187 related articles for article (PubMed ID: 6825198)
1. Pyrrolic and N-oxide metabolites formed from pyrrolizidine alkaloids by hepatic microsomes in vitro: relevance to in vivo hepatotoxicity.
Mattocks AR; Bird I
Chem Biol Interact; 1983 Feb; 43(2):209-22. PubMed ID: 6825198
[TBL] [Abstract][Full Text] [Related]
2. Relation of structural features to pyrrolic metabolites in livers of rats given pyrrolizidine alkaloids and derivatives.
Mattocks AR
Chem Biol Interact; 1981 Jun; 35(3):301-10. PubMed ID: 7226276
[TBL] [Abstract][Full Text] [Related]
3. The toxic effects in rats of some synthanecine carbamate and phosphate esters analogous to hepatotoxic pyrrolizidine alkaloids.
Driver HE; Mattocks AR
Chem Biol Interact; 1984 Sep; 51(2):201-18. PubMed ID: 6467455
[TBL] [Abstract][Full Text] [Related]
4. Detection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids.
Mattocks AR; Jukes R
Toxicol Lett; 1992 Oct; 63(1):47-55. PubMed ID: 1412522
[TBL] [Abstract][Full Text] [Related]
5. Metabolism and toxicity of synthetic analogues of macrocyclic diester pyrrolizidine alkaloids.
Mattocks AR; Driver HE; Barbour RH; Robins DJ
Chem Biol Interact; 1986 Apr; 58(1):95-108. PubMed ID: 3708724
[TBL] [Abstract][Full Text] [Related]
6. Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.
Culvenor CC; Edgar JA; Jago MV; Qutteridge A; Peterson JE; Smith LW
Chem Biol Interact; 1976 Mar; 12(3-4):299-324. PubMed ID: 1253333
[TBL] [Abstract][Full Text] [Related]
7. Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid.
Lin G; Cui YY; Hawes EM
Drug Metab Dispos; 2000 Dec; 28(12):1475-83. PubMed ID: 11095586
[TBL] [Abstract][Full Text] [Related]
8. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
Wang YP; Yan J; Fu PP; Chou MW
Toxicol Lett; 2005 Mar; 155(3):411-20. PubMed ID: 15649625
[TBL] [Abstract][Full Text] [Related]
9. Configuration of necine pyrroles--toxic metabolites of pyrrolizidine alkaloids.
Kedzierski B; Buhler DR
Toxicol Lett; 1985 May; 25(2):115-9. PubMed ID: 4002242
[TBL] [Abstract][Full Text] [Related]
10. Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid.
Lin G; Cui YY; Hawes EM
Drug Metab Dispos; 1998 Feb; 26(2):181-4. PubMed ID: 9456306
[TBL] [Abstract][Full Text] [Related]
11. Microsomal metabolism of pyrrolizidine alkaloids from Senecio jacobaea. Isolation and quantification of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine and N-oxides by high performance liquid chromatography.
Ramsdell HS; Kedzierski B; Buhler DR
Drug Metab Dispos; 1987; 15(1):32-6. PubMed ID: 2881756
[TBL] [Abstract][Full Text] [Related]
12. Hydrolysis and hepatotoxicity of retronecine diesters.
Mattocks AR
Toxicol Lett; 1982 Nov; 14(1-2):111-6. PubMed ID: 6818720
[TBL] [Abstract][Full Text] [Related]
13. Pyrrolic metabolites from non-toxic pyrrolizidine alkaloids.
Mattocks AR; White IN
Nat New Biol; 1971 May; 231(21):114-5. PubMed ID: 5281186
[No Abstract] [Full Text] [Related]
14. Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis.
Ruan J; Yang M; Fu P; Ye Y; Lin G
Chem Res Toxicol; 2014 Jun; 27(6):1030-9. PubMed ID: 24836403
[TBL] [Abstract][Full Text] [Related]
15. Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.
Xia Q; Yan J; Chou MW; Fu PP
Toxicol Lett; 2008 May; 178(2):77-82. PubMed ID: 18395999
[TBL] [Abstract][Full Text] [Related]
16. In vivo metabolism of retrorsine and retrorsine-N-oxide.
Chu PS; Lamé MW; Segall HJ
Arch Toxicol; 1993; 67(1):39-43. PubMed ID: 8452478
[TBL] [Abstract][Full Text] [Related]
17. Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine.
Lin G; Cui YY; Liu XQ; Wang ZT
Chem Res Toxicol; 2002 Nov; 15(11):1421-8. PubMed ID: 12437333
[TBL] [Abstract][Full Text] [Related]
18. Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation.
Xia Q; He X; Ma L; Chen S; Fu PP
Chem Res Toxicol; 2018 Jul; 31(7):619-628. PubMed ID: 29855181
[TBL] [Abstract][Full Text] [Related]
19. Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids.
Yang M; Ma J; Ruan J; Ye Y; Fu PP; Lin G
Arch Toxicol; 2019 Aug; 93(8):2197-2209. PubMed ID: 31222523
[TBL] [Abstract][Full Text] [Related]
20. Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.
Yan J; Xia Q; Chou MW; Fu PP
Toxicol Ind Health; 2008 Apr; 24(3):181-8. PubMed ID: 18842697
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
