178 related articles for article (PubMed ID: 38758800)
1. TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease.
Qin Y; Chen L; Zhu W; Song J; Lin J; Li Y; Zhang J; Song X; Xing T; Guo T; Duan X; Zhang Y; Ruan E; Wang Q; Li B; Yang W; Yin P; Yan XX; Li S; Li XJ; Yang S
Sci Adv; 2024 May; 10(20):eadl2036. PubMed ID: 38758800
[TBL] [Abstract][Full Text] [Related]
2. HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice.
Chen L; Qin Y; Guo T; Zhu W; Lin J; Xing T; Duan X; Zhang Y; Ruan E; Li X; Yin P; Li S; Li XJ; Yang S
Cell Death Dis; 2024 May; 15(5):337. PubMed ID: 38744826
[TBL] [Abstract][Full Text] [Related]
3. Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin.
Lin L; Jin Z; Tan H; Xu Q; Peng T; Li H
Brain Res; 2016 Jul; 1643():103-12. PubMed ID: 27107943
[TBL] [Abstract][Full Text] [Related]
4. Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.
Carbo M; Brandi V; Pascarella G; Staid DS; Colotti G; Polticelli F; Ilari A; Morea V
Int J Mol Med; 2019 Dec; 44(6):2223-2233. PubMed ID: 31638189
[TBL] [Abstract][Full Text] [Related]
5. Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease.
Louis Sam Titus ASC; Yusuff T; Cassar M; Thomas E; Kretzschmar D; D'Mello SR
J Neurosci; 2017 Jul; 37(27):6575-6587. PubMed ID: 28550168
[TBL] [Abstract][Full Text] [Related]
6. Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt
McAdam RL; Morton A; Gordon SL; Alterman JF; Khvorova A; Cousin MA; Smillie KJ
Neurobiol Dis; 2020 Feb; 134():104637. PubMed ID: 31614197
[TBL] [Abstract][Full Text] [Related]
7. Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
Zhang H; Li Q; Graham RK; Slow E; Hayden MR; Bezprozvanny I
Neurobiol Dis; 2008 Jul; 31(1):80-8. PubMed ID: 18502655
[TBL] [Abstract][Full Text] [Related]
8. Bim contributes to the progression of Huntington's disease-associated phenotypes.
Roberts SL; Evans T; Yang Y; Fu Y; Button RW; Sipthorpe RJ; Cowan K; Valionyte E; Anichtchik O; Li H; Lu B; Luo S
Hum Mol Genet; 2020 Jan; 29(2):216-227. PubMed ID: 31813995
[TBL] [Abstract][Full Text] [Related]
9. Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.
Wang N; Gray M; Lu XH; Cantle JP; Holley SM; Greiner E; Gu X; Shirasaki D; Cepeda C; Li Y; Dong H; Levine MS; Yang XW
Nat Med; 2014 May; 20(5):536-41. PubMed ID: 24784230
[TBL] [Abstract][Full Text] [Related]
10. Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Jiang M; Zhang X; Liu H; LeBron J; Alexandris A; Peng Q; Gu H; Yang F; Li Y; Wang R; Hou Z; Arbez N; Ren Q; Dong JL; Whela E; Wang R; Ratovitski T; Troncoso JC; Mori S; Ross CA; Lim J; Duan W
Hum Mol Genet; 2020 May; 29(8):1340-1352. PubMed ID: 32242231
[TBL] [Abstract][Full Text] [Related]
11. Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo Models.
Creus-Muncunill J; Ehrlich ME
Neurotherapeutics; 2019 Oct; 16(4):957-978. PubMed ID: 31529216
[TBL] [Abstract][Full Text] [Related]
12. Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.
Mende-Mueller LM; Toneff T; Hwang SR; Chesselet MF; Hook VY
J Neurosci; 2001 Mar; 21(6):1830-7. PubMed ID: 11245667
[TBL] [Abstract][Full Text] [Related]
13. Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice.
Petkau TL; Hill A; Connolly C; Lu G; Wagner P; Kosior N; Blanco J; Leavitt BR
Hum Mol Genet; 2019 May; 28(10):1661-1670. PubMed ID: 30624705
[TBL] [Abstract][Full Text] [Related]
14. Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.
Vodicka P; Chase K; Iuliano M; Valentine DT; Sapp E; Lu B; Kegel-Gleason KB; Sena-Esteves M; Aronin N; DiFiglia M
J Huntingtons Dis; 2016 Jun; 5(2):163-74. PubMed ID: 27314618
[TBL] [Abstract][Full Text] [Related]
15. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Hermel E; Gafni J; Propp SS; Leavitt BR; Wellington CL; Young JE; Hackam AS; Logvinova AV; Peel AL; Chen SF; Hook V; Singaraja R; Krajewski S; Goldsmith PC; Ellerby HM; Hayden MR; Bredesen DE; Ellerby LM
Cell Death Differ; 2004 Apr; 11(4):424-38. PubMed ID: 14713958
[TBL] [Abstract][Full Text] [Related]
16. IKKβ slows Huntington's disease progression in R6/1 mice.
Ochaba J; Fote G; Kachemov M; Thein S; Yeung SY; Lau AL; Hernandez S; Lim RG; Casale M; Neel MJ; Monuki ES; Reidling J; Housman DE; Thompson LM; Steffan JS
Proc Natl Acad Sci U S A; 2019 May; 116(22):10952-10961. PubMed ID: 31088970
[TBL] [Abstract][Full Text] [Related]
17. Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.
Dong X; Zong S; Witting A; Lindenberg KS; Kochanek S; Huang B
J Gene Med; 2012 Jul; 14(7):468-81. PubMed ID: 22700462
[TBL] [Abstract][Full Text] [Related]
18. Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.
Graham RK; Deng Y; Carroll J; Vaid K; Cowan C; Pouladi MA; Metzler M; Bissada N; Wang L; Faull RL; Gray M; Yang XW; Raymond LA; Hayden MR
J Neurosci; 2010 Nov; 30(45):15019-29. PubMed ID: 21068307
[TBL] [Abstract][Full Text] [Related]
19. Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease.
Caron NS; Southwell AL; Brouwers CC; Cengio LD; Xie Y; Black HF; Anderson LM; Ko S; Zhu X; van Deventer SJ; Evers MM; Konstantinova P; Hayden MR
Nucleic Acids Res; 2020 Jan; 48(1):36-54. PubMed ID: 31745548
[TBL] [Abstract][Full Text] [Related]
20. Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.
Lee CY; Cantle JP; Yang XW
FEBS J; 2013 Sep; 280(18):4382-94. PubMed ID: 23829302
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]