These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Inhibitor binding analysis of dihydrofolate reductases from various species. Burchall JJ; Hitchings GH Mol Pharmacol; 1965 Sep; 1(2):126-36. PubMed ID: 4378654 [No Abstract] [Full Text] [Related]
3. Role of inhibitors in studies of comparative enzymology. Hitchings GH Fed Proc; 1967; 26(4):1078-81. PubMed ID: 6028773 [No Abstract] [Full Text] [Related]
4. Species differences among dihydrofolate reductases as a basis for chemotherapy. Hitchings GH Postgrad Med J; 1969 Nov; 45():Suppl:7-10. PubMed ID: 5361314 [No Abstract] [Full Text] [Related]
6. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS. Rosowsky A; Forsch RA; Queener SF J Med Chem; 2003 Apr; 46(9):1726-36. PubMed ID: 12699390 [TBL] [Abstract][Full Text] [Related]
7. 2,4-diamino-5-(3,5-dimethoxy-4-substituted)-benzyl-pyrimidines as ligands in affinity chromatography of bacterial dihydrofolate reductases. Then RL Biochim Biophys Acta; 1980 Jul; 614(1):25-30. PubMed ID: 7397201 [TBL] [Abstract][Full Text] [Related]
8. The gel-filtration behaviour of dihydrofolate reductases from culture forms of trypanosomatids. Gutteridge WE; Jaffe JJ; McCormack JJ Biochim Biophys Acta; 1969; 191(3):753-5. PubMed ID: 5363996 [No Abstract] [Full Text] [Related]
9. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Cody V; Luft JR; Pangborn W Acta Crystallogr D Biol Crystallogr; 2005 Feb; 61(Pt 2):147-55. PubMed ID: 15681865 [TBL] [Abstract][Full Text] [Related]
10. Cooperativity in ligand binding to dihydrofolate reductase. Birdsall B; Burgen AS; Rodrigues de Miranda J; Roberts GC Biochemistry; 1978 May; 17(11):2102-10. PubMed ID: 307400 [No Abstract] [Full Text] [Related]
11. Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases. Gangjee A; Elzein E; Queener SF; McGuire JJ J Med Chem; 1998 Apr; 41(9):1409-16. PubMed ID: 9554874 [TBL] [Abstract][Full Text] [Related]
12. Specific protection of folate reductase against chemical and proteolytic inactivation. Hakala MT; Suolinna EM Mol Pharmacol; 1966 Sep; 2(5):465-80. PubMed ID: 6008166 [No Abstract] [Full Text] [Related]
13. Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate. Pineda P; Kanter A; McIvor RS; Benkovic SJ; Rosowsky A; Wagner CR J Med Chem; 2003 Jul; 46(14):2816-8. PubMed ID: 12825924 [TBL] [Abstract][Full Text] [Related]
14. Role of the cellular oxidation-reduction state in methotrexate binding to dihydrofolate reductase and dissociation induced by reduced folates. Matherly LH; Anderson LA; Goldman ID Cancer Res; 1984 Jun; 44(6):2325-30. PubMed ID: 6609765 [TBL] [Abstract][Full Text] [Related]
15. Models for the binding of methotrexate to Escherichia coli dihydrofolate reductase: direct effect of carboxylate of aspartic acid 27 upon ultraviolet spectrum of methotrexate. Schlegel HB; Poe M; Hoogsteen K Mol Pharmacol; 1981 Jul; 20(1):154-8. PubMed ID: 7027022 [No Abstract] [Full Text] [Related]
16. Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. Gangjee A; Mavandadi F; Queener SF J Med Chem; 1997 Mar; 40(7):1173-7. PubMed ID: 9089339 [TBL] [Abstract][Full Text] [Related]
18. Trimethoprim and brodimoprim resistance of gram-positive and gram-negative bacteria. Thomson CJ J Chemother; 1993 Dec; 5(6):458-64. PubMed ID: 8195838 [TBL] [Abstract][Full Text] [Related]
19. Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate reductase by 5-formyltetrahydrofolate in Ehrlich ascites tumor cells in vitro. Matherly LH; Fry DW; Goldman ID Cancer Res; 1983 Jun; 43(6):2694-9. PubMed ID: 6189586 [TBL] [Abstract][Full Text] [Related]
20. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate. Senkovich O; Schormann N; Chattopadhyay D Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]