These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 39025847)

  • 1. WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis.
    Rodríguez Pérez F; Natwick D; Schiff L; McSwiggen D; Heckert A; Huey M; Morrison H; Loo M; Miranda RG; Filbin J; Ortega J; Van Buren K; Murnock D; Tao A; Butler R; Cheng K; Tarvestad W; Zhang Z; Gonzalez E; Miller RM; Kelly M; Tang Y; Ho J; Anderson D; Bashore C; Basham S
    Nat Commun; 2024 Jul; 15(1):6059. PubMed ID: 39025847
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
    Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
    Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability.
    Tejwani V; Carroll T; Macartney T; Bandau S; Alabert C; Saredi G; Toth R; Rouse J
    Sci Rep; 2024 Sep; 14(1):20824. PubMed ID: 39242638
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells.
    Picco G; Rao Y; Al Saedi A; Lee Y; Vieira SF; Bhosle S; May K; Herranz-Ors C; Walker SJ; Shenje R; Dincer C; Gibson F; Banerjee R; Hewitson Z; Werner T; Cottom JE; Peng Y; Deng N; Zhang Y; Nartey EN; Nickels L; Landis P; Conticelli D; McCarten K; Bush J; Sharma M; Lightfoot H; House D; Milford E; Grant EK; Glogowski MP; Wagner CD; Bantscheff M; Rutkowska-Klute A; ; Zappacosta F; Pettinger J; Barthorpe S; Eberl HC; Jones BT; Schneck JL; Murphy DJ; Voest EE; Taygerly JP; DeMartino MP; Coelho MA; Houseley J; Sharma G; Schwartz B; Garnett MJ
    Cancer Discov; 2024 Aug; 14(8):1457-1475. PubMed ID: 38587317
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
    Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
    Elife; 2019 Mar; 8():. PubMed ID: 30910006
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
    Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
    Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
    Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T
    Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
    Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A
    Genes Dev; 2023 Oct; 37(19-20):913-928. PubMed ID: 37932011
    [TBL] [Abstract][Full Text] [Related]  

  • 9. WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.
    Datta A; Biswas K; Sommers JA; Thompson H; Awate S; Nicolae CM; Thakar T; Moldovan GL; Shoemaker RH; Sharan SK; Brosh RM
    Nat Commun; 2021 Nov; 12(1):6561. PubMed ID: 34772932
    [TBL] [Abstract][Full Text] [Related]  

  • 10. WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
    Mengoli V; Ceppi I; Sanchez A; Cannavo E; Halder S; Scaglione S; Gaillard PH; McHugh PJ; Riesen N; Pettazzoni P; Cejka P
    EMBO J; 2023 Feb; 42(3):e111998. PubMed ID: 36541070
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
    Krastev DB; Li S; Sun Y; Wicks AJ; Hoslett G; Weekes D; Badder LM; Knight EG; Marlow R; Pardo MC; Yu L; Talele TT; Bartek J; Choudhary JS; Pommier Y; Pettitt SJ; Tutt ANJ; Ramadan K; Lord CJ
    Nat Cell Biol; 2022 Jan; 24(1):62-73. PubMed ID: 35013556
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
    Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
    Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
    Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
    Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
    [TBL] [Abstract][Full Text] [Related]  

  • 14. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
    Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
    Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
    Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA
    Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936
    [TBL] [Abstract][Full Text] [Related]  

  • 16. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
    Chan EM; Foster KJ; Bass AJ
    Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
    [TBL] [Abstract][Full Text] [Related]  

  • 17. DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP.
    Partridge JJ; Lopreiato JO; Latterich M; Indig FE
    Mol Biol Cell; 2003 Oct; 14(10):4221-9. PubMed ID: 12937274
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Challenges for the Discovery of Non-Covalent WRN Helicase Inhibitors.
    Heuser A; Abdul Rahman W; Bechter E; Blank J; Buhr S; Erdmann D; Fontana P; Mermet-Meillon F; Meyerhofer M; Strang R; Schrapp M; Zimmermann C; Cortes-Cros M; Möbitz H; Hamon J
    ChemMedChem; 2024 Apr; 19(8):e202300613. PubMed ID: 38334957
    [TBL] [Abstract][Full Text] [Related]  

  • 19. WRN Helicase: Is There More to MSI-H than Immunotherapy?
    Wainberg ZA
    Cancer Discov; 2024 Aug; 14(8):1369-1371. PubMed ID: 39091203
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin.
    He J; Zhu Q; Wani G; Sharma N; Wani AA
    J Biol Chem; 2016 Apr; 291(14):7396-408. PubMed ID: 26826127
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.