150 related articles for article (PubMed ID: 4546895)
1. Quinazoline antifolates as inhibitors of growth, dihydrofolate reductase, and thymidylate synthetase of mouse neuroblastoma cells in culture.
Carlin SC; Rosenberg RN; VandeVenter L; Friedkin M
Mol Pharmacol; 1974 Mar; 10(2):194-203. PubMed ID: 4546895
[No Abstract] [Full Text] [Related]
2. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists.
Chello PL; McQueen CA; DeAngelis LM; Bertino JR
Cancer Res; 1976 Jul; 36(7 PT 1):2442-9. PubMed ID: 1277151
[TBL] [Abstract][Full Text] [Related]
3. Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma.
Baskin F; Carlin SC; Kraus P; Friedkin M; Rosenberg RN
Mol Pharmacol; 1975 Jan; 11(1):105-17. PubMed ID: 123312
[No Abstract] [Full Text] [Related]
4. Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics.
Jackman AL; Calvert AH; Hart LI; Harrap KR
Adv Exp Med Biol; 1984; 165 Pt B():375-8. PubMed ID: 6720434
[No Abstract] [Full Text] [Related]
5. Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
van der Wilt CL; Backus HH; Smid K; Comijn L; Veerman G; Wouters D; Voorn DA; Priest DG; Bunni MA; Mitchell F; Jackman AL; Jansen G; Peters GJ
Cancer Res; 2001 May; 61(9):3675-81. PubMed ID: 11325838
[TBL] [Abstract][Full Text] [Related]
6. Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-(( 2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-L-glutamic acid (CB3717), on human lymphoblastoid cells.
Jackson RC; Jackman AL; Calvert AH
Biochem Pharmacol; 1983 Dec; 32(24):3783-90. PubMed ID: 6661252
[TBL] [Abstract][Full Text] [Related]
7. Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition.
Seither RL; Trent DF; Mikulecky DC; Rape TJ; Goldman ID
J Biol Chem; 1991 Mar; 266(7):4112-8. PubMed ID: 1825652
[TBL] [Abstract][Full Text] [Related]
8. Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
Fernandes DJ; Bertino JR; Hynes JB
Cancer Res; 1983 Mar; 43(3):1117-23. PubMed ID: 6825083
[No Abstract] [Full Text] [Related]
9. Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.
Hennequin LF; Boyle FT; Wardleworth JM; Marsham PR; Kimbell R; Jackman AL
J Med Chem; 1996 Feb; 39(3):695-704. PubMed ID: 8576912
[TBL] [Abstract][Full Text] [Related]
10. 3D-QSAR studies on quinazoline antifolate thymidylate synthase inhibitors by CoMFA and CoMSIA models.
Srivastava V; Gupta SP; Siddiqi MI; Mishra BN
Eur J Med Chem; 2010 Apr; 45(4):1560-71. PubMed ID: 20153089
[TBL] [Abstract][Full Text] [Related]
11. Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent.
Jones TR; Betteridge RF; Neidle S; Jackman AL; Calvert AH
Anticancer Drug Des; 1989 Mar; 3(4):243-8. PubMed ID: 2930626
[TBL] [Abstract][Full Text] [Related]
12. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
Westerhof GR; Schornagel JH; Kathmann I; Jackman AL; Rosowsky A; Forsch RA; Hynes JB; Boyle FT; Peters GJ; Pinedo HM
Mol Pharmacol; 1995 Sep; 48(3):459-71. PubMed ID: 7565626
[TBL] [Abstract][Full Text] [Related]
13. A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice.
Jones TR; Calvert AH; Jackman AL; Brown SJ; Jones M; Harrap KR
Eur J Cancer (1965); 1981 Jan; 17(1):11-9. PubMed ID: 7262141
[No Abstract] [Full Text] [Related]
14. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA
J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414
[TBL] [Abstract][Full Text] [Related]
15. Multivariate analysis and quantitative structure-activity relationships. Inhibition of dihydrofolate reductase and thymidylate synthetase by quinazolines.
Chen BK; Horváth C; Bertino JR
J Med Chem; 1979 May; 22(5):483-91. PubMed ID: 110930
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of thymidylate synthetase of the human lymphocytes.
Haurani FI
Cancer Biochem Biophys; 1979; 4(2):75-7. PubMed ID: 317899
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of thymidylate synthetase and dihydrofolate reductase by naturally occurring oligoglutamate derivatives of folic acid.
Friedkin M; Plante LT; Crawford EJ; Crumm M
J Biol Chem; 1975 Jul; 250(14):5614-21. PubMed ID: 1095583
[TBL] [Abstract][Full Text] [Related]
18. Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Bavetsias V; Jackman AL; Kimbell R; Gibson W; Boyle FT; Bisset GM
J Med Chem; 1996 Jan; 39(1):73-85. PubMed ID: 8568829
[TBL] [Abstract][Full Text] [Related]
19. Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717.
Jackman AL; Taylor GA; Calvert AH; Harrap KR
Biochem Pharmacol; 1984 Oct; 33(20):3269-75. PubMed ID: 6487375
[TBL] [Abstract][Full Text] [Related]
20. Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.
Jackman AL; Kimbell R; Brown M; Brunton L; Boyle FT
Anticancer Drug Des; 1995 Oct; 10(7):555-72. PubMed ID: 7495479
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
