These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

221 related articles for article (PubMed ID: 7536024)

  • 1. Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase.
    Maliepaard M; Wolfs A; Groot SE; de Mol NJ; Janssen LH
    Br J Cancer; 1995 Apr; 71(4):836-9. PubMed ID: 7536024
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.
    Bailey SM; Wyatt MD; Friedlos F; Hartley JA; Knox RJ; Lewis AD; Workman P
    Br J Cancer; 1997; 76(12):1596-603. PubMed ID: 9413948
    [TBL] [Abstract][Full Text] [Related]  

  • 3. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.
    Plumb JA; Gerritsen M; Workman P
    Br J Cancer; 1994 Dec; 70(6):1136-43. PubMed ID: 7526885
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
    Walton MI; Smith PJ; Workman P
    Cancer Commun; 1991 Jul; 3(7):199-206. PubMed ID: 1714284
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase.
    Phillips RM
    Biochem Pharmacol; 1996 Dec; 52(11):1711-8. PubMed ID: 8986133
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.
    Plumb JA; Workman P
    Int J Cancer; 1994 Jan; 56(1):134-9. PubMed ID: 8262670
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.
    Smitskamp-Wilms E; Hendriks HR; Peters GJ
    Gen Pharmacol; 1996 Apr; 27(3):421-9. PubMed ID: 8723519
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.
    Fitzsimmons SA; Workman P; Grever M; Paull K; Camalier R; Lewis AD
    J Natl Cancer Inst; 1996 Mar; 88(5):259-69. PubMed ID: 8614004
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites.
    Bailey SM; Lewis AD; Knox RJ; Patterson LH; Fisher GR; Workman P
    Biochem Pharmacol; 1998 Sep; 56(5):613-21. PubMed ID: 9783730
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression.
    Smitskamp-Wilms E; Peters GJ; Pinedo HM; van Ark-Otte J; Giaccone G
    Biochem Pharmacol; 1994 Apr; 47(8):1325-32. PubMed ID: 7514407
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
    Walton MI; Sugget N; Workman P
    Int J Radiat Oncol Biol Phys; 1992; 22(4):643-7. PubMed ID: 1544831
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
    Plumb JA; Gerritsen M; Milroy R; Thomson P; Workman P
    Int J Radiat Oncol Biol Phys; 1994 May; 29(2):295-9. PubMed ID: 8195022
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents.
    Begleiter A; Leith MK; Curphey TJ
    Br J Cancer Suppl; 1996 Jul; 27():S9-14. PubMed ID: 8763837
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species.
    Bailey SM; Lewis AD; Patterson LH; Fisher GR; Knox RJ; Workman P
    Biochem Pharmacol; 2001 Aug; 62(4):461-8. PubMed ID: 11448456
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
    Doherty GP; Leith MK; Wang X; Curphey TJ; Begleiter A
    Br J Cancer; 1998 Apr; 77(8):1241-52. PubMed ID: 9579829
    [TBL] [Abstract][Full Text] [Related]  

  • 16. DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
    Walton MI; Bibby MC; Double JA; Plumb JA; Workman P
    Eur J Cancer; 1992; 28A(10):1597-600. PubMed ID: 1389472
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J; Oleschuk CJ; Guziec F; Guziec L; Fiterman DJ; Monterrosa C; Begleiter A
    Cancer Chemother Pharmacol; 2002 Feb; 49(2):101-10. PubMed ID: 11862423
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?
    Robertson N; Stratford IJ; Houlbrook S; Carmichael J; Adams GE
    Biochem Pharmacol; 1992 Aug; 44(3):409-12. PubMed ID: 1510692
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro.
    Jaffar M; Naylor MA; Robertson N; Lockyer SD; Phillips RM; Everett SA; Adams GE; Stratford IJ
    Anticancer Drug Des; 1998 Mar; 13(2):105-23. PubMed ID: 9524554
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.
    Roberts JJ; Marchbank T; Kotsaki-Kovatsi VP; Boland MP; Friedlos F; Knox RJ
    Biochem Pharmacol; 1989 Nov; 38(22):4137-43. PubMed ID: 2480794
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.