BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

288 related articles for article (PubMed ID: 7473721)

  • 1. Framework residues 71 and 93 of the chimeric B72.3 antibody are major determinants of the conformation of heavy-chain hypervariable loops.
    Xiang J; Sha Y; Jia Z; Prasad L; Delbaere LT
    J Mol Biol; 1995 Oct; 253(3):385-90. PubMed ID: 7473721
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues.
    Wu H; Nie Y; Huse WD; Watkins JD
    J Mol Biol; 1999 Nov; 294(1):151-62. PubMed ID: 10556035
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Complementarity determining region residues aspartic acid at H55, serine at H95 and tyrosines at H97 and L96 play important roles in the B72.3 antibody-TAG72 antigen interaction.
    Xiang J; Sha Y; Prasad L; Delbaere LT
    Protein Eng; 1996 Jun; 9(6):539-43. PubMed ID: 8862555
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin.
    Giles I; Lambrianides N; Latchman D; Chen P; Chukwuocha R; Isenberg D; Rahman A
    Arthritis Res Ther; 2005; 7(1):R47-56. PubMed ID: 15642142
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Light-chain framework region residue Tyr71 of chimeric B72.3 antibody plays an important role in influencing the TAG72 antigen binding.
    Xiang J; Prasad L; Delbaere LT; Jia Z
    Protein Eng; 1999 May; 12(5):417-21. PubMed ID: 10360982
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Probing the interaction between a high-affinity single-chain Fv and a pyrimidine (6-4) pyrimidone photodimer by site-directed mutagenesis.
    Kobayashi H; Morioka H; Tobisawa K; Torizawa T; Kato K; Shimada I; Nikaido O; Stewart JD; Ohtsuka E
    Biochemistry; 1999 Jan; 38(2):532-9. PubMed ID: 9888792
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Conformations of the third hypervariable region in the VH domain of immunoglobulins.
    Morea V; Tramontano A; Rustici M; Chothia C; Lesk AM
    J Mol Biol; 1998 Jan; 275(2):269-94. PubMed ID: 9466909
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains.
    Staelens S; Desmet J; Ngo TH; Vauterin S; Pareyn I; Barbeaux P; Van Rompaey I; Stassen JM; Deckmyn H; Vanhoorelbeke K
    Mol Immunol; 2006 Mar; 43(8):1243-57. PubMed ID: 16118019
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework.
    Kügler M; Stein C; Schwenkert M; Saul D; Vockentanz L; Huber T; Wetzel SK; Scholz O; Plückthun A; Honegger A; Fey GH
    Protein Eng Des Sel; 2009 Mar; 22(3):135-47. PubMed ID: 19188138
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody.
    Fan ZC; Shan L; Goldsteen BZ; Guddat LW; Thakur A; Landolfi NF; Co MS; Vasquez M; Queen C; Ramsland PA; Edmundson AB
    J Mol Recognit; 1999; 12(1):19-32. PubMed ID: 10398393
    [TBL] [Abstract][Full Text] [Related]  

  • 11. X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
    Eigenbrot C; Randal M; Presta L; Carter P; Kossiakoff AA
    J Mol Biol; 1993 Feb; 229(4):969-95. PubMed ID: 8095303
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains.
    Honegger A; Malebranche AD; Röthlisberger D; Plückthun A
    Protein Eng Des Sel; 2009 Mar; 22(3):121-34. PubMed ID: 19136675
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Affinity maturation of a high-affinity human monoclonal antibody against the third hypervariable loop of human immunodeficiency virus: use of phage display to improve affinity and broaden strain reactivity.
    Thompson J; Pope T; Tung JS; Chan C; Hollis G; Mark G; Johnson KS
    J Mol Biol; 1996 Feb; 256(1):77-88. PubMed ID: 8609615
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Critical interactions in binding antibody NC41 to influenza N9 neuraminidase: amino acid contacts on the antibody heavy chain.
    Pruett PS; Air GM
    Biochemistry; 1998 Jul; 37(30):10660-70. PubMed ID: 9692956
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Genetic engineering of high affinity anti-human colorectal tumour mouse/human chimeric antibody.
    Xiang J; Chen Z
    Immunology; 1992 Feb; 75(2):209-16. PubMed ID: 1551684
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Functional mapping and single chain construction of the anti-cytokeratin 8 monoclonal antibody TS1.
    Holm P; Jafari R; Sundström BE
    Mol Immunol; 2007 Feb; 44(6):1075-84. PubMed ID: 16989900
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domains.
    Jung S; Spinelli S; Schimmele B; Honegger A; Pugliese L; Cambillau C; Plückthun A
    J Mol Biol; 2001 Jun; 309(3):701-16. PubMed ID: 11397090
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differences in antigen-binding affinity caused by a single amino acid substitution in the variable region of the heavy chain.
    Xiang J; Chen Z; Delbaere LT; Liu E
    Immunol Cell Biol; 1993 Aug; 71 ( Pt 4)():239-47. PubMed ID: 8225393
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent.
    Beiboer SH; Reurs A; Roovers RC; Arends JW; Whitelegg NR; Rees AR; Hoogenboom HR
    J Mol Biol; 2000 Feb; 296(3):833-49. PubMed ID: 10677285
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fine mapping of the antigen-antibody interaction of scFv215, a recombinant antibody inhibiting RNA polymerase II from Drosophila melanogaster.
    Liu Z; Song D; Kramer A; Martin AC; Dandekar T; Schneider-Mergener J; Bautz EK; Dübel S
    J Mol Recognit; 1999; 12(2):103-11. PubMed ID: 10398401
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.