These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

386 related articles for article (PubMed ID: 599411)

  • 1. Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.
    Pang KS; Rowland M
    J Pharmacokinet Biopharm; 1977 Dec; 5(6):625-53. PubMed ID: 599411
    [No Abstract]   [Full Text] [Related]  

  • 2. A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity.
    Roberts MS; Rowland M
    J Pharmacokinet Biopharm; 1986 Jun; 14(3):261-88. PubMed ID: 3783447
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Models of hepatic drug clearance: discrimination between the 'well stirred' and 'parallel-tube' models.
    Ahmad AB; Bennett PN; Rowland M
    J Pharm Pharmacol; 1983 Apr; 35(4):219-24. PubMed ID: 6133930
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Altered hepatic blood flow and drug disposition.
    Nies AS; Shand DG; Wilkinson GR
    Clin Pharmacokinet; 1976; 1(2):135-55. PubMed ID: 13954
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Commentary: a physiological approach to hepatic drug clearance.
    Wilkinson GR; Shand DG
    Clin Pharmacol Ther; 1975 Oct; 18(4):377-90. PubMed ID: 1164821
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model.
    Hsu SH; Cheng AC; Chang TY; Pao LH; Hsiong CH; Wang HJ
    Biomed Pharmacother; 2021 Sep; 141():111855. PubMed ID: 34229248
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hepatic drug clearance model: comparison among the distributed, parallel-tube and well-stirred models.
    Sawada Y; Sugiyama Y; Miyamoto Y; Iga T; Hanano M
    Chem Pharm Bull (Tokyo); 1985 Jan; 33(1):319-26. PubMed ID: 4006023
    [No Abstract]   [Full Text] [Related]  

  • 8. Misuse of the well-stirred model of hepatic drug clearance.
    Yang J; Jamei M; Yeo KR; Rostami-Hodjegan A; Tucker GT
    Drug Metab Dispos; 2007 Mar; 35(3):501-2. PubMed ID: 17325025
    [No Abstract]   [Full Text] [Related]  

  • 9. Impact of input parameters on the prediction of hepatic plasma clearance using the well-stirred model.
    Wan H; Bold P; Larsson LO; Ulander J; Peters S; Löfberg B; Ungell AL; Någård M; Llinàs A
    Curr Drug Metab; 2010 Sep; 11(7):583-94. PubMed ID: 20629632
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data.
    Dong J; Park MS
    Eur J Pharm Sci; 2018 Nov; 124():46-60. PubMed ID: 30102979
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hepatic elimination of drugs with concentration-dependent serum protein binding.
    Huang JD; Oie S
    J Pharmacokinet Biopharm; 1984 Feb; 12(1):67-81. PubMed ID: 6747819
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Influence of plasma protein binding kinetics on hepatic clearance assessed from a "tube" model and a "well-stirred" model.
    Jansen JA
    J Pharmacokinet Biopharm; 1981 Feb; 9(1):15-26. PubMed ID: 7229915
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hepatic clearance measurements and pharmacokinetics.
    Keiding S; Andreasen PB
    Pharmacology; 1979; 19(3):105-10. PubMed ID: 392549
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A new model-independent physiological approach to study hepatic drug clearance and its applications.
    Chiou WL
    Int J Clin Pharmacol Ther Toxicol; 1984 Nov; 22(11):577-90. PubMed ID: 6389376
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Membrane transport in hepatic clearance of drugs. I: Extended hepatic clearance models incorporating concentration-dependent transport and elimination processes.
    Kwon Y; Morris ME
    Pharm Res; 1997 Jun; 14(6):774-9. PubMed ID: 9210196
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Determination of hepatic clearance with the account of drug-protein binding kinetics.
    Berezhkovskiy LM
    J Pharm Sci; 2012 Oct; 101(10):3936-45. PubMed ID: 22767378
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Hepatic clearance of drugs. Physiological and pharmacokinetic considerations].
    Pellegrin P; Lesne M
    J Pharmacol; 1983; 14(2):107-39. PubMed ID: 6865443
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality?
    Pang KS; Han YR; Noh K; Lee PI; Rowland M
    Biochem Pharmacol; 2019 Nov; 169():113596. PubMed ID: 31398312
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes.
    Ito K; Houston JB
    Pharm Res; 2004 May; 21(5):785-92. PubMed ID: 15180335
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Clearance and biologic half-life as indices of intrinsic hepatic metabolism.
    Perrier D; Gibaldi M
    J Pharmacol Exp Ther; 1974 Oct; 191(1):17-24. PubMed ID: 4423599
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 20.