These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 4045922)

  • 1. Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.
    Jones TR; Calvert AH; Jackman AL; Eakin MA; Smithers MJ; Betteridge RF; Newell DR; Hayter AJ; Stocker A; Harland SJ
    J Med Chem; 1985 Oct; 28(10):1468-76. PubMed ID: 4045922
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position.
    Marsham PR; Chambers P; Hayter AJ; Hughes LR; Jackman AL; O'Connor BM; Bishop JA; Calvert AH
    J Med Chem; 1989 Mar; 32(3):569-75. PubMed ID: 2918503
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.
    Thornton TJ; Jones TR; Jackman AL; Flinn A; O'Connor BM; Warner P; Calvert AH
    J Med Chem; 1991 Mar; 34(3):978-84. PubMed ID: 2002476
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent.
    Jones TR; Betteridge RF; Neidle S; Jackman AL; Calvert AH
    Anticancer Drug Des; 1989 Mar; 3(4):243-8. PubMed ID: 2930626
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Quinazoline antifolates inhibiting thymidylate synthase: variation of the amino acid.
    Jones TR; Smithers MJ; Betteridge RF; Taylor MA; Jackman AL; Calvert AH; Davies LC; Harrap KR
    J Med Chem; 1986 Jun; 29(6):1114-8. PubMed ID: 3712376
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
    Jackman AL; Marsham PR; Thornton TJ; Bishop JA; O'Connor BM; Hughes LR; Calvert AH; Jones TR
    J Med Chem; 1990 Nov; 33(11):3067-71. PubMed ID: 2231607
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications.
    Jones TR; Smithers MJ; Taylor MA; Jackman AL; Calvert AH; Harland SJ; Harrap KR
    J Med Chem; 1986 Apr; 29(4):468-72. PubMed ID: 3754284
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.
    Thornton TJ; Jackman AL; Marsham PR; O'Connor BM; Bishop JA; Calvert AH
    J Med Chem; 1992 Jun; 35(12):2321-7. PubMed ID: 1613755
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.
    Jones TR; Thornton TJ; Flinn A; Jackman AL; Newell DR; Calvert AH
    J Med Chem; 1989 Apr; 32(4):847-52. PubMed ID: 2704030
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.
    Hughes LR; Jackman AL; Oldfield J; Smith RC; Burrows KD; Marsham PR; Bishop JA; Jones TR; O'Connor BM; Calvert AH
    J Med Chem; 1990 Nov; 33(11):3060-7. PubMed ID: 2231606
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.
    Marsham PR; Jackman AL; Oldfield J; Hughes LR; Thornton TJ; Bisset GM; O'Connor BM; Bishop JA; Calvert AH
    J Med Chem; 1990 Nov; 33(11):3072-8. PubMed ID: 2231608
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.
    McNamara DJ; Berman EM; Fry DW; Werbel LM
    J Med Chem; 1990 Jul; 33(7):2045-51. PubMed ID: 2362285
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.
    Warner P; Barker AJ; Jackman AL; Burrows KD; Roberts N; Bishop JA; O'Connor BM; Hughes LR
    J Med Chem; 1992 Jul; 35(15):2761-8. PubMed ID: 1495009
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
    Nair MG; Nanavati NT; Nair IG; Kisliuk RL; Gaumont Y; Hsiao MC; Kalman TI
    J Med Chem; 1986 Sep; 29(9):1754-60. PubMed ID: 3091832
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Quinazoline antifolates inhibiting thymidylate synthase: synthesis of four oligo(L-gamma-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid and their enzyme inhibition.
    Pawelczak K; Jones TR; Kempny M; Jackman AL; Newell DR; Krzyzanowski L; Rzeszotarska B
    J Med Chem; 1989 Jan; 32(1):160-5. PubMed ID: 2909728
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Bavetsias V; Jackman AL; Kimbell R; Gibson W; Boyle FT; Bisset GM
    J Med Chem; 1996 Jan; 39(1):73-85. PubMed ID: 8568829
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
    Jackman AL; Alison DL; Calvert AH; Harrap KR
    Cancer Res; 1986 Jun; 46(6):2810-5. PubMed ID: 2938731
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid.
    Nair MG; Salter DC; Kisliuk RL; Gaumont Y; North G; Sirotnak FM
    J Med Chem; 1983 Apr; 26(4):605-7. PubMed ID: 6403710
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A; Galivan J; Beardsley GP; Bader H; O'Connor BM; Russello O; Moroson BA; DeYarman MT; Kerwar SS; Freisheim JH
    Cancer Res; 1992 Apr; 52(8):2148-55. PubMed ID: 1313737
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
    Marsham PR; Jackman AL; Barker AJ; Boyle FT; Pegg SJ; Wardleworth JM; Kimbell R; O'Connor BM; Calvert AH; Hughes LR
    J Med Chem; 1995 Mar; 38(6):994-1004. PubMed ID: 7699716
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.