BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 7493924)

  • 1. Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.
    Ellis SW; Hayhurst GP; Smith G; Lightfoot T; Wong MM; Simula AP; Ackland MJ; Sternberg MJ; Lennard MS; Tucker GT
    J Biol Chem; 1995 Dec; 270(49):29055-8. PubMed ID: 7493924
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.
    Ellis SW; Hayhurst GP; Lightfoot T; Smith G; Harlow J; Rowland-Yeo K; Larsson C; Mahling J; Lim CK; Wolf CR; Blackburn MG; Lennard MS; Tucker GT
    Biochem J; 2000 Feb; 345 Pt 3(Pt 3):565-71. PubMed ID: 10642515
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.
    Mackman R; Tschirret-Guth RA; Smith G; Hayhurst GP; Ellis SW; Lennard MS; Tucker GT; Wolf CR; Ortiz de Montellano PR
    Arch Biochem Biophys; 1996 Jul; 331(1):134-40. PubMed ID: 8660692
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A predictive model for substrates of cytochrome P450-debrisoquine (2D6).
    Koymans L; Vermeulen NP; van Acker SA; te Koppele JM; Heykants JJ; Lavrijsen K; Meuldermans W; Donné-Op den Kelder GM
    Chem Res Toxicol; 1992; 5(2):211-9. PubMed ID: 1379482
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
    Guengerich FP; Miller GP; Hanna IH; Martin MV; Léger S; Black C; Chauret N; Silva JM; Trimble LA; Yergey JA; Nicoll-Griffith DA
    Biochemistry; 2002 Sep; 41(36):11025-34. PubMed ID: 12206675
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.
    Hayhurst GP; Harlow J; Chowdry J; Gross E; Hilton E; Lennard MS; Tucker GT; Ellis SW
    Biochem J; 2001 Apr; 355(Pt 2):373-9. PubMed ID: 11284724
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.
    Modi S; Paine MJ; Sutcliffe MJ; Lian LY; Primrose WU; Wolf CR; Roberts GC
    Biochemistry; 1996 Apr; 35(14):4540-50. PubMed ID: 8605204
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.
    Ellis SW; Rowland K; Ackland MJ; Rekka E; Simula AP; Lennard MS; Wolf CR; Tucker GT
    Biochem J; 1996 Jun; 316 ( Pt 2)(Pt 2):647-54. PubMed ID: 8687412
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.
    Paine MJ; McLaughlin LA; Flanagan JU; Kemp CA; Sutcliffe MJ; Roberts GC; Wolf CR
    J Biol Chem; 2003 Feb; 278(6):4021-7. PubMed ID: 12446689
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
    McLaughlin LA; Paine MJ; Kemp CA; Maréchal JD; Flanagan JU; Ward CJ; Sutcliffe MJ; Roberts GC; Wolf CR
    J Biol Chem; 2005 Nov; 280(46):38617-24. PubMed ID: 16162505
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Critical residues involved in FMN binding and catalytic activity in cytochrome P450BM-3.
    Klein ML; Fulco AJ
    J Biol Chem; 1993 Apr; 268(10):7553-61. PubMed ID: 8463285
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building.
    Koymans LM; Vermeulen NP; Baarslag A; Donné-Op den Kelder GM
    J Comput Aided Mol Des; 1993 Jun; 7(3):281-9. PubMed ID: 8377025
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A refined substrate model for human cytochrome P450 2D6.
    de Groot MJ; Bijloo GJ; Martens BJ; van Acker FA; Vermeulen NP
    Chem Res Toxicol; 1997 Jan; 10(1):41-8. PubMed ID: 9074801
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation.
    Islam SA; Wolf CR; Lennard MS; Sternberg MJ
    Carcinogenesis; 1991 Dec; 12(12):2211-9. PubMed ID: 1747920
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108.
    de Groot MJ; Vermeulen NP; Kramer JD; van Acker FA; Donné-Op den Kelder GM
    Chem Res Toxicol; 1996; 9(7):1079-91. PubMed ID: 8902262
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.
    Hanna IH; Krauser JA; Cai H; Kim MS; Guengerich FP
    J Biol Chem; 2001 Oct; 276(43):39553-61. PubMed ID: 11509577
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity.
    Hanna IH; Kim MS; Guengerich FP
    Arch Biochem Biophys; 2001 Sep; 393(2):255-61. PubMed ID: 11556812
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast.
    Ellis SW; Ching MS; Watson PF; Henderson CJ; Simula AP; Lennard MS; Tucker GT; Woods HF
    Biochem Pharmacol; 1992 Aug; 44(4):617-20. PubMed ID: 1510710
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
    Guengerich FP; Hanna IH; Martin MV; Gillam EM
    Biochemistry; 2003 Feb; 42(5):1245-53. PubMed ID: 12564927
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
    Flanagan JU; Maréchal JD; Ward R; Kemp CA; McLaughlin LA; Sutcliffe MJ; Roberts GC; Paine MJ; Wolf CR
    Biochem J; 2004 Jun; 380(Pt 2):353-60. PubMed ID: 14992686
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.