BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

206 related articles for article (PubMed ID: 7543044)

  • 1. The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc.
    Kaburagi Y; Yamamoto-Honda R; Tobe K; Ueki K; Yachi M; Akanuma Y; Stephens RM; Kaplan D; Yazaki Y; Kadowaki T
    Endocrinology; 1995 Aug; 136(8):3437-43. PubMed ID: 7543044
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.
    Tobe K; Matuoka K; Tamemoto H; Ueki K; Kaburagi Y; Asai S; Noguchi T; Matsuda M; Tanaka S; Hattori S
    J Biol Chem; 1993 May; 268(15):11167-71. PubMed ID: 8388384
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of a NPXY motif in growth factor receptor-bound protein 14 (Grb14) and its interaction with the phosphotyrosine-binding (PTB) domain of IRS-1.
    Rajala RV; Chan MD
    Biochemistry; 2005 Jun; 44(22):7929-35. PubMed ID: 15924411
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation.
    Harada S; Smith RM; Smith JA; White MF; Jarett L
    J Biol Chem; 1996 Nov; 271(47):30222-6. PubMed ID: 8939974
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of SHC as a substrate of the insulin receptor kinase distinct from the GAP-associated 62 kDa tyrosine phosphoprotein.
    Kovacina KS; Roth RA
    Biochem Biophys Res Commun; 1993 May; 192(3):1303-11. PubMed ID: 7685165
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.
    Chen D; Van Horn DJ; White MF; Backer JM
    Mol Cell Biol; 1995 Sep; 15(9):4711-7. PubMed ID: 7651388
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
    Gustafson TA; He W; Craparo A; Schaub CD; O'Neill TJ
    Mol Cell Biol; 1995 May; 15(5):2500-8. PubMed ID: 7537849
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.
    Ouwens DM; van der Zon GC; Pronk GJ; Bos JL; Möller W; Cheatham B; Kahn CR; Maassen JA
    J Biol Chem; 1994 Dec; 269(52):33116-22. PubMed ID: 7806540
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.
    Noguchi T; Matozaki T; Horita K; Fujioka Y; Kasuga M
    Mol Cell Biol; 1994 Oct; 14(10):6674-82. PubMed ID: 7935386
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes.
    Valverde AM; Lorenzo M; Pons S; White MF; Benito M
    Mol Endocrinol; 1998 May; 12(5):688-97. PubMed ID: 9605931
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.
    Yonezawa K; Ando A; Kaburagi Y; Yamamoto-Honda R; Kitamura T; Hara K; Nakafuku M; Okabayashi Y; Kadowaki T; Kaziro Y
    J Biol Chem; 1994 Feb; 269(6):4634-40. PubMed ID: 7508445
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Differential modulation of the tyrosine phosphorylation state of the insulin receptor by IRS (insulin receptor subunit) proteins.
    Solow BT; Harada S; Goldstein BJ; Smith JA; White MF; Jarett L
    Mol Endocrinol; 1999 Oct; 13(10):1784-98. PubMed ID: 10517679
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site.
    van der Geer P; Wiley S; Pawson T
    Oncogene; 1999 May; 18(20):3071-5. PubMed ID: 10340378
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.
    Bossenmaier B; Strack V; Stoyanov B; Krützfeldt J; Beck A; Lehmann R; Kellerer M; Klein H; Ullrich A; Lammers R; Häring HU
    Diabetes; 2000 Jun; 49(6):889-95. PubMed ID: 10866039
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.
    Krook A; Whitehead JP; Dobson SP; Griffiths MR; Ouwens M; Baker C; Hayward AC; Sen SK; Maassen JA; Siddle K; Tavaré JM; O'Rahilly S
    J Biol Chem; 1997 Nov; 272(48):30208-14. PubMed ID: 9374504
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.
    Sasaoka T; Draznin B; Leitner JW; Langlois WJ; Olefsky JM
    J Biol Chem; 1994 Apr; 269(14):10734-8. PubMed ID: 8144662
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
    Skolnik EY; Lee CH; Batzer A; Vicentini LM; Zhou M; Daly R; Myers MJ; Backer JM; Ullrich A; White MF
    EMBO J; 1993 May; 12(5):1929-36. PubMed ID: 8491186
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor.
    Kaburagi Y; Momomura K; Yamamoto-Honda R; Tobe K; Tamori Y; Sakura H; Akanuma Y; Yazaki Y; Kadowaki T
    J Biol Chem; 1993 Aug; 268(22):16610-22. PubMed ID: 8393870
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling.
    Goalstone ML; Leitner JW; Berhanu P; Sharma PM; Olefsky JM; Draznin B
    J Biol Chem; 2001 Apr; 276(16):12805-12. PubMed ID: 11278505
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells.
    Niessen M; Jaschinski F; Item F; McNamara MP; Spinas GA; Trüb T
    Exp Cell Res; 2007 Feb; 313(4):805-15. PubMed ID: 17222824
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.