266 related articles for article (PubMed ID: 7530622)
1. The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans.
Rodrigues AD; Ferrero JL; Amann MT; Rotert GA; Cepa SP; Surber BW; Machinist JM; Tich NR; Sullivan JP; Garvey DS
Drug Metab Dispos; 1994; 22(5):788-98. PubMed ID: 7530622
[TBL] [Abstract][Full Text] [Related]
2. In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation.
Rodrigues AD; Kukulka MJ; Ferrero JL; Cashman JR
Drug Metab Dispos; 1995 Oct; 23(10):1143-52. PubMed ID: 8654204
[TBL] [Abstract][Full Text] [Related]
3. Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey.
Sharer JE; Shipley LA; Vandenbranden MR; Binkley SN; Wrighton SA
Drug Metab Dispos; 1995 Nov; 23(11):1231-41. PubMed ID: 8591724
[TBL] [Abstract][Full Text] [Related]
4. The role of cytochromes P-450 and flavin-containing monooxygenase in the metabolism of (S)-nicotine by rabbit lung.
Williams DE; Shigenaga MK; Castagnoli N
Drug Metab Dispos; 1990; 18(4):418-28. PubMed ID: 1976062
[TBL] [Abstract][Full Text] [Related]
5. In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification.
Kumar GN; Jayanti V; Lee RD; Whittern DN; Uchic J; Thomas S; Johnson P; Grabowski B; Sham H; Betebenner D; Kempf DJ; Denissen JF
Drug Metab Dispos; 1999 Jan; 27(1):86-91. PubMed ID: 9884314
[TBL] [Abstract][Full Text] [Related]
6. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.
Arneric SP; Sullivan JP; Briggs CA; Donnelly-Roberts D; Anderson DJ; Raszkiewicz JL; Hughes ML; Cadman ED; Adams P; Garvey DS
J Pharmacol Exp Ther; 1994 Jul; 270(1):310-8. PubMed ID: 7518514
[TBL] [Abstract][Full Text] [Related]
7. Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices.
Steensma A; Beamand JA; Walters DG; Price RJ; Lake BG
Xenobiotica; 1994 Sep; 24(9):893-907. PubMed ID: 7810171
[TBL] [Abstract][Full Text] [Related]
8. Comparative studies of the in vitro metabolism and covalent binding of 14C-benzene by liver slices and microsomal fraction of mouse, rat, and human.
Brodfuehrer JI; Chapman DE; Wilke TJ; Powis G
Drug Metab Dispos; 1990; 18(1):20-7. PubMed ID: 1970773
[TBL] [Abstract][Full Text] [Related]
9. Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase.
Acheampong AA; Chien DS; Lam S; Vekich S; Breau A; Usansky J; Harcourt D; Munk SA; Nguyen H; Garst M; Tang-Liu D
Xenobiotica; 1996 Oct; 26(10):1035-55. PubMed ID: 8905918
[TBL] [Abstract][Full Text] [Related]
10. Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.
Onderwater RC; Commandeur JN; Vermeulen NP
Toxicology; 2004 Apr; 197(2):81-91. PubMed ID: 15003319
[TBL] [Abstract][Full Text] [Related]
11. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
[TBL] [Abstract][Full Text] [Related]
12. Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices.
Ekins S; Williams JA; Murray GI; Burke MD; Marchant NC; Engeset J; Hawksworth GM
Drug Metab Dispos; 1996 Sep; 24(9):990-5. PubMed ID: 8886609
[TBL] [Abstract][Full Text] [Related]
13. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
Beland FA
Toxic Rep Ser; 1999 Aug; (59):1-66, A1-E7. PubMed ID: 11803702
[TBL] [Abstract][Full Text] [Related]
14. Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.
Lin JH; Chiba M; Balani SK; Chen IW; Kwei GY; Vastag KJ; Nishime JA
Drug Metab Dispos; 1996 Oct; 24(10):1111-20. PubMed ID: 8894513
[TBL] [Abstract][Full Text] [Related]
15. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
Brioni JD; O'Neill AB; Kim DJ; Buckley MJ; Decker MW; Arneric SP
J Pharmacol Exp Ther; 1994 Oct; 271(1):353-61. PubMed ID: 7965735
[TBL] [Abstract][Full Text] [Related]
16. Biotransformation of a somatostatin analogue in precision-cut liver and kidney slices from rat, dog and man.
Connors MS; Larrauri A; Dannecker R; Nufer R; Brendel K; Vickers AE
Xenobiotica; 1996 Feb; 26(2):133-41. PubMed ID: 8867998
[TBL] [Abstract][Full Text] [Related]
17. Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human.
Prueksaritanont T; Balani SK; Dwyer LM; Ellis JD; Kauffman LR; Varga SL; Pitzenberger SM; Theoharides AD
Drug Metab Dispos; 1995 Jul; 23(7):688-95. PubMed ID: 7587955
[TBL] [Abstract][Full Text] [Related]
18. Characterization of [3H]ABT-418: a novel cholinergic channel ligand.
Anderson DJ; Williams M; Pauly JR; Raszkiewicz JL; Campbell JE; Rotert G; Surber B; Thomas SB; Wasicak J; Arneric SP
J Pharmacol Exp Ther; 1995 Jun; 273(3):1434-41. PubMed ID: 7791118
[TBL] [Abstract][Full Text] [Related]
19. In vitro metabolism of a potent HIV-protease inhibitor (141W94) using rat, monkey and human liver S9.
Singh R; Chang SY; Taylor LC
Rapid Commun Mass Spectrom; 1996; 10(9):1019-26. PubMed ID: 8755234
[TBL] [Abstract][Full Text] [Related]
20. Flavin-containing monooxygenase-mediated N-oxidation of the M(1)-muscarinic agonist xanomeline.
Ring BJ; Wrighton SA; Aldridge SL; Hansen K; Haehner B; Shipley LA
Drug Metab Dispos; 1999 Oct; 27(10):1099-103. PubMed ID: 10497134
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]