162 related articles for article (PubMed ID: 6825083)
1. Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
Fernandes DJ; Bertino JR; Hynes JB
Cancer Res; 1983 Mar; 43(3):1117-23. PubMed ID: 6825083
[No Abstract] [Full Text] [Related]
2. A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice.
Jones TR; Calvert AH; Jackman AL; Brown SJ; Jones M; Harrap KR
Eur J Cancer (1965); 1981 Jan; 17(1):11-9. PubMed ID: 7262141
[No Abstract] [Full Text] [Related]
3. Effects of 5,8-dideazaisopteroylglutamate and its possible tri-gamma-glutamyl metabolite (5,8-dideazaisoPteGlu3) on colon adenocarcinoma, and the folate dependent enzymes thymidylate synthase and dihydrofolate reductase.
Fernandes DJ; Cardenas RM; Bertino JR; Hynes JB
Adv Exp Med Biol; 1983; 163():341-57. PubMed ID: 6688493
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics.
Jackman AL; Calvert AH; Hart LI; Harrap KR
Adv Exp Med Biol; 1984; 165 Pt B():375-8. PubMed ID: 6720434
[No Abstract] [Full Text] [Related]
5. Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
Jackman AL; Kimbell R; Aherne GW; Brunton L; Jansen G; Stephens TC; Smith MN; Wardleworth JM; Boyle FT
Clin Cancer Res; 1997 Jun; 3(6):911-21. PubMed ID: 9815766
[TBL] [Abstract][Full Text] [Related]
6. Quinazoline antifolates as inhibitors of growth, dihydrofolate reductase, and thymidylate synthetase of mouse neuroblastoma cells in culture.
Carlin SC; Rosenberg RN; VandeVenter L; Friedkin M
Mol Pharmacol; 1974 Mar; 10(2):194-203. PubMed ID: 4546895
[No Abstract] [Full Text] [Related]
7. The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
Kimbell R; Jackman AL; Boyle FT; Hardcastle A; Aherne W
Adv Exp Med Biol; 1993; 338():597-600. PubMed ID: 8304189
[No Abstract] [Full Text] [Related]
8. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA
J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414
[TBL] [Abstract][Full Text] [Related]
9. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.
Duch DS; Banks S; Dev IK; Dickerson SH; Ferone R; Heath LS; Humphreys J; Knick V; Pendergast W; Singer S
Cancer Res; 1993 Feb; 53(4):810-8. PubMed ID: 8428362
[TBL] [Abstract][Full Text] [Related]
10. The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.
Jackman AL; Kimbell R; Brown M; Brunton L; Harrap KR; Wardleworth JM; Boyle FT
Adv Exp Med Biol; 1994; 370():185-8. PubMed ID: 7660886
[No Abstract] [Full Text] [Related]
11. Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.
Jackman AL; Kimbell R; Brown M; Brunton L; Boyle FT
Anticancer Drug Des; 1995 Oct; 10(7):555-72. PubMed ID: 7495479
[TBL] [Abstract][Full Text] [Related]
12. Quinazoline analogues of folic acid as inhibitors of thymidylate synthetase from bacterial and mammalian sources.
Scanlon KJ; Moroson BA; Bertino JR; Hynes JB
Mol Pharmacol; 1979 Jul; 16(1):261-9. PubMed ID: 113660
[No Abstract] [Full Text] [Related]
13. Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent.
Jones TR; Betteridge RF; Neidle S; Jackman AL; Calvert AH
Anticancer Drug Des; 1989 Mar; 3(4):243-8. PubMed ID: 2930626
[TBL] [Abstract][Full Text] [Related]
14. Plasma nucleoside and base levels following treatment with the new thymidylate synthetase inhibitor CB 3717.
Taylor GA; Jackman AL; Calvert AH; Harrap KR
Adv Exp Med Biol; 1984; 165 Pt B():379-82. PubMed ID: 6720435
[No Abstract] [Full Text] [Related]
15. BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors.
Gibbs DD; Theti DS; Wood N; Green M; Raynaud F; Valenti M; Forster MD; Mitchell F; Bavetsias V; Henderson E; Jackman AL
Cancer Res; 2005 Dec; 65(24):11721-8. PubMed ID: 16357184
[TBL] [Abstract][Full Text] [Related]
16. Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843.
Wolfe LA; Mullin RJ; Laethem R; Blumenkopf TA; Cory M; Miller JF; Keith BR; Humphreys J; Smith GK
Bioconjug Chem; 1999; 10(1):38-48. PubMed ID: 9893962
[TBL] [Abstract][Full Text] [Related]
17. Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).
Bavetsias V; Marriott JH; Melin C; Kimbell R; Matusiak ZS; Boyle FT; Jackman AL
J Med Chem; 2000 May; 43(10):1910-26. PubMed ID: 10821704
[TBL] [Abstract][Full Text] [Related]
18. Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture.
Harrap KR
Cancer Res; 1995 Jul; 55(13):2761-8. PubMed ID: 7796401
[TBL] [Abstract][Full Text] [Related]
19. Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Bavetsias V; Jackman AL; Kimbell R; Gibson W; Boyle FT; Bisset GM
J Med Chem; 1996 Jan; 39(1):73-85. PubMed ID: 8568829
[TBL] [Abstract][Full Text] [Related]
20. A new antitumour agent, batracylin, selected by a preclinical solid tumour model.
Atassi G; Dumont P; Kabbe HJ; Yoder O
Drugs Exp Clin Res; 1988; 14(9):571-4. PubMed ID: 3229319
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
