These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 6130925)

  • 1. Metabolism of phencyclidine. The role of iminium ion formation in covalent binding to rabbit microsomal protein.
    Ward DP; Trevor AJ; Kalir A; Adams JD; Baillie TA; Castagnoli N
    Drug Metab Dispos; 1982; 10(6):690-5. PubMed ID: 6130925
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phencyclidine iminium ion. NADPH-dependent metabolism, covalent binding to macromolecules, and inactivation of cytochrome(s) P-450.
    Hoag MK; Trevor AJ; Kalir A; Castagnoli N
    Drug Metab Dispos; 1987; 15(4):485-90. PubMed ID: 2888621
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolism-dependent inactivation of liver microsomal enzymes by phencyclidine.
    Hoag MK; Trevor AJ; Asscher Y; Weissman J; Castagnoli N
    Drug Metab Dispos; 1984; 12(3):371-5. PubMed ID: 6145566
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
    Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolism-dependent covalent binding of (S)-[5-3H]nicotine to liver and lung microsomal macromolecules.
    Shigenaga MK; Trevor AJ; Castagnoli N
    Drug Metab Dispos; 1988; 16(3):397-402. PubMed ID: 2900731
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rates of phencyclidine metabolism by the isolated perfused lung, lung microsomes, and liver microsomes of rabbits.
    Law FC
    Drug Metab Dispos; 1982; 10(4):361-5. PubMed ID: 6126335
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Selective mechanism-based inactivation of the major phenobarbital-inducible P-450 cytochrome from rabbit liver by phencyclidine and its oxidation product, the iminium compound.
    Osawa Y; Coon MJ
    Drug Metab Dispos; 1989; 17(1):7-13. PubMed ID: 2566474
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The microsomal metabolism and site of covalent binding to protein of 3'-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen.
    Streeter AJ; Bjorge SM; Axworthy DB; Nelson SD; Baillie TA
    Drug Metab Dispos; 1984; 12(5):565-76. PubMed ID: 6149906
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mechanism-based inactivation of rat liver cytochrome P4502B1 by phencyclidine and its oxidative product, the iminium ion.
    Crowley JR; Hollenberg PF
    Drug Metab Dispos; 1995 Aug; 23(8):786-93. PubMed ID: 7493543
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of novel phencyclidine metabolites formed in vitro by rabbit microsomal metabolism.
    Herber R; Perrin R; Ziegler JM; Villoutreix J; Minn A; Siest G
    Xenobiotica; 1991 Nov; 21(11):1493-9. PubMed ID: 1763523
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cyanide trapping of iminium ion reactive intermediates followed by detection and structure identification using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
    Argoti D; Liang L; Conteh A; Chen L; Bershas D; Yu CP; Vouros P; Yang E
    Chem Res Toxicol; 2005 Oct; 18(10):1537-44. PubMed ID: 16533017
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Selective pathways for the metabolism of phencyclidine by cytochrome p450 2b enzymes: identification of electrophilic metabolites, glutathione, and N-acetyl cysteine adducts.
    Shebley M; Jushchyshyn MI; Hollenberg PF
    Drug Metab Dispos; 2006 Mar; 34(3):375-83. PubMed ID: 16326815
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolism of the cytochrome P450 mechanism-based inhibitor N-benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: comparative study with 1-aminobenzotriazole.
    Woodcroft KJ; Webb CD; Yao M; Weedon AC; Bend JR
    Chem Res Toxicol; 1997 May; 10(5):589-99. PubMed ID: 9168258
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity.
    Zhao Z; Koeplinger KA; Padbury GE; Hauer MJ; Bundy GL; Banitt LS; Schwartz TM; Zimmermann DC; Harbach PR; Mayo JK; Aaron CS
    Chem Res Toxicol; 1996 Dec; 9(8):1230-9. PubMed ID: 8951224
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanism of covalent adduct formation of diclofenac to rat hepatic microsomal proteins. Retention of the glucuronic acid moiety in the adduct.
    Kretz-Rommel A; Boelsterli UA
    Drug Metab Dispos; 1994; 22(6):956-61. PubMed ID: 7895615
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
    Munns AJ; De Voss JJ; Hooper WD; Dickinson RG; Gillam EM
    Chem Res Toxicol; 1997 Sep; 10(9):1049-58. PubMed ID: 9305589
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of the NADPH-dependent covalent binding of [14C]halothane to human liver microsomes: a role for cytochrome P4502E1 at low substrate concentrations.
    Madan A; Parkinson A
    Drug Metab Dispos; 1996 Dec; 24(12):1307-13. PubMed ID: 8971135
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of cyanide-trapped methylated metabonates formed during reactive drug metabolite screening in vitro.
    Rousu T; Tolonen A
    Rapid Commun Mass Spectrom; 2011 May; 25(10):1382-90. PubMed ID: 21504003
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Metabolism of phencyclidine by human liver microsomes.
    Laurenzana EM; Owens SM
    Drug Metab Dispos; 1997 May; 25(5):557-63. PubMed ID: 9152594
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.
    Sahali-Sahly Y; Balani SK; Lin JH; Baillie TA
    Chem Res Toxicol; 1996 Sep; 9(6):1007-12. PubMed ID: 8870989
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.