These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
402 related articles for article (PubMed ID: 7489411)
1. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Haass C; Lemere CA; Capell A; Citron M; Seubert P; Schenk D; Lannfelt L; Selkoe DJ Nat Med; 1995 Dec; 1(12):1291-6. PubMed ID: 7489411 [TBL] [Abstract][Full Text] [Related]
2. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. Thinakaran G; Teplow DB; Siman R; Greenberg B; Sisodia SS J Biol Chem; 1996 Apr; 271(16):9390-7. PubMed ID: 8621605 [TBL] [Abstract][Full Text] [Related]
3. ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways. Steinhilb ML; Turner RS; Gaut JR J Neurochem; 2002 Mar; 80(6):1019-28. PubMed ID: 11953452 [TBL] [Abstract][Full Text] [Related]
4. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism. Tomita S; Kirino Y; Suzuki T J Biol Chem; 1998 Mar; 273(11):6277-84. PubMed ID: 9497354 [TBL] [Abstract][Full Text] [Related]
5. Generation of amyloid beta protein from its precursor is sequence specific. Citron M; Teplow DB; Selkoe DJ Neuron; 1995 Mar; 14(3):661-70. PubMed ID: 7695913 [TBL] [Abstract][Full Text] [Related]
6. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis. Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065 [TBL] [Abstract][Full Text] [Related]
7. Spatial-Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site. Wang J; Gleeson PA; Fourriere L Traffic; 2024 Mar; 25(3):e12932. PubMed ID: 38528836 [TBL] [Abstract][Full Text] [Related]
8. Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases. Zhang W; Espinoza D; Hines V; Innis M; Mehta P; Miller DL Biochim Biophys Acta; 1997 Nov; 1359(2):110-22. PubMed ID: 9409808 [TBL] [Abstract][Full Text] [Related]
9. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations. McPhie DL; Golde T; Eckman CB; Yager D; Brant JB; Neve RL Brain Res Mol Brain Res; 2001 Dec; 97(1):103-13. PubMed ID: 11744168 [TBL] [Abstract][Full Text] [Related]
10. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein. McConlogue L; Castellano F; deWit C; Schenk D; Maltese WA J Biol Chem; 1996 Jan; 271(3):1343-8. PubMed ID: 8576122 [TBL] [Abstract][Full Text] [Related]
11. The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells. Kuentzel SL; Ali SM; Altman RA; Greenberg BD; Raub TJ Biochem J; 1993 Oct; 295 ( Pt 2)(Pt 2):367-78. PubMed ID: 8240235 [TBL] [Abstract][Full Text] [Related]
12. Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. Ancolio K; Marambaud P; Dauch P; Checler F J Neurochem; 1997 Dec; 69(6):2494-9. PubMed ID: 9375682 [TBL] [Abstract][Full Text] [Related]
13. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Vassar R; Bennett BD; Babu-Khan S; Kahn S; Mendiaz EA; Denis P; Teplow DB; Ross S; Amarante P; Loeloff R; Luo Y; Fisher S; Fuller J; Edenson S; Lile J; Jarosinski MA; Biere AL; Curran E; Burgess T; Louis JC; Collins F; Treanor J; Rogers G; Citron M Science; 1999 Oct; 286(5440):735-41. PubMed ID: 10531052 [TBL] [Abstract][Full Text] [Related]
14. Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability. De Jonghe C; Esselens C; Kumar-Singh S; Craessaerts K; Serneels S; Checler F; Annaert W; Van Broeckhoven C; De Strooper B Hum Mol Genet; 2001 Aug; 10(16):1665-71. PubMed ID: 11487570 [TBL] [Abstract][Full Text] [Related]
15. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization. Gandhi S; Refolo LM; Sambamurti K J Mol Neurosci; 2004; 24(1):137-43. PubMed ID: 15314262 [TBL] [Abstract][Full Text] [Related]
16. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice. Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071 [TBL] [Abstract][Full Text] [Related]
17. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells. Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM Biochemistry; 1999 Jul; 38(30):9728-34. PubMed ID: 10423252 [TBL] [Abstract][Full Text] [Related]
18. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. Skovronsky DM; Moore DB; Milla ME; Doms RW; Lee VM J Biol Chem; 2000 Jan; 275(4):2568-75. PubMed ID: 10644715 [TBL] [Abstract][Full Text] [Related]
19. Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways. Perez RG; Squazzo SL; Koo EH J Biol Chem; 1996 Apr; 271(15):9100-7. PubMed ID: 8621560 [TBL] [Abstract][Full Text] [Related]
20. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets. Evin G; Zhu A; Holsinger RM; Masters CL; Li QX J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]