These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

380 related articles for article (PubMed ID: 6608049)

  • 1. Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil.
    Berger SH; Hakala MT
    Mol Pharmacol; 1984 Mar; 25(2):303-9. PubMed ID: 6608049
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
    Ren Q; Van Groeningen CJ; Hardcastle A; Aherne GW; Geoffroy F; Allegra CJ; Johnston PG; Grem JL
    Oncol Res; 1997; 9(2):77-88. PubMed ID: 9167189
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.
    Spears CP; Gustavsson BG; Berne M; Frösing R; Bernstein L; Hayes AA
    Cancer Res; 1988 Oct; 48(20):5894-900. PubMed ID: 3167844
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.
    Myers CE; Young RC; Chabner BA
    J Clin Invest; 1975 Nov; 56(5):1231-8. PubMed ID: 1184747
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
    Spears CP; Shahinian AH; Moran RG; Heidelberger C; Corbett TH
    Cancer Res; 1982 Feb; 42(2):450-6. PubMed ID: 6173112
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.
    Spears CP; Gustavsson BG; Mitchell MS; Spicer D; Berne M; Bernstein L; Danenberg PV
    Cancer Res; 1984 Sep; 44(9):4144-50. PubMed ID: 6744325
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.
    Spears CP; Hayes AA; Shahinian AH; Danenberg PV; Frösing R; Gustavsson BG
    Biochem Pharmacol; 1989 Sep; 38(18):2985-93. PubMed ID: 2783153
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.
    Houghton PJ; Rahman A; Will CL; Dolnick BJ; Houghton JA
    Cancer Res; 1992 Feb; 52(3):558-65. PubMed ID: 1732043
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
    Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas.
    Houghton JA; Weiss KD; Williams LG; Torrance PM; Houghton PJ
    Biochem Pharmacol; 1986 Apr; 35(8):1351-8. PubMed ID: 3008760
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts.
    Houghton JA; Williams LG; Cheshire PJ; Wainer IW; Jadaud P; Houghton PJ
    Cancer Res; 1990 Jul; 50(13):3940-6. PubMed ID: 2354443
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ternary complex formation with 5-fluoro-2'-deoxyuridylate and the kinetic properties of thymidylate synthase from Lactobacillus leichmannii.
    Rao KN
    Indian J Biochem Biophys; 1993 Apr; 30(2):103-10. PubMed ID: 8354517
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development, characterization and application of an antibody against 5-fluoro-2'deoxyuridine-5'monophosphate, the active metabolite of 5-fluorouracil.
    Peters GJ; Laurensse E; Steinbusch HW; De Vente J; Smid K; Van der Wilt CL; Pinedo HM
    Anticancer Res; 1993; 13(4):835-9. PubMed ID: 8352551
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sequential methotrexate and 5-fluorouracil: mechanisms of synergy.
    Bertino JR; Mini E; Fernandes DJ
    Semin Oncol; 1983 Jun; 10(2 Suppl 2):2-5. PubMed ID: 6867754
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase.
    Reilly RT; Barbour KW; Dunlap RB; Berger FG
    Mol Pharmacol; 1995 Jul; 48(1):72-9. PubMed ID: 7623777
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Calcium leucovorin and 5-fluorouridine cytotoxicity.
    Berger SH; Hakala MT
    J S C Med Assoc; 1990 May; 86(5):284-9. PubMed ID: 2242115
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
    Moran RG; Spears CP; Heidelberger C
    Proc Natl Acad Sci U S A; 1979 Mar; 76(3):1456-60. PubMed ID: 108681
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase.
    Connick TJ; Reilly RT; Dunlap RB; Ellis PD
    Biochim Biophys Acta; 1994 Sep; 1208(1):118-26. PubMed ID: 8086425
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate.
    Fernandes DJ; Moroson BA; Bertino JR
    Cancer Treat Rep; 1981; 65 Suppl 1():29-35. PubMed ID: 6173121
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells.
    Chen TL; Erlichman C
    Cancer Chemother Pharmacol; 1992; 30(5):370-6. PubMed ID: 1380407
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.