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4. Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. Hutchinson JH; Riendeau D; Brideau C; Chan C; Falgueyret JP; Guay J; Jones TR; Lépine C; Macdonald D; McFarlane CS J Med Chem; 1994 Apr; 37(8):1153-64. PubMed ID: 8164257 [TBL] [Abstract][Full Text] [Related]
5. 4-acylaminophenol derivatives as novel lipoxygenase inhibitors: synthesis and inhibitory effect on 5-lipoxygenase and leukotriene B4 production. Kikuchi M; Hashimura Y; Tsuzurahara K; Nagasawa M; Inoue H; Taniguchi T; Uchida T Biol Pharm Bull; 1994 Aug; 17(8):1038-46. PubMed ID: 7820104 [TBL] [Abstract][Full Text] [Related]
6. Ca2+ ionophore A23187-stimulated secretion of azurophil granules in human polymorphonuclear leukocytes is largely mediated by endogenously formed leukotriene B4. Hatzelmann A; Fruchtmann R; Mohrs KH; Raddatz S; Müller-Peddinghaus R Biochem Pharmacol; 1994 Jul; 48(1):31-9. PubMed ID: 8043028 [TBL] [Abstract][Full Text] [Related]
7. The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses. Kusner EJ; Buckner CK; Dea DM; DeHaas CJ; Marks RL; Krell RD Eur J Pharmacol; 1994 May; 257(3):285-92. PubMed ID: 7522174 [TBL] [Abstract][Full Text] [Related]
8. Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase. Lau CK; Bélanger PC; Dufresne C; Scheigetz J; Therien M; Fitzsimmons B; Young RN; Ford-Hutchinson AW; Riendeau D; Denis D J Med Chem; 1992 Apr; 35(7):1299-318. PubMed ID: 1313879 [TBL] [Abstract][Full Text] [Related]
9. Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model. Raychaudhuri A; Chertock H; Chovan J; Jones LS; Kimble EF; Kowalski TJ; Peppard J; White DH; Satoh Y; Roland D Naunyn Schmiedebergs Arch Pharmacol; 1997 Apr; 355(4):470-4. PubMed ID: 9109363 [TBL] [Abstract][Full Text] [Related]
10. Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-lipoxygenase inhibitor BWA4C. Hawthorne AB; Boughton-Smith NK; Whittle BJ; Hawkey CJ Gut; 1992 Apr; 33(4):513-7. PubMed ID: 1316305 [TBL] [Abstract][Full Text] [Related]
11. Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo. Tateson JE; Randall RW; Reynolds CH; Jackson WP; Bhattacherjee P; Salmon JA; Garland LG Br J Pharmacol; 1988 Jun; 94(2):528-39. PubMed ID: 2840160 [TBL] [Abstract][Full Text] [Related]
12. 4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity. Crawley GC; Briggs MT; Dowell RI; Edwards PN; Hamilton PM; Kingston JF; Oldham K; Waterson D; Whalley DP J Med Chem; 1993 Jan; 36(2):295-6. PubMed ID: 8380872 [No Abstract] [Full Text] [Related]
13. Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation. Ergün BC; Nuñez MT; Labeaga L; Ledo F; Darlington J; Bain G; Cakir B; Banoglu E Arzneimittelforschung; 2010; 60(8):497-505. PubMed ID: 20863006 [TBL] [Abstract][Full Text] [Related]
14. Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. Hutchinson JH; Riendeau D; Brideau C; Chan C; Delorme D; Denis D; Falgueyret JP; Fortin R; Guay J; Hamel P J Med Chem; 1993 Sep; 36(19):2771-87. PubMed ID: 8410991 [TBL] [Abstract][Full Text] [Related]
16. Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5-lipoxygenase. Malamas MS; Carlson RP; Grimes D; Howell R; Glaser K; Gunawan I; Nelson JA; Kanzelberger M; Shah U; Hartman DA J Med Chem; 1996 Jan; 39(1):237-45. PubMed ID: 8568813 [TBL] [Abstract][Full Text] [Related]
17. Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids. Ducharme Y; Brideau C; Dubé D; Chan CC; Falgueyret JP; Gillard JW; Guay J; Hutchinson JH; McFarlane CS; Riendeau D J Med Chem; 1994 Feb; 37(4):512-8. PubMed ID: 8120869 [TBL] [Abstract][Full Text] [Related]
18. Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase. Mano T; Stevens RW; Ando K; Nakao K; Okumura Y; Sakakibara M; Okumura T; Tamura T; Miyamoto K Bioorg Med Chem; 2003 Sep; 11(18):3879-87. PubMed ID: 12927848 [TBL] [Abstract][Full Text] [Related]
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20. Inhibition of equine mononuclear cell proliferation and leukotriene B4 synthesis by a specific 5-lipoxygenase inhibitor, A-63162. Olsen SC; Atluru D; Atluru S; McVey DS; Erickson HH Am J Vet Res; 1992 Jun; 53(6):1015-8. PubMed ID: 1320811 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]