362 related articles for article (PubMed ID: 6173112)
1. In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
Spears CP; Shahinian AH; Moran RG; Heidelberger C; Corbett TH
Cancer Res; 1982 Feb; 42(2):450-6. PubMed ID: 6173112
[TBL] [Abstract][Full Text] [Related]
2. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.
Spears CP; Gustavsson BG; Berne M; Frösing R; Bernstein L; Hayes AA
Cancer Res; 1988 Oct; 48(20):5894-900. PubMed ID: 3167844
[TBL] [Abstract][Full Text] [Related]
3. Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.
Spears CP; Gustavsson BG; Mitchell MS; Spicer D; Berne M; Bernstein L; Danenberg PV
Cancer Res; 1984 Sep; 44(9):4144-50. PubMed ID: 6744325
[TBL] [Abstract][Full Text] [Related]
4. Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
van Laar JA; van der Wilt CL; Rustum YM; Noordhuis P; Smid K; Pinedo HM; Peters GJ
Clin Cancer Res; 1996 Aug; 2(8):1327-33. PubMed ID: 9816304
[TBL] [Abstract][Full Text] [Related]
5. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
[TBL] [Abstract][Full Text] [Related]
6. Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil.
Berger SH; Hakala MT
Mol Pharmacol; 1984 Mar; 25(2):303-9. PubMed ID: 6608049
[TBL] [Abstract][Full Text] [Related]
7. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.
Aschele C; Sobrero A; Faderan MA; Bertino JR
Cancer Res; 1992 Apr; 52(7):1855-64. PubMed ID: 1532346
[TBL] [Abstract][Full Text] [Related]
8. Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.
Houghton JA; Maroda SJ; Phillips JO; Houghton PJ
Cancer Res; 1981 Jan; 41(1):144-9. PubMed ID: 7448754
[TBL] [Abstract][Full Text] [Related]
9. Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
Ren Q; Van Groeningen CJ; Hardcastle A; Aherne GW; Geoffroy F; Allegra CJ; Johnston PG; Grem JL
Oncol Res; 1997; 9(2):77-88. PubMed ID: 9167189
[TBL] [Abstract][Full Text] [Related]
10. Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.
Myers CE; Young RC; Chabner BA
J Clin Invest; 1975 Nov; 56(5):1231-8. PubMed ID: 1184747
[TBL] [Abstract][Full Text] [Related]
11. Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas.
Houghton JA; Weiss KD; Williams LG; Torrance PM; Houghton PJ
Biochem Pharmacol; 1986 Apr; 35(8):1351-8. PubMed ID: 3008760
[TBL] [Abstract][Full Text] [Related]
12. Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.
Van der Wilt CL; Pinedo HM; Smid K; Peters GJ
Cancer Res; 1992 Sep; 52(18):4922-8. PubMed ID: 1516048
[TBL] [Abstract][Full Text] [Related]
13. Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil.
Washtien WL
Mol Pharmacol; 1984 Jan; 25(1):171-7. PubMed ID: 6708932
[TBL] [Abstract][Full Text] [Related]
14. Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts.
Houghton JA; Williams LG; Cheshire PJ; Wainer IW; Jadaud P; Houghton PJ
Cancer Res; 1990 Jul; 50(13):3940-6. PubMed ID: 2354443
[TBL] [Abstract][Full Text] [Related]
15. Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma.
Berne MH; Gustavsson BG; Almersjö O; Spears PC; Frösing R
Cancer Chemother Pharmacol; 1986; 16(3):237-42. PubMed ID: 3698165
[TBL] [Abstract][Full Text] [Related]
16. Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate.
Danenberg KD; Danenberg PV
Mol Pharmacol; 1989 Aug; 36(2):219-23. PubMed ID: 2528057
[TBL] [Abstract][Full Text] [Related]
17. Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.
Chu E; Zinn S; Boarman D; Allegra CJ
Cancer Res; 1990 Sep; 50(18):5834-40. PubMed ID: 1697502
[TBL] [Abstract][Full Text] [Related]
18. Sequential methotrexate and 5-fluorouracil: mechanisms of synergy.
Bertino JR; Mini E; Fernandes DJ
Semin Oncol; 1983 Jun; 10(2 Suppl 2):2-5. PubMed ID: 6867754
[TBL] [Abstract][Full Text] [Related]
19. Calpain regulates thymidylate synthase-5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells.
Nabeya Y; Suzuki T; Furuya A; Koide N; Ohkoshi M; Takiguchi M; Ochiai T; Matsubara H; Hiwasa T
Cancer Sci; 2011 Aug; 102(8):1509-15. PubMed ID: 21561529
[TBL] [Abstract][Full Text] [Related]
20. Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
van der Wilt CL; Backus HH; Smid K; Comijn L; Veerman G; Wouters D; Voorn DA; Priest DG; Bunni MA; Mitchell F; Jackman AL; Jansen G; Peters GJ
Cancer Res; 2001 May; 61(9):3675-81. PubMed ID: 11325838
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
