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3. Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 2. 1,2,3,4-Tetrahydroisoquinoline-7-sulfonanilides. Blank B; Krog AJ; Weiner G; Pendleton RG J Med Chem; 1980 Aug; 23(8):837-40. PubMed ID: 7401111 [TBL] [Abstract][Full Text] [Related]
4. Tetrahydrothiadiazoloisoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase. Girard GR; Bondinell WE; Hillegass LM; Holden KG; Pendleton RG; Uzinskas I J Med Chem; 1989 Jul; 32(7):1566-71. PubMed ID: 2738892 [TBL] [Abstract][Full Text] [Related]
5. Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. Grunewald GL; Sall DJ; Monn JA J Med Chem; 1988 Apr; 31(4):824-30. PubMed ID: 3351861 [TBL] [Abstract][Full Text] [Related]
6. The effect of phenylethanolamine n-methyltransferase concentration and species difference on the inhibitory potency of SK&F 64139. Pendleton RG; Weiner G; Jenkins B Res Commun Chem Pathol Pharmacol; 1977 Jun; 17(2):201-13. PubMed ID: 406652 [TBL] [Abstract][Full Text] [Related]
7. Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1. Grunewald GL; Romero FA; Criscione KR J Med Chem; 2005 Mar; 48(6):1806-12. PubMed ID: 15771426 [TBL] [Abstract][Full Text] [Related]
8. Studies on adrenal phenylethanolamine N- methyltransferase (PNMT) with S K & F 64139, a selective inhibitor. Pendleton RG; Kaiser C; Gessner G J Pharmacol Exp Ther; 1976 Jun; 197(3):623-32. PubMed ID: 6786 [TBL] [Abstract][Full Text] [Related]
9. Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: a potential source of new drugs. Bondinell WE; Chapin FW; Frazee JS; Girard GR; Holden KG; Kaiser C; Maryanoff C; Perchonock CD; Gessner GW; Hieble JP Drug Metab Rev; 1983; 14(4):709-21. PubMed ID: 6352222 [No Abstract] [Full Text] [Related]
10. 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor. Grunewald GL; Dahanukar VH; Teoh B; Criscione KR J Med Chem; 1999 Jun; 42(11):1982-90. PubMed ID: 10354406 [TBL] [Abstract][Full Text] [Related]
11. Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. Grunewald GL; Romero FA; Seim MR; Criscione KR; Deupree JD; Spackman CC; Bylund DB Bioorg Med Chem Lett; 2005 Feb; 15(4):1143-7. PubMed ID: 15686930 [TBL] [Abstract][Full Text] [Related]
12. The long term effects of an inhibitor of phenylethanolamine N-methyltransferase upon adrenal epinephrine biosynthesis. Pendleton RG; Gessner G; Jenkins B Naunyn Schmiedebergs Arch Pharmacol; 1976 Nov; 295(2):127-33. PubMed ID: 825786 [TBL] [Abstract][Full Text] [Related]
13. Studies on the long term effects of SK&F 29661 upon adrenal catecholamines. Pendleton RG; Gessner G; Sawyer J; Hillegass L; Miller DA Naunyn Schmiedebergs Arch Pharmacol; 1982 Apr; 319(1):22-8. PubMed ID: 6125896 [TBL] [Abstract][Full Text] [Related]
14. The blockade of alpha 2-adrenoceptors by the PNMT inhibitaor SK&F 64139. Goldstein M; Saito M; Lew JY; Hieble JP; Pendleton RG Eur J Pharmacol; 1980 Oct; 67(2-3):305-8. PubMed ID: 6109637 [TBL] [Abstract][Full Text] [Related]
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16. Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. Grunewald GL; Caldwell TM; Li Q; Criscione KR J Med Chem; 1999 Aug; 42(17):3315-23. PubMed ID: 10464018 [TBL] [Abstract][Full Text] [Related]
17. Inhibitors of phenylethanolamine-N-methyltransferase. 2. Comparison of nonaromatic analogs of phenylethanolamines, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) and 2,3-dichloro-alpha-methylbenzylamine: effects on rat brain and adrenal catecholamine content and blood pressure. Liang NY; Tessel RE; Grunewald GL; Borchardt RT J Pharmacol Exp Ther; 1982 Nov; 223(2):382-7. PubMed ID: 7131293 [TBL] [Abstract][Full Text] [Related]
18. Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site. Sall DJ; Grunewald GL J Med Chem; 1987 Dec; 30(12):2208-16. PubMed ID: 3681890 [TBL] [Abstract][Full Text] [Related]
19. Studies on SK&F 29661, an organ-specific inhibitor of phenylethanolamine N-methyltransferase. Pendleton RG; Gessner G; Weiner G; Jenkins B; Sawyer J; Bondinell W; Intoccia A J Pharmacol Exp Ther; 1979 Jan; 208(1):24-30. PubMed ID: 215747 [TBL] [Abstract][Full Text] [Related]
20. Possible mechanism of action of SKF 64139 in vivo on rat adrenal and brain phenylethanolamine N-methyltransferase activity. Park DH; Ruggiero DA; Anwar M; Joh TH Biochem Pharmacol; 1988 Jan; 37(2):313-8. PubMed ID: 3342087 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]