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4. Effects on dihydrofolate reductase of methotrexate metabolites and intracellular folates formed following methotrexate exposure of human breast cancer cells. Drake JC; Allegra CJ; Baram J; Kaufman BT; Chabner BA Biochem Pharmacol; 1987 Jul; 36(14):2416-8. PubMed ID: 2440441 [No Abstract] [Full Text] [Related]
5. The inhibition of dihydrofolate reductase by folate analogues: structural requirements for slow- and tight-binding inhibition. Williams JW; Duggleby RG; Cutler R; Morrison JF Biochem Pharmacol; 1980 Feb; 29(4):589-95. PubMed ID: 7370052 [No Abstract] [Full Text] [Related]
6. Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase. Sirotnak FM Biochim Biophys Acta; 1973 Mar; 302(1):13-23. PubMed ID: 4144236 [No Abstract] [Full Text] [Related]
7. Number of binding sites and possible mechanisms of action. Condit PT Ann N Y Acad Sci; 1971 Nov; 186():363-4. PubMed ID: 4943807 [No Abstract] [Full Text] [Related]
8. Mutations of human dihydrofolate reductase causing decreased inhibition by methotrexate. Blakley RL; Appleman JR; Chunduru SK; Nakano T; Lewis WS; Harris SE Adv Exp Med Biol; 1993; 338():473-9. PubMed ID: 8304162 [No Abstract] [Full Text] [Related]
9. Role of the cellular oxidation-reduction state in methotrexate binding to dihydrofolate reductase and dissociation induced by reduced folates. Matherly LH; Anderson LA; Goldman ID Cancer Res; 1984 Jun; 44(6):2325-30. PubMed ID: 6609765 [TBL] [Abstract][Full Text] [Related]
11. Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase. Huang Z; Wagner CR; Benkovic SJ Biochemistry; 1994 Sep; 33(38):11576-85. PubMed ID: 7918371 [TBL] [Abstract][Full Text] [Related]
12. Competitive dihydrofolate reductase binding assay of triazinate (NSC-139105), methasquin (NSC-122870), and aminopterin (NSC739). Myers CE; Eliot HM; Chabner BA Cancer Treat Rep; 1976 May; 60(5):615-6. PubMed ID: 1033031 [No Abstract] [Full Text] [Related]
13. Nobel lecture in physiology or medicine--1988. Selective inhibitors of dihydrofolate reductase. Hitchings GH In Vitro Cell Dev Biol; 1989 Apr; 25(4):303-10. PubMed ID: 2654121 [No Abstract] [Full Text] [Related]
14. Dihydrofolate reductase: binding of substrates and inhibitors and catalytic mechanism. Gready JE Adv Pharmacol Chemother; 1980; 17():37-102. PubMed ID: 7004143 [No Abstract] [Full Text] [Related]
15. Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies. Subramanian S; Kaufman BT Proc Natl Acad Sci U S A; 1978 Jul; 75(7):3201-5. PubMed ID: 28523 [TBL] [Abstract][Full Text] [Related]
16. Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate. Matthews DA; Alden RA; Bolin JT; Freer ST; Hamlin R; Xuong N; Kraut J; Poe M; Williams M; Hoogsteen K Science; 1977 Jul; 197(4302):452-5. PubMed ID: 17920 [TBL] [Abstract][Full Text] [Related]
17. Toxicity of methotrexate and metoprine in a dihydrofolate reductase gene-amplified mouse cell line. Hamrell M; Laszlo J; Brown OE; Sedwick WD Mol Pharmacol; 1981 Nov; 20(3):637-43. PubMed ID: 7329406 [No Abstract] [Full Text] [Related]
18. The binding of substrates and inhibitors to dihydrofolate reductase. Roberts GC Biochem Soc Trans; 1975; 3(5):630-1. PubMed ID: 261 [No Abstract] [Full Text] [Related]
19. Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells. Matherly LH; Barlowe CK; Goldman ID Cancer Res; 1986 Feb; 46(2):588-93. PubMed ID: 2416428 [TBL] [Abstract][Full Text] [Related]
20. Identification of dihydrofolate reductase in rabbit brain. Spector R; Levy P; Abelson HT Biochem Pharmacol; 1977 Aug; 26(16):1507-11. PubMed ID: 901568 [No Abstract] [Full Text] [Related] [Next] [New Search]