200 related articles for article (PubMed ID: 7494828)
1. Species dependent esterase activities for hydrolysis of an anti-HIV prodrug glycovir and bioavailability of active SC-48334.
Cook CS; Karabatsos PJ; Schoenhard GL; Karim A
Pharm Res; 1995 Aug; 12(8):1158-64. PubMed ID: 7494828
[TBL] [Abstract][Full Text] [Related]
2. Species differences in the disposition of propranolol prodrugs derived from hydrolase activity in intestinal mucosa.
Yoshigae Y; Imai T; Aso T; Otagiri M
Life Sci; 1998; 62(14):1231-41. PubMed ID: 9570338
[TBL] [Abstract][Full Text] [Related]
3. Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies.
Prueksaritanont T; Gorham LM; Ellis JD; Fernandez-Metzler C; Deluna P; Gehret JR; Strong KL; Hochman JH; Askew BC; Duggan ME; Gilbert JD; Lin JH; Vyas KP
Drug Metab Dispos; 1996 Nov; 24(11):1263-71. PubMed ID: 8937862
[TBL] [Abstract][Full Text] [Related]
4. Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Shaw JP; Sueoko CM; Oliyai R; Lee WA; Arimilli MN; Kim CU; Cundy KC
Pharm Res; 1997 Dec; 14(12):1824-9. PubMed ID: 9453075
[TBL] [Abstract][Full Text] [Related]
5. In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate.
Prueksaritanont T; Gorham LM; Breslin MJ; Hutchinson JH; Hartman GD; Vyas KP; Baillie TA
Drug Metab Dispos; 1997 Aug; 25(8):978-84. PubMed ID: 9280406
[TBL] [Abstract][Full Text] [Related]
6. Nonclinical pharmacokinetics of BMS-292655, a water-soluble prodrug of the antifungal ravuconazole.
Knipe JO; Mosure KW
Biopharm Drug Dispos; 2008 Jul; 29(5):270-9. PubMed ID: 18548464
[TBL] [Abstract][Full Text] [Related]
7. In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid), a potent metabotropic glutamate receptor antagonist.
Nakamura M; Kawakita Y; Yasuhara A; Fukasawa Y; Yoshida K; Sakagami K; Nakazato A
Drug Metab Dispos; 2006 Mar; 34(3):369-74. PubMed ID: 16326817
[TBL] [Abstract][Full Text] [Related]
8. Prodrugs to improve the oral bioavailability of a diacidic nonpeptide angiotensin II antagonist.
Aungst BJ; Blake JA; Rogers NJ; Saitoh H; Hussain MA; Ensinger CL; Pruitt JR
Pharm Res; 1995 May; 12(5):763-7. PubMed ID: 7479565
[TBL] [Abstract][Full Text] [Related]
9. Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine.
Ohura K; Soejima T; Nogata R; Adachi Y; Ninomiya S; Imai T
J Pharm Sci; 2012 Sep; 101(9):3264-74. PubMed ID: 22628163
[TBL] [Abstract][Full Text] [Related]
10. Species-dependent and site-specific intestinal metabolism of ester prodrugs.
Van Gelder J; Shafiee M; De Clercq E; Penninckx F; Van den Mooter G; Kinget R; Augustijns P
Int J Pharm; 2000 Sep; 205(1-2):93-100. PubMed ID: 11000545
[TBL] [Abstract][Full Text] [Related]
11. Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.
Nishimuta H; Houston JB; Galetin A
Drug Metab Dispos; 2014 Sep; 42(9):1522-31. PubMed ID: 24994071
[TBL] [Abstract][Full Text] [Related]
12. A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug.
Okudaira N; Tatebayashi T; Speirs GC; Komiya I; Sugiyama Y
J Pharmacol Exp Ther; 2000 Aug; 294(2):580-7. PubMed ID: 10900235
[TBL] [Abstract][Full Text] [Related]
13. Stereoselective disposition of flurbiprofen from a mutual prodrug with a histamine H2-antagonist to reduce gastrointestinal lesions in the rat.
Fukuhara A; Imai T; Otagiri M
Chirality; 1996; 8(7):494-502. PubMed ID: 8970747
[TBL] [Abstract][Full Text] [Related]
14. [Evaluation of the Oral Absorption of Ester-type Prodrugs].
Ohura K
Yakugaku Zasshi; 2020; 140(3):369-376. PubMed ID: 32115554
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.
Van Gelder J; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1999 Jul; 16(7):1035-40. PubMed ID: 10450927
[TBL] [Abstract][Full Text] [Related]
16. Species difference and characterization of intestinal esterase on the hydrolizing activity of ester-type drugs.
Inoue M; Morikawa M; Tsuboi M; Sugiura M
Jpn J Pharmacol; 1979 Feb; 29(1):9-16. PubMed ID: 582323
[TBL] [Abstract][Full Text] [Related]
17. Metabolism and pharmacokinetics of a double prodrug of ganciclovir in the rat and monkey.
Krasny HC; Beauchamp L; Krenitsky TA; de Miranda P
Drug Metab Dispos; 1995 Nov; 23(11):1242-7. PubMed ID: 8591725
[TBL] [Abstract][Full Text] [Related]
18. Species differences in stereoselective hydrolase activity in intestinal mucosa.
Yoshigae Y; Imai T; Horita A; Matsukane H; Otagiri M
Pharm Res; 1998 Apr; 15(4):626-31. PubMed ID: 9587961
[TBL] [Abstract][Full Text] [Related]
19. The use of esters as prodrugs for oral delivery of beta-lactam antibiotics.
Mizen L; Burton G
Pharm Biotechnol; 1998; 11():345-65. PubMed ID: 9760687
[TBL] [Abstract][Full Text] [Related]
20. Enhancement of the oral bioavailability of phenytoin by N-acetylation and absorptive characteristics.
Ogiso T; Tanino T; Kawaratani D; Iwaki M; Tanabe G; Muraoka O
Biol Pharm Bull; 1998 Oct; 21(10):1084-9. PubMed ID: 9821815
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]