234 related articles for article (PubMed ID: 3924048)
1. Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis.
Bitonti AJ; Bacchi CJ; McCann PP; Sjoerdsma A
Biochem Pharmacol; 1985 May; 34(10):1773-7. PubMed ID: 3924048
[TBL] [Abstract][Full Text] [Related]
2. Polyamine metabolism: a potential therapeutic target in trypanosomes.
Bacchi CJ; Nathan HC; Hutner SH; McCann PP; Sjoerdsma A
Science; 1980 Oct; 210(4467):332-4. PubMed ID: 6775372
[TBL] [Abstract][Full Text] [Related]
3. In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.
Bacchi CJ; Garofalo J; Mockenhaupt D; McCann PP; Diekema KA; Pegg AE; Nathan HC; Mullaney EA; Chunosoff L; Sjoerdsma A; Hutner SH
Mol Biochem Parasitol; 1983 Mar; 7(3):209-25. PubMed ID: 6193423
[TBL] [Abstract][Full Text] [Related]
4. Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models.
Bacchi CJ; Nathan HC; Clarkson AB; Bienen EJ; Bitonti AJ; McCann PP; Sjoerdsma A
Am J Trop Med Hyg; 1987 Jan; 36(1):46-52. PubMed ID: 3101528
[TBL] [Abstract][Full Text] [Related]
5. Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine.
Byers TL; Bush TL; McCann PP; Bitonti AJ
Biochem J; 1991 Mar; 274 ( Pt 2)(Pt 2):527-33. PubMed ID: 1672500
[TBL] [Abstract][Full Text] [Related]
6. Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections.
Nathan HC; Bacchi CJ; Hutner SH; Rescigno D; McCann PP; Sjoerdsma A
Biochem Pharmacol; 1981 Nov; 30(21):3010-3. PubMed ID: 6797437
[No Abstract] [Full Text] [Related]
7. Ornithine decarboxylase in Trypanosoma brucei brucei: evidence for selective toxicity of difluoromethylornithine.
Garofalo J; Bacchi CJ; McLaughlin SD; Mockenhaupt D; Trueba G; Hutner SH
J Protozool; 1982 Aug; 29(3):389-94. PubMed ID: 6813460
[TBL] [Abstract][Full Text] [Related]
8. Further studies on difluoromethylornithine in African trypanosomes.
McCann PP; Bacchi CJ; Clarkson AB; Seed JR; Nathan HC; Amole BO; Hutner SH; Sjoerdsma A
Med Biol; 1981 Dec; 59(5-6):434-40. PubMed ID: 6175860
[TBL] [Abstract][Full Text] [Related]
9. Trypanocidal activity of tetradentated pyridine-based manganese complexes is not linked to inactivation of superoxide dismutase.
Steverding D; Kolosevska K; Sánchez-Moreno M
Exp Parasitol; 2018 Sep; 192():1-5. PubMed ID: 30026114
[TBL] [Abstract][Full Text] [Related]
10. Effect of putrescine on the respiration of Trypanosoma brucei brucei.
Giffin BF; McCann PP; Bacchi CJ
Mol Biochem Parasitol; 1986 Aug; 20(2):165-71. PubMed ID: 3092047
[TBL] [Abstract][Full Text] [Related]
11. Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase.
Smithson DC; Lee J; Shelat AA; Phillips MA; Guy RK
J Biol Chem; 2010 May; 285(22):16771-81. PubMed ID: 20220141
[TBL] [Abstract][Full Text] [Related]
12. Polyamine depletion following exposure to DL-alpha-difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei.
Giffin BF; McCann PP; Bitonti AJ; Bacchi CJ
J Protozool; 1986 May; 33(2):238-43. PubMed ID: 3090240
[TBL] [Abstract][Full Text] [Related]
13. Mathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identification.
Gu X; Reid D; Higham DJ; Gilbert D
PLoS One; 2013; 8(1):e53734. PubMed ID: 23372667
[TBL] [Abstract][Full Text] [Related]
14. Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.
Sjoerdsma A; Golden JA; Schechter PJ; Barlow JL; Santi DV
Trans Assoc Am Physicians; 1984; 97():70-9. PubMed ID: 6442954
[No Abstract] [Full Text] [Related]
15. Evaluation of DL-alpha-difluoromethylornithine against susceptible and drug-resistant Trypanosoma brucei brucei.
Zweygarth E; Kaminsky R
Acta Trop; 1991 Jan; 48(3):223-32. PubMed ID: 1671624
[TBL] [Abstract][Full Text] [Related]
16. Morphological changes in Trypanosoma brucei rhodesiense following inhibition of polyamine biosynthesis in vivo.
de Gee AL; Carstens PH; McCann PP; Mansfield JM
Tissue Cell; 1984; 16(5):731-8. PubMed ID: 6440309
[TBL] [Abstract][Full Text] [Related]
17. In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.
Bacchi CJ; Brun R; Croft SL; Alicea K; Bühler Y
Antimicrob Agents Chemother; 1996 Jun; 40(6):1448-53. PubMed ID: 8726018
[TBL] [Abstract][Full Text] [Related]
18. Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial.
Van Nieuwenhove S; Schechter PJ; Declercq J; Boné G; Burke J; Sjoerdsma A
Trans R Soc Trop Med Hyg; 1985; 79(5):692-8. PubMed ID: 3938090
[TBL] [Abstract][Full Text] [Related]
19. Mode of interaction of ornithine decarboxylase with antizyme and alpha-difluoromethylornithine.
Kyriakidis DA; Flamigni F; Pawlak JW; Canellakis ES
Biochem Pharmacol; 1984 May; 33(9):1575-8. PubMed ID: 6428422
[No Abstract] [Full Text] [Related]
20. [DFMO: an alternative therapeutic agent for human African trypanosomiasis].
Breton JC; Bouteille B; Sonan T
Bull Soc Pathol Exot Filiales; 1988; 81(3 Pt 2):571-7. PubMed ID: 3143490
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
