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22. Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model. Miki K; Xu M; An Z; Wang X; Yang M; Al-Refaie W; Sun X; Baranov E; Tan Y; Chishima T; Shimada H; Moossa AR; Hoffman RM Cancer Gene Ther; 2000 Feb; 7(2):332-8. PubMed ID: 10770644 [TBL] [Abstract][Full Text] [Related]
23. Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis. Machover D; Zittoun J; Saffroy R; Broët P; Giraudier S; Magnaldo T; Goldschmidt E; Debuire B; Orrico M; Tan Y; Mishal Z; Chevallier O; Tonetti C; Jouault H; Ulusakarya A; Tanguy ML; Metzger G; Hoffman RM Cancer Res; 2002 Aug; 62(16):4685-9. PubMed ID: 12183426 [TBL] [Abstract][Full Text] [Related]
24. Cytotoxic synergism of methioninase in combination with 5-fluorouracil and folinic acid. Machover D; Zittoun J; Broët P; Metzger G; Orrico M; Goldschmidt E; Schilf A; Tonetti C; Tan Y; Delmas-Marsalet B; Luccioni C; Falissard B; Hoffman RM Biochem Pharmacol; 2001 Apr; 61(7):867-76. PubMed ID: 11274973 [TBL] [Abstract][Full Text] [Related]
25. Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice. Tan Y; Sun X; Xu M; Tan X; Sasson A; Rashidi B; Han Q; Tan X; Wang X; An Z; Sun FX; Hoffman RM Clin Cancer Res; 1999 Aug; 5(8):2157-63. PubMed ID: 10473100 [TBL] [Abstract][Full Text] [Related]
26. Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Sugisawa N; Higuchi T; Han Q; Hozumi C; Yamamoto J; Tashiro Y; Nishino H; Kawaguchi K; Bouvet M; Murata T; Unno M; Hoffman RM Cancer Chemother Pharmacol; 2021 Jul; 88(1):61-67. PubMed ID: 33768300 [TBL] [Abstract][Full Text] [Related]
27. Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer. Kawaguchi K; Miyake K; Han Q; Li S; Tan Y; Igarashi K; Lwin TM; Higuchi T; Kiyuna T; Miyake M; Oshiro H; Bouvet M; Unno M; Hoffman RM Cell Cycle; 2018; 17(7):868-873. PubMed ID: 29623758 [TBL] [Abstract][Full Text] [Related]
28. Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model. Higuchi T; Han Q; Miyake K; Oshiro H; Sugisawa N; Tan Y; Yamamoto N; Hayashi K; Kimura H; Miwa S; Igarashi K; Bouvet M; Singh SR; Tsuchiya H; Hoffman RM Biochem Biophys Res Commun; 2020 Feb; 523(1):135-139. PubMed ID: 31839218 [TBL] [Abstract][Full Text] [Related]
29. Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma. Igarashi K; Kawaguchi K; Kiyuna T; Miyake K; Miyaki M; Yamamoto N; Hayashi K; Kimura H; Miwa S; Higuchi T; Singh AS; Chmielowski B; Nelson SD; Russell TA; Eckardt MA; Dry SM; Li Y; Singh SR; Chawla SP; Eilber FC; Tsuchiya H; Hoffman RM Biochem Biophys Res Commun; 2018 Dec; 506(4):912-917. PubMed ID: 30392912 [TBL] [Abstract][Full Text] [Related]
30. Recombinant Methioninase as a DNA Demethylation Agent. Hoffman RM; Machover D Methods Mol Biol; 2019; 1866():279-284. PubMed ID: 30725424 [TBL] [Abstract][Full Text] [Related]
31. Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro. Hoda MA; Pirker C; Dong Y; Schelch K; Heffeter P; Kryeziu K; van Schoonhoven S; Klikovits T; Laszlo V; Rozsas A; Ozsvar J; Klepetko W; Döme B; Grusch M; Hegedüs B; Berger W Mol Cancer Ther; 2016 Oct; 15(10):2357-2369. PubMed ID: 27512118 [TBL] [Abstract][Full Text] [Related]
32. Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth? Hoffman RM; Han Q; Kawaguchi K; Li S; Tan Y Methods Mol Biol; 2019; 1866():311-322. PubMed ID: 30725426 [TBL] [Abstract][Full Text] [Related]
33. Expression of PD-L1 Is Increased by Methionine Restriction Using Recombinant Methioninase in Human Colorectal Cancer Cells. Mizuta K; Kang BM; Han Q; Kubota Y; Morinaga S; Sato M; Bouvet M; Tome Y; Nishida K; Hoffman RM Cancer Genomics Proteomics; 2024; 21(4):395-398. PubMed ID: 38944421 [TBL] [Abstract][Full Text] [Related]
34. Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model. Aoki Y; Tome Y; Han Q; Yamamoto J; Hamada K; Masaki N; Kubota Y; Bouvet M; Nishida K; Hoffman RM Anticancer Res; 2022 Feb; 42(2):731-737. PubMed ID: 35093871 [TBL] [Abstract][Full Text] [Related]
35. Synergy of Rapamycin and Methioninase on Colorectal Cancer Cells Requires Simultaneous and Not Sequential Administration: Implications for mTOR Inhibition. Ardjmand D; Sato M; Han Q; Kubota Y; Mizuta K; Morinaga S; Hoffman RM Cancer Diagn Progn; 2024; 4(4):396-401. PubMed ID: 38962555 [TBL] [Abstract][Full Text] [Related]
37. Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention. Kawaguchi K; Han Q; Li S; Tan Y; Igarashi K; Kiyuna T; Miyake K; Miyake M; Chmielowski B; Nelson SD; Russell TA; Dry SM; Li Y; Singh AS; Eckardt MA; Unno M; Eilber FC; Hoffman RM Cell Cycle; 2018; 17(3):356-361. PubMed ID: 29187018 [TBL] [Abstract][Full Text] [Related]
38. Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro. Tan Y; Xu M; Hoffman RM Anticancer Res; 2010 Mar; 30(3):793-8. PubMed ID: 20392998 [TBL] [Abstract][Full Text] [Related]