BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

230 related articles for article (PubMed ID: 4016793)

  • 1. High-performance liquid chromatographic and enzyme-inhibition assays of methotrexate concentrations in serum from patients receiving high-dose therapy: tight binding of some methotrexate to a protein that could be dihydrofolate reductase.
    Iven H; Bartels H
    Cancer Treat Rep; 1985; 69(7-8):825-32. PubMed ID: 4016793
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.
    Jolivet J; Chabner BA
    J Clin Invest; 1983 Sep; 72(3):773-8. PubMed ID: 6193143
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Methotrexate and 7-hydroxymethotrexate: serum level monitoring by high-performance liquid chromatography.
    Canfell C; Sadée W
    Cancer Treat Rep; 1980 Jan; 64(1):165-9. PubMed ID: 7379052
    [TBL] [Abstract][Full Text] [Related]  

  • 4. High-presssure liquid chromatographic determination of methotrexate and its major metabolite, 7-hydroxymethotrexate, in human plasma.
    Watson E; Cohen JL; Chan KK
    Cancer Treat Rep; 1978 Mar; 62(3):381-7. PubMed ID: 647697
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A simple radiometric assay for methotrexate and other folate antagonists.
    Hayman RJ; Fong H; Van der Weyden MB
    J Lab Clin Med; 1979 Mar; 93(3):480-4. PubMed ID: 311801
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A direct ligand-binding radioassay for the measurement of methotrexate in tissues and biological fluids.
    Arons E; Rothenberg SP; Costa MD; Fischer C; Iqbal MP
    Cancer Res; 1975 Aug; 35(8):2033-8. PubMed ID: 807320
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G; Wright JE; Rosowsky A
    Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
    [TBL] [Abstract][Full Text] [Related]  

  • 8. [Serum monitoring of methotrexate (MTX) and 7-hydroxymethotrexate concentrations in patients treated with MTX using high-pressure liquid chromatography (HPLC) and comparison of serum MTX levels between HPLC method and fluorescence polarization immunoassay (FPIA)].
    Sakamoto S; Matsuhisa T; Miyoshi K; Naruse R; Urayama H; Shimokawa T; Okabe K; Toki H; Motoi M; Moriwaki S
    Gan To Kagaku Ryoho; 1991 Jun; 18(7):1119-25. PubMed ID: 2053771
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular mechanisms of resistance to antifolates, a review.
    Banerjee D; Ercikan-Abali E; Waltham M; Schnieders B; Hochhauser D; Li WW; Fan J; Gorlick R; Goker E; Bertino JR
    Acta Biochim Pol; 1995; 42(4):457-64. PubMed ID: 8852336
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays.
    Fotoohi K; Skärby T; Söderhäll S; Peterson C; Albertioni F
    J Chromatogr B Analyt Technol Biomed Life Sci; 2005 Mar; 817(2):139-44. PubMed ID: 15686977
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Increasing methotrexate resistance by combination of active-site mutations in human dihydrofolate reductase.
    Volpato JP; Fossati E; Pelletier JN
    J Mol Biol; 2007 Oct; 373(3):599-611. PubMed ID: 17868689
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Formation of 7-hydroxymethotrexate polyglutamyl derivatives and their cytotoxicity in human chronic myelogenous leukemia cells, in vitro.
    Fabre G; Goldman ID
    Cancer Res; 1985 Jan; 45(1):80-5. PubMed ID: 2578101
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The use of protein as a carrier of methotrexate for experimental cancer chemotherapy. III. Human serum albumin-methotrexate derivative, its preparation and basic testing.
    Bures L; Bostík J; Motycka K; Spundová M; Rehák L
    Neoplasma; 1988; 35(3):329-42. PubMed ID: 3405341
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Establishment of dihydrofolate reductase-increased human cell lines and relationship between dihydrofolate reductase levels and gene copy.
    Domin BA; Grill SP; Cheng Y
    Cancer Res; 1983 May; 43(5):2155-8. PubMed ID: 6831441
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Monitoring the administration of methotrexate in antimetabolite therapy.
    Epstein E; Baginski ES; Zac B
    Ann Clin Lab Sci; 1976; 6(4):312-7. PubMed ID: 9024
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Methotrexate and its drug resistance].
    Nagura E
    Gan To Kagaku Ryoho; 1988 Oct; 15(10):2882-7. PubMed ID: 3178237
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Transgenic mice expressing the tyr22 variant of murine DHFR: protection of transgenic marrow transplant recipients from lethal doses of methotrexate.
    James RI; May C; Vagt MD; Studebaker R; McIvor RS
    Exp Hematol; 1997 Nov; 25(12):1286-95. PubMed ID: 9357973
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vivo methotrexate kinetics and metabolism in human hematopoietic cells. Clinical significance of methotrexate concentrations in erythrocytes.
    Schrøder H
    Dan Med Bull; 1990 Feb; 37(1):22-40. PubMed ID: 2178886
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activity of free and carrier-bound methotrexate against transport-deficient and high dihydrofolate dehydrogenase-containing methotrexate-resistant L1210 cells.
    Chu BC; Fan CC; Howell SB
    J Natl Cancer Inst; 1981 Jan; 66(1):121-4. PubMed ID: 6935452
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Methotrexate dose-escalation studies in transgenic mice and marrow transplant recipients expressing drug-resistant dihydrofolate reductase activity.
    May C; James RI; Gunther R; McIvor RS
    J Pharmacol Exp Ther; 1996 Sep; 278(3):1444-51. PubMed ID: 8819532
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.