These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

97 related articles for article (PubMed ID: 3973903)

  • 1. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives.
    Stokker GE; Hoffman WF; Alberts AW; Cragoe EJ; Deana AA; Gilfillan JL; Huff JW; Novello FC; Prugh JD; Smith RL
    J Med Chem; 1985 Mar; 28(3):347-58. PubMed ID: 3973903
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.
    Hoffman WF; Alberts AW; Cragoe EJ; Deana AA; Evans BE; Gilfillan JL; Gould NP; Huff JW; Novello FC; Prugh JD
    J Med Chem; 1986 Feb; 29(2):159-69. PubMed ID: 3950901
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.
    Stokker GE; Alberts AW; Anderson PS; Cragoe EJ; Deana AA; Gilfillan JL; Hirshfield J; Holtz WJ; Hoffman WF; Huff JW
    J Med Chem; 1986 Feb; 29(2):170-81. PubMed ID: 3950902
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of arylnaphthalenyl derivatives: inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme a reductase.
    Mewshaw RE; Hild EK; Commons TJ; Strike DP
    Drug Des Deliv; 1988 Nov; 3(3):235-43. PubMed ID: 3255330
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidenyl)-3,5-dihydroxyhexanoic acids and their lactone derivatives.
    Stokker GE; Alberts AW; Gilfillan JL; Huff JW; Smith RL
    J Med Chem; 1986 May; 29(5):852-5. PubMed ID: 3701793
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro.
    Ishigami M; Honda T; Takasaki W; Ikeda T; Komai T; Ito K; Sugiyama Y
    Drug Metab Dispos; 2001 Mar; 29(3):282-8. PubMed ID: 11181496
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (beta-lactones).
    Romo D; Harrison PH; Jenkins SI; Riddoch RW; Park K; Yang HW; Zhao C; Wright GD
    Bioorg Med Chem; 1998 Aug; 6(8):1255-72. PubMed ID: 9784867
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mode of interaction of beta-hydroxy-beta-methylglutaryl coenzyme A reductase with strong binding inhibitors: compactin and related compounds.
    Nakamura CE; Abeles RH
    Biochemistry; 1985 Mar; 24(6):1364-76. PubMed ID: 3886005
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 6. Trans-6-[2-(substituted-1-naphthyl)ethyl(or ethenyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones.
    Prugh JD; Alberts AW; Deana AA; Gilfillian JL; Huff JW; Smith RL; Wiggins JM
    J Med Chem; 1990 Feb; 33(2):758-65. PubMed ID: 2299642
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 2-oxetanones with a side chain mimicking the extended structure of 1233A.
    Hashizume H; Ito H; Morikawa T; Kanaya N; Nagashima H; Usui H; Tomoda H; Sunazuka T; Kumagai H; Omura S
    Chem Pharm Bull (Tokyo); 1994 Oct; 42(10):2097-107. PubMed ID: 7805135
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase inhibitors: 2-oxetanones with a side chain mimicking the folded structure of 1233A.
    Hashizume H; Ito H; Yamada K; Nagashima H; Kanao M; Tomoda H; Sunazuka T; Kumagai H; Omura S
    Chem Pharm Bull (Tokyo); 1994 Mar; 42(3):512-20. PubMed ID: 7911741
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis of 2,4-dideoxy-D-erythro-hexopyranose. An intermediate for synthesis of the lactone moiety of inhibitors of hydroxymethylglutaryl-coenzyme A reductase.
    Ho PT; Chung S
    Carbohydr Res; 1984 Feb; 125(2):318-22. PubMed ID: 6704999
    [No Abstract]   [Full Text] [Related]  

  • 13. Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.
    Jendralla H; Granzer E; von Kerekjarto B; Krause R; Schacht U; Baader E; Bartmann W; Beck G; Bergmann A; Kesseler K
    J Med Chem; 1991 Oct; 34(10):2962-83. PubMed ID: 1656041
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis of 7-(2,4-dichlorophenyl)-D-erythro-3-hydroxy-5-heptanolide, 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexane-1-sulfonic acid, and 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexylphosphonic acid.
    Hodosi G; Galambos G; Podányi B; Kuszmann J
    Carbohydr Res; 1992 Mar; 225(2):269-78. PubMed ID: 1643652
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.
    Beck G; Kesseler K; Baader E; Bartmann W; Bergmann A; Granzer E; Jendralla H; von Kerekjarto B; Krause R; Paulus E
    J Med Chem; 1990 Jan; 33(1):52-60. PubMed ID: 2296036
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.
    Greenspan MD; Yudkovitz JB; Lo CY; Chen JS; Alberts AW; Hunt VM; Chang MN; Yang SS; Thompson KL; Chiang YC
    Proc Natl Acad Sci U S A; 1987 Nov; 84(21):7488-92. PubMed ID: 2890166
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition.
    Aboushadi N; Shackelford JE; Jessani N; Gentile A; Krisans SK
    Biochemistry; 2000 Jan; 39(1):237-47. PubMed ID: 10625499
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Study on the conversion of three natural statins from lactone forms to their corresponding hydroxy acid forms and their determination in Pu-Erh tea.
    Yang DJ; Hwang LS
    J Chromatogr A; 2006 Jun; 1119(1-2):277-84. PubMed ID: 16388814
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Differential inhibition of HMG-CoA synthase and pancreatic lipase by the specific chiral isomers of beta-lactone DU-6622.
    Tomoda H; Ohbayashi N; Kumagai H; Hashizume H; Sunazuka T; Omura S
    Biochem Biophys Res Commun; 1999 Nov; 265(2):536-40. PubMed ID: 10558904
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Isopentenoid synthesis in eukaryotic cells. An initiating role for post-translational control of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
    Giron MD; Havel CM; Watson JA
    Arch Biochem Biophys; 1993 Apr; 302(1):265-71. PubMed ID: 8097083
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.