547 related articles for article (PubMed ID: 6609765)
1. Role of the cellular oxidation-reduction state in methotrexate binding to dihydrofolate reductase and dissociation induced by reduced folates.
Matherly LH; Anderson LA; Goldman ID
Cancer Res; 1984 Jun; 44(6):2325-30. PubMed ID: 6609765
[TBL] [Abstract][Full Text] [Related]
2. Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate reductase by 5-formyltetrahydrofolate in Ehrlich ascites tumor cells in vitro.
Matherly LH; Fry DW; Goldman ID
Cancer Res; 1983 Jun; 43(6):2694-9. PubMed ID: 6189586
[TBL] [Abstract][Full Text] [Related]
3. Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.
Matherly LH; Barlowe CK; Goldman ID
Cancer Res; 1986 Feb; 46(2):588-93. PubMed ID: 2416428
[TBL] [Abstract][Full Text] [Related]
4. Interactions between 7-hydroxymethotrexate and methotrexate at the cellular level in the Ehrlich ascites tumor in vitro.
Fabre G; Matherly LH; Fabre I; Cano JP; Goldman ID
Cancer Res; 1984 Mar; 44(3):970-5. PubMed ID: 6692419
[TBL] [Abstract][Full Text] [Related]
5. Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.
Jolivet J; Chabner BA
J Clin Invest; 1983 Sep; 72(3):773-8. PubMed ID: 6193143
[TBL] [Abstract][Full Text] [Related]
6. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists.
Chello PL; McQueen CA; DeAngelis LM; Bertino JR
Cancer Res; 1976 Jul; 36(7 PT 1):2442-9. PubMed ID: 1277151
[TBL] [Abstract][Full Text] [Related]
7. Light activates reduction of methotrexate by NADPH in the ternary complex with Escherichia coli dihydrofolate reductase.
Chen YQ; Gulotta M; Cheung HT; Callender R
Photochem Photobiol; 1999 Jan; 69(1):77-85. PubMed ID: 10063803
[TBL] [Abstract][Full Text] [Related]
8. Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates.
Goldman ID; Matherly LH
NCI Monogr; 1987; (5):17-26. PubMed ID: 2448654
[TBL] [Abstract][Full Text] [Related]
9. Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
Cody V; Galitsky N; Luft JR; Pangborn W; Rosowsky A; Blakley RL
Biochemistry; 1997 Nov; 36(45):13897-903. PubMed ID: 9374868
[TBL] [Abstract][Full Text] [Related]
10. Intrinsic resistance to methotrexate of cultured mammalian cells in relation to the inhibition kinetics of their dihydrololate reductases.
Jackson RC; Hart LI; Harrap KR
Cancer Res; 1976 Jun; 36(6):1991-7. PubMed ID: 5189
[TBL] [Abstract][Full Text] [Related]
11. Enhanced polyglutamylation of aminopterin relative to methotrexate in the Ehrlich ascites tumor cell in vitro.
Matherly LH; Voss MK; Anderson LA; Fry DW; Goldman ID
Cancer Res; 1985 Mar; 45(3):1073-8. PubMed ID: 2578870
[TBL] [Abstract][Full Text] [Related]
12. The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.
Dams T; Auerbach G; Bader G; Jacob U; Ploom T; Huber R; Jaenicke R
J Mol Biol; 2000 Mar; 297(3):659-72. PubMed ID: 10731419
[TBL] [Abstract][Full Text] [Related]
13. Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.
Gourley DG; Schüttelkopf AW; Leonard GA; Luba J; Hardy LW; Beverley SM; Hunter WN
Nat Struct Biol; 2001 Jun; 8(6):521-5. PubMed ID: 11373620
[TBL] [Abstract][Full Text] [Related]
14. Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system.
Fry DW; Besserer JA; Boritzki TJ
Cancer Res; 1984 Aug; 44(8):3366-70. PubMed ID: 6547636
[TBL] [Abstract][Full Text] [Related]
15. Variants of human dihydrofolate reductase with substitutions at leucine-22: effect on catalytic and inhibitor binding properties.
Ercikan-Abali EA; Waltham MC; Dicker AP; Schweitzer BI; Gritsman H; Banerjee D; Bertino JR
Mol Pharmacol; 1996 Mar; 49(3):430-7. PubMed ID: 8643082
[TBL] [Abstract][Full Text] [Related]
16. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
Chen G; Wright JE; Rosowsky A
Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
[TBL] [Abstract][Full Text] [Related]
17. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
Senkovich O; Schormann N; Chattopadhyay D
Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
[TBL] [Abstract][Full Text] [Related]
18. Depletion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate by methotrexate in cultured hepatoma cells.
Rhee MS; Coward JK; Galivan J
Mol Pharmacol; 1992 Nov; 42(5):909-16. PubMed ID: 1435754
[TBL] [Abstract][Full Text] [Related]
19. NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase.
Johnson JM; Meiering EM; Wright JE; Pardo J; Rosowsky A; Wagner G
Biochemistry; 1997 Apr; 36(15):4399-411. PubMed ID: 9109647
[TBL] [Abstract][Full Text] [Related]
20. Comparative thermodynamic study of the interaction of some antifolates with dihydrofolate reductase.
Gilli RM; Sari JC; Lopez CL; Rimet OS; Briand CM
Biochim Biophys Acta; 1990 Sep; 1040(2):245-50. PubMed ID: 2400775
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]