These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 38802343)

  • 1. Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform.
    Odorčić I; Hamed MB; Lismont S; Chávez-Gutiérrez L; Efremov RG
    Nat Commun; 2024 May; 15(1):4479. PubMed ID: 38802343
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.
    Zhou R; Yang G; Shi Y
    Proc Natl Acad Sci U S A; 2017 Nov; 114(48):12731-12736. PubMed ID: 29078389
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Toward the structure of presenilin/γ-secretase and presenilin homologs.
    Wolfe MS
    Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Membrane dynamics of γ-secretase with the anterior pharynx-defective 1B subunit.
    Dehury B; Kepp KP
    J Cell Biochem; 2021 Jan; 122(1):69-85. PubMed ID: 32830360
    [TBL] [Abstract][Full Text] [Related]  

  • 5. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
    Serneels L; Van Biervliet J; Craessaerts K; Dejaegere T; Horré K; Van Houtvin T; Esselmann H; Paul S; Schäfer MK; Berezovska O; Hyman BT; Sprangers B; Sciot R; Moons L; Jucker M; Yang Z; May PC; Karran E; Wiltfang J; D'Hooge R; De Strooper B
    Science; 2009 May; 324(5927):639-42. PubMed ID: 19299585
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators.
    Petit D; Hitzenberger M; Lismont S; Zoltowska KM; Ryan NS; Mercken M; Bischoff F; Zacharias M; Chávez-Gutiérrez L
    EMBO J; 2019 Jun; 38(12):. PubMed ID: 31109937
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.
    Chen AC; Guo LY; Ostaszewski BL; Selkoe DJ; LaVoie MJ
    J Biol Chem; 2010 Apr; 285(15):11378-91. PubMed ID: 20145246
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
    Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
    Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
    Liu L; Lauro BM; Wolfe MS; Selkoe DJ
    J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural Modeling of γ-Secretase Aβ
    Hitzenberger M; Zacharias M
    ACS Chem Neurosci; 2019 Mar; 10(3):1826-1840. PubMed ID: 30638370
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Membrane Dynamics of γ-Secretase Provides a Molecular Basis for β-Amyloid Binding and Processing.
    Somavarapu AK; Kepp KP
    ACS Chem Neurosci; 2017 Nov; 8(11):2424-2436. PubMed ID: 28841371
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
    Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
    Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.
    Szaruga M; Munteanu B; Lismont S; Veugelen S; Horré K; Mercken M; Saido TC; Ryan NS; De Vos T; Savvides SN; Gallardo R; Schymkowitz J; Rousseau F; Fox NC; Hopf C; De Strooper B; Chávez-Gutiérrez L
    Cell; 2017 Jul; 170(3):443-456.e14. PubMed ID: 28753424
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Macromolecular complex in recognition and proteolysis of amyloid precursor protein in Alzheimer's disease.
    Zhou R; Yang G; Shi Y
    Curr Opin Struct Biol; 2020 Apr; 61():1-8. PubMed ID: 31629221
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
    Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
    J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of distinct gamma-secretase complexes with different APH-1 variants.
    Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
    J Biol Chem; 2004 Oct; 279(40):41340-5. PubMed ID: 15286082
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular mechanism of substrate recognition and cleavage by human γ-secretase.
    Guo X; Li H; Yan C; Lei J; Zhou R; Shi Y
    Science; 2024 Jun; 384(6700):1091-1095. PubMed ID: 38843321
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.
    Fernandez MA; Klutkowski JA; Freret T; Wolfe MS
    J Biol Chem; 2014 Nov; 289(45):31043-52. PubMed ID: 25239621
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.