; Geng F; Huang P; Yang H; Zhu W; Jiao Y; Zhang Q; Ding WQ; Cao J; Zhang S
Exp Mol Med; 2024 May; 56(5):1107-1122. PubMed ID: 38689083
[TBL] [Abstract][Full Text] [Related]
2. Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.
Chuaiphichai S; Chu SM; Carnicer R; Kelly M; Bendall JK; Simon JN; Douglas G; Crabtree MJ; Casadei B; Channon KM
Am J Physiol Heart Circ Physiol; 2023 Apr; 324(4):H430-H442. PubMed ID: 36735402
[TBL] [Abstract][Full Text] [Related]
3. The Nrf2/GCH1/BH4 Axis Ameliorates Radiation-Induced Skin Injury by Modulating the ROS Cascade.
Xue J; Yu C; Sheng W; Zhu W; Luo J; Zhang Q; Yang H; Cao H; Wang W; Zhou J; Wu J; Cao P; Chen M; Ding WQ; Cao J; Zhang S
J Invest Dermatol; 2017 Oct; 137(10):2059-2068. PubMed ID: 28596000
[TBL] [Abstract][Full Text] [Related]
4. A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
Chuaiphichai S; Crabtree MJ; Mcneill E; Hale AB; Trelfa L; Channon KM; Douglas G
Br J Pharmacol; 2017 Apr; 174(8):657-671. PubMed ID: 28128438
[TBL] [Abstract][Full Text] [Related]
5. Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
McNeill E; Crabtree MJ; Sahgal N; Patel J; Chuaiphichai S; Iqbal AJ; Hale AB; Greaves DR; Channon KM
Free Radic Biol Med; 2015 Feb; 79():206-16. PubMed ID: 25451639
[TBL] [Abstract][Full Text] [Related]
6. Mast cell tetrahydrobiopterin contributes to itch in mice.
Zschiebsch K; Fischer C; Wilken-Schmitz A; Geisslinger G; Channon K; Watschinger K; Tegeder I
J Cell Mol Med; 2019 Feb; 23(2):985-1000. PubMed ID: 30450838
[TBL] [Abstract][Full Text] [Related]
7. Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Chuaiphichai S; McNeill E; Douglas G; Crabtree MJ; Bendall JK; Hale AB; Alp NJ; Channon KM
Hypertension; 2014 Sep; 64(3):530-40. PubMed ID: 24777984
[TBL] [Abstract][Full Text] [Related]
8. Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.
Hussein D; Starr A; Heikal L; McNeill E; Channon KM; Brown PR; Sutton BJ; McDonnell JM; Nandi M
Br J Pharmacol; 2015 Aug; 172(16):4146-57. PubMed ID: 26014146
[TBL] [Abstract][Full Text] [Related]
9. Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo.
Yin YL; Chen Y; Ren F; Wang L; Zhu ML; Lu JX; Wang QQ; Lu CB; Liu C; Bai YP; Wang SX; Wang JZ; Li P
Redox Biol; 2022 Dec; 58():102540. PubMed ID: 36399957
[TBL] [Abstract][Full Text] [Related]
10. Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Adlam D; Herring N; Douglas G; De Bono JP; Li D; Danson EJ; Tatham A; Lu CJ; Jennings KA; Cragg SJ; Casadei B; Paterson DJ; Channon KM
Cardiovasc Res; 2012 Mar; 93(4):694-701. PubMed ID: 22241166
[TBL] [Abstract][Full Text] [Related]
11. Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
McNeill E; Stylianou E; Crabtree MJ; Harrington-Kandt R; Kolb AL; Diotallevi M; Hale AB; Bettencourt P; Tanner R; O'Shea MK; Matsumiya M; Lockstone H; Müller J; Fletcher HA; Greaves DR; McShane H; Channon KM
Nat Commun; 2018 Dec; 9(1):5409. PubMed ID: 30573728
[TBL] [Abstract][Full Text] [Related]
12. Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.
Cronin SJF; Rao S; Tejada MA; Turnes BL; Licht-Mayer S; Omura T; Brenneis C; Jacobs E; Barrett L; Latremoliere A; Andrews N; Channon KM; Latini A; Arvanites AC; Davidow LS; Costigan M; Rubin LL; Penninger JM; Woolf CJ
Sci Transl Med; 2022 Aug; 14(660):eabj1531. PubMed ID: 36044597
[TBL] [Abstract][Full Text] [Related]
13. Mechanisms underlying the efficacy and limitation of dopa and tetrahydrobiopterin therapies for the deficiency of GTP cyclohydrolase 1 revealed in a novel mouse model.
Jiang X; Shao Y; Liao Y; Zheng X; Peng M; Cai Y; Wang M; Liu H; Zeng C; Lin Y; Zhang W; Liu L
Eur J Pharmacol; 2024 Mar; 967():176379. PubMed ID: 38342361
[TBL] [Abstract][Full Text] [Related]
14. A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
Douglas G; Hale AB; Crabtree MJ; Ryan BJ; Hansler A; Watschinger K; Gross SS; Lygate CA; Alp NJ; Channon KM
Dev Biol; 2015 Mar; 399(1):129-138. PubMed ID: 25557619
[TBL] [Abstract][Full Text] [Related]
15. Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
Carnicer R; Hale AB; Suffredini S; Liu X; Reilly S; Zhang MH; Surdo NC; Bendall JK; Crabtree MJ; Lim GB; Alp NJ; Channon KM; Casadei B
Circ Res; 2012 Aug; 111(6):718-27. PubMed ID: 22798524
[TBL] [Abstract][Full Text] [Related]
16. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
Alp NJ; Mussa S; Khoo J; Cai S; Guzik T; Jefferson A; Goh N; Rockett KA; Channon KM
J Clin Invest; 2003 Sep; 112(5):725-35. PubMed ID: 12952921
[TBL] [Abstract][Full Text] [Related]
17. GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner.
Wang Z; Zhang N; Zhang M; Jiang Y; Ng AS; Bridges E; Zhang W; Zeng X; Luo Q; Liang J; Győrffy B; Hublitz P; Liang Z; Fischer R; Kerr D; Harris AL; Cai S
Cancer Res; 2023 Oct; 83(20):3400-3413. PubMed ID: 37463466
[TBL] [Abstract][Full Text] [Related]
18. Ionizing radiation induces BH
Yan T; Zhang T; Mu W; Qi Y; Guo S; Hu N; Zhao W; Zhang S; Wang Q; Shi L; Liu L
Biochem Pharmacol; 2020 Oct; 180():114102. PubMed ID: 32562786
[TBL] [Abstract][Full Text] [Related]
19. GCH1 attenuates cardiac autonomic nervous remodeling in canines with atrial-tachypacing via tetrahydrobiopterin pathway regulated by microRNA-206.
Wei J; Zhang Y; Li Z; Wang X; Chen L; Du J; Liu J; Liu J; Hou Y
Pacing Clin Electrophysiol; 2018 May; 41(5):459-471. PubMed ID: 29436714
[TBL] [Abstract][Full Text] [Related]
20. Combining Human and Rodent Genetics to Identify New Analgesics.
Latremoliere A; Costigan M
Neurosci Bull; 2018 Feb; 34(1):143-155. PubMed ID: 28667479
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
