BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 4066708)

  • 1. Specific chemical modifications in the beta-cleft site of hemoglobin. Potential anti-sickling agents with hybrid functionalities.
    Klotz IM; Haney DN; Wood LE
    J Biol Chem; 1985 Dec; 260(30):16215-23. PubMed ID: 4066708
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.
    Xu GG; Pagare PP; Ghatge MS; Safo RP; Gazi A; Chen Q; David T; Alabbas AB; Musayev FN; Venitz J; Zhang Y; Safo MK; Abdulmalik O
    Mol Pharm; 2017 Oct; 14(10):3499-3511. PubMed ID: 28858508
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.
    Pagare PP; Ghatge MS; Musayev FN; Deshpande TM; Chen Q; Braxton C; Kim S; Venitz J; Zhang Y; Abdulmalik O; Safo MK
    Bioorg Med Chem; 2018 May; 26(9):2530-2538. PubMed ID: 29655608
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural specificities in acylation of hemoglobin and sickle hemoglobin by diaspirins.
    Wood LE; Haney DN; Patel JR; Clare SE; Shi GY; King LC; Klotz IM
    J Biol Chem; 1981 Jul; 256(13):7046-52. PubMed ID: 7240262
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural features required for the reactivity and intracellular transport of bis(3,5-dibromosalicyl)fumarate and related anti-sickling compounds that modify hemoglobin S at the 2,3-diphosphoglycerate binding site.
    Chatterjee R; Iwai Y; Walder RY; Walder JA
    J Biol Chem; 1984 Dec; 259(23):14863-73. PubMed ID: 6501320
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.
    Safo MK; Abdulmalik O; Danso-Danquah R; Burnett JC; Nokuri S; Joshi GS; Musayev FN; Asakura T; Abraham DJ
    J Med Chem; 2004 Sep; 47(19):4665-76. PubMed ID: 15341482
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents.
    Omar AM; Mahran MA; Ghatge MS; Chowdhury N; Bamane FH; El-Araby ME; Abdulmalik O; Safo MK
    Org Biomol Chem; 2015 Jun; 13(22):6353-70. PubMed ID: 25974708
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular basis for the anti-sickling activity of aromatic amino acids and related compounds: a proton nuclear magnetic resonance investigation.
    Russu IM; Lin AK; Yang CP; Ho C
    Biochemistry; 1986 Feb; 25(4):808-15. PubMed ID: 3964645
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Physiological and x-ray studies of potential antisickling agents.
    Abraham DJ; Perutz MF; Phillips SE
    Proc Natl Acad Sci U S A; 1983 Jan; 80(2):324-8. PubMed ID: 6572894
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeted modification of furan-2-carboxaldehydes into Michael acceptor analogs yielded long-acting hemoglobin modulators with dual antisickling activities.
    Omar AM; Abdulmalik O; El-Say KM; Ghatge MS; Cyril-Olutayo M; Paredes S; Al-Awadh M; El-Araby ME; Safo MK
    Chem Biol Drug Des; 2024 Jan; 103(1):e14371. PubMed ID: 37798397
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation.
    Deshpande TM; Pagare PP; Ghatge MS; Chen Q; Musayev FN; Venitz J; Zhang Y; Abdulmalik O; Safo MK
    Acta Crystallogr D Struct Biol; 2018 Oct; 74(Pt 10):956-964. PubMed ID: 30289405
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin.
    Abdulmalik O; Ghatge MS; Musayev FN; Parikh A; Chen Q; Yang J; Nnamani I; Danso-Danquah R; Eseonu DN; Asakura T; Abraham DJ; Venitz J; Safo MK
    Acta Crystallogr D Biol Crystallogr; 2011 Nov; 67(Pt 11):920-8. PubMed ID: 22101818
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Chemical modification of human hemoglobin by antisickling concentrations of nitrogen mustard.
    Roth EF; Arnone A; Bookchin RM; Nagel RL
    Blood; 1981 Aug; 58(2):300-8. PubMed ID: 7248523
    [No Abstract]   [Full Text] [Related]  

  • 14. Design, synthesis, and testing of potential antisickling agents. 9. Cyclic tetrapeptide homologs as mimics of the mutation site of hemoglobin S.
    Sheh L; Mokotoff M; Abraham DJ
    Int J Pept Protein Res; 1987 Apr; 29(4):509-20. PubMed ID: 3596902
    [TBL] [Abstract][Full Text] [Related]  

  • 15. New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?
    Oder E; Safo MK; Abdulmalik O; Kato GJ
    Br J Haematol; 2016 Oct; 175(1):24-30. PubMed ID: 27605087
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and testing of potential antisickling agents. 10. (2,2-Dimethylchroman-6-yl)alkanoic acids.
    Fatope MO; Abraham DJ
    J Med Chem; 1987 Nov; 30(11):1973-7. PubMed ID: 3669005
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effect of cetiedil on erythrocyte sickling: new type of antisickling agent that may affect erythrocyte membranes.
    Asakura T; Ohnishi ST; Adachi K; Ozguc M; Hashimoto K; Singer M; Russell MO; Schwartz E
    Proc Natl Acad Sci U S A; 1980 May; 77(5):2955-9. PubMed ID: 6930678
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Thermodynamics of anti-sickling agents with hemoglobin S.
    Benedict RC; Richey B; Fall L; Gill SJ; Nagel RL; Wyman J
    J Mol Biol; 1981 Aug; 150(3):423-34. PubMed ID: 7299823
    [No Abstract]   [Full Text] [Related]  

  • 19. The mechanism of action of two anti-sickling agents: sodium cyanate and glyceraldehyde.
    Manning JM; Acharya AS
    Am J Pediatr Hematol Oncol; 1984; 6(1):51-4. PubMed ID: 6711764
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin.
    Omar AM; Mahran MA; Ghatge MS; Bamane FH; Ahmed MH; El-Araby ME; Abdulmalik O; Safo MK
    Molecules; 2016 Aug; 21(8):. PubMed ID: 27529207
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.