BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 38919958)

  • 1. Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease.
    van Dijk MJ; Ruiter TJJ; van der Veen S; Rab MAE; van Oirschot BA; Bos J; Derichs C; Rijneveld AW; Cnossen MH; Nur E; Biemond BJ; Bartels M; Schutgens REG; van Solinge WW; Jans JJM; van Beers EJ; van Wijk R
    Hemasphere; 2024 Jun; 8(6):e109. PubMed ID: 38919958
    [TBL] [Abstract][Full Text] [Related]  

  • 2. One-year safety and efficacy of mitapivat in sickle cell disease: follow-up results of a phase 2, open-label study.
    van Dijk MJ; Rab MAE; van Oirschot BA; Bos J; Derichs C; Rijneveld AW; Cnossen MH; Nur E; Biemond BJ; Bartels M; Jans JJM; van Solinge WW; Schutgens REG; van Wijk R; van Beers EJ
    Blood Adv; 2023 Dec; 7(24):7539-7550. PubMed ID: 37934880
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease.
    Schroeder P; Fulzele K; Forsyth S; Ribadeneira MD; Guichard S; Wilker E; Marshall CG; Drake A; Fessler R; Konstantinidis DG; Seu KG; Kalfa TA
    J Pharmacol Exp Ther; 2022 Mar; 380(3):210-219. PubMed ID: 35031585
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.
    D'Alessandro A; Le K; Lundt M; Li Q; Dunkelberger EB; Cellmer T; Worth AJ; Patil S; Huston C; Grier A; Dzieciatkowska M; Stephenson D; Eaton WA; Thein SL
    Haematologica; 2024 Mar; ():. PubMed ID: 38450513
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mitapivat for sickle cell disease and thalassemia.
    Pilo F; Angelucci E
    Drugs Today (Barc); 2023 Mar; 59(3):125-134. PubMed ID: 36847623
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyruvate kinase activators: targeting red cell metabolism in sickle cell disease.
    Xu JZ; Vercellotti GM
    Hematology Am Soc Hematol Educ Program; 2023 Dec; 2023(1):107-113. PubMed ID: 38066891
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.
    Quezado ZMN; Kamimura S; Smith M; Wang X; Heaven MR; Jana S; Vogel S; Zerfas P; Combs CA; Almeida LEF; Li Q; Quezado M; Horkayne-Szakaly I; Kosinski PA; Yu S; Kapadnis U; Kung C; Dang L; Wakim P; Eaton WA; Alayash AI; Thein SL
    Blood Cells Mol Dis; 2022 Jul; 95():102660. PubMed ID: 35366607
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease.
    Xu JZ; Conrey A; Frey I; Gwaabe E; Menapace LA; Tumburu L; Lundt M; Lequang T; Li Q; Glass K; Dunkelberger EB; Iyer V; Mangus H; Kung C; Dang L; Kosinski PA; Hawkins P; Jeffries N; Eaton WA; Lay Thein S
    Blood; 2022 Nov; 140(19):2053-2062. PubMed ID: 35576529
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mitapivat: A Review in Pyruvate Kinase Deficiency in Adults.
    Zhuang-Yan A; Shirley M
    Drugs; 2023 Nov; 83(17):1613-1620. PubMed ID: 37991635
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mitapivat: A Quinolone Sulfonamide to Manage Hemolytic Anemia in Adults With Pyruvate Kinase Deficiency.
    Wills J; Horenstein M; Kim A; Silva MA; Dima L
    Am J Ther; 2023 Sep-Oct 01; 30(5):e433-e438. PubMed ID: 37713687
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mitapivat in adult patients with pyruvate kinase deficiency receiving regular transfusions (ACTIVATE-T): a multicentre, open-label, single-arm, phase 3 trial.
    Glenthøj A; van Beers EJ; Al-Samkari H; Viprakasit V; Kuo KHM; Galactéros F; Chonat S; Porter J; Zagadailov E; Xu R; Oluyadi A; Hawkins P; Gheuens S; Beynon V; Barcellini W;
    Lancet Haematol; 2022 Oct; 9(10):e724-e732. PubMed ID: 35988546
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mitapivat, a novel pyruvate kinase activator, for the treatment of hereditary hemolytic anemias.
    Al-Samkari H; van Beers EJ
    Ther Adv Hematol; 2021; 12():20406207211066070. PubMed ID: 34987744
    [TBL] [Abstract][Full Text] [Related]  

  • 13. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.
    Rab MAE; Van Oirschot BA; Kosinski PA; Hixon J; Johnson K; Chubukov V; Dang L; Pasterkamp G; Van Straaten S; Van Solinge WW; Van Beers EJ; Kung C; Van Wijk R
    Haematologica; 2021 Jan; 106(1):238-249. PubMed ID: 31974203
    [TBL] [Abstract][Full Text] [Related]  

  • 14.
    D'Alessandro A; Nouraie SM; Zhang Y; Cendali F; Gamboni F; Reisz JA; Zhang X; Bartsch KW; Galbraith MD; Gordeuk VR; Gladwin MT
    bioRxiv; 2023 Feb; ():. PubMed ID: 36824724
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An innovative phase I study in healthy subjects to determine the mass balance, elimination, metabolism, and absolute bioavailability of mitapivat.
    Prakash C; Mangus H; Yan Y; Yang H; Iyer V
    Clin Transl Sci; 2023 Oct; 16(10):2021-2032. PubMed ID: 37596712
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mitapivat versus Placebo for Pyruvate Kinase Deficiency.
    Al-Samkari H; Galactéros F; Glenthøj A; Rothman JA; Andres O; Grace RF; Morado-Arias M; Layton DM; Onodera K; Verhovsek M; Barcellini W; Chonat S; Judge MP; Zagadailov E; Xu R; Hawkins P; Beynon V; Gheuens S; van Beers EJ;
    N Engl J Med; 2022 Apr; 386(15):1432-1442. PubMed ID: 35417638
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Erythrocyte pyruvate kinase activation in red cell disorders.
    Matte A; Federti E; De Franceschi L
    Curr Opin Hematol; 2023 May; 30(3):93-98. PubMed ID: 36853806
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mitapivat improves ineffective erythropoiesis and iron overload in adult patients with pyruvate kinase deficiency.
    van Beers EJ; Al-Samkari H; Grace RF; Barcellini W; Glenthøj A; DiBacco M; Wind-Rotolo M; Xu R; Beynon V; Patel P; Porter JB; Kuo KHM
    Blood Adv; 2024 May; 8(10):2433-2441. PubMed ID: 38330179
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mitapivat: A Novel Treatment of Hemolytic Anemia in Adults with Pyruvate Kinase Deficiency.
    De SK
    Curr Med Chem; 2024; 31(6):683-687. PubMed ID: 37125655
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction.
    D'Alessandro A; Nouraie SM; Zhang Y; Cendali F; Gamboni F; Reisz JA; Zhang X; Bartsch KW; Galbraith MD; Gordeuk VR; Gladwin MT
    Am J Hematol; 2023 Jul; 98(7):1017-1028. PubMed ID: 36971592
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.