These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy. Moore AS; Holzbaur EL Proc Natl Acad Sci U S A; 2016 Jun; 113(24):E3349-58. PubMed ID: 27247382 [TBL] [Abstract][Full Text] [Related]
5. The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy. Heo JM; Ordureau A; Paulo JA; Rinehart J; Harper JW Mol Cell; 2015 Oct; 60(1):7-20. PubMed ID: 26365381 [TBL] [Abstract][Full Text] [Related]
6. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Lazarou M; Sliter DA; Kane LA; Sarraf SA; Wang C; Burman JL; Sideris DP; Fogel AI; Youle RJ Nature; 2015 Aug; 524(7565):309-314. PubMed ID: 26266977 [TBL] [Abstract][Full Text] [Related]
7. Optineurin provides a mitophagy contact site for TBK1 activation. Yamano K; Sawada M; Kikuchi R; Nagataki K; Kojima W; Endo R; Kinefuchi H; Sugihara A; Fujino T; Watanabe A; Tanaka K; Hayashi G; Murakami H; Matsuda N EMBO J; 2024 Mar; 43(5):754-779. PubMed ID: 38287189 [TBL] [Abstract][Full Text] [Related]
8. LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy. Padman BS; Nguyen TN; Uoselis L; Skulsuppaisarn M; Nguyen LK; Lazarou M Nat Commun; 2019 Jan; 10(1):408. PubMed ID: 30679426 [TBL] [Abstract][Full Text] [Related]
9. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Richter B; Sliter DA; Herhaus L; Stolz A; Wang C; Beli P; Zaffagnini G; Wild P; Martens S; Wagner SA; Youle RJ; Dikic I Proc Natl Acad Sci U S A; 2016 Apr; 113(15):4039-44. PubMed ID: 27035970 [TBL] [Abstract][Full Text] [Related]
10. Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner. Zhang C; Nie P; Zhou C; Hu Y; Duan S; Gu M; Jiang D; Wang Y; Deng Z; Chen J; Chen S; Wang L Cell Death Dis; 2021 Feb; 12(2):209. PubMed ID: 33627622 [TBL] [Abstract][Full Text] [Related]
11. Wauters F; Cornelissen T; Imberechts D; Martin S; Koentjoro B; Sue C; Vangheluwe P; Vandenberghe W Autophagy; 2020 Feb; 16(2):203-222. PubMed ID: 30945962 [TBL] [Abstract][Full Text] [Related]
12. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Araya J; Tsubouchi K; Sato N; Ito S; Minagawa S; Hara H; Hosaka Y; Ichikawa A; Saito N; Kadota T; Yoshida M; Fujita Y; Utsumi H; Kobayashi K; Yanagisawa H; Hashimoto M; Wakui H; Ishikawa T; Numata T; Kaneko Y; Asano H; Yamashita M; Odaka M; Morikawa T; Nishimura SL; Nakayama K; Kuwano K Autophagy; 2019 Mar; 15(3):510-526. PubMed ID: 30290714 [TBL] [Abstract][Full Text] [Related]
13. PINK1-mediated mitophagy maintains pluripotency through optineurin. Wang C; Liu K; Cao J; Wang L; Zhao Q; Li Z; Zhang H; Chen Q; Zhao T Cell Prolif; 2021 May; 54(5):e13034. PubMed ID: 33931895 [TBL] [Abstract][Full Text] [Related]
14. Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy. Yamano K; Youle RJ Autophagy; 2020 Nov; 16(11):2105-2107. PubMed ID: 32892694 [TBL] [Abstract][Full Text] [Related]
15. TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery. Saha B; Olsvik H; Williams GL; Oh S; Evjen G; Sjøttem E; Mandell MA Cell Rep; 2024 Jun; 43(6):114294. PubMed ID: 38814780 [TBL] [Abstract][Full Text] [Related]
16. Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. Wong YC; Holzbaur EL Proc Natl Acad Sci U S A; 2014 Oct; 111(42):E4439-48. PubMed ID: 25294927 [TBL] [Abstract][Full Text] [Related]