BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

213 related articles for article (PubMed ID: 7577040)

  • 1. Thymidylate synthase and drug resistance.
    Peters GJ; van der Wilt CL; van Triest B; Codacci-Pisanelli G; Johnston PG; van Groeningen CJ; Pinedo HM
    Eur J Cancer; 1995; 31A(7-8):1299-305. PubMed ID: 7577040
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
    Peters GJ; Backus HH; Freemantle S; van Triest B; Codacci-Pisanelli G; van der Wilt CL; Smid K; Lunec J; Calvert AH; Marsh S; McLeod HL; Bloemena E; Meijer S; Jansen G; van Groeningen CJ; Pinedo HM
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):194-205. PubMed ID: 12084461
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
    Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
    van der Wilt CL; Backus HH; Smid K; Comijn L; Veerman G; Wouters D; Voorn DA; Priest DG; Bunni MA; Mitchell F; Jackman AL; Jansen G; Peters GJ
    Cancer Res; 2001 May; 61(9):3675-81. PubMed ID: 11325838
    [TBL] [Abstract][Full Text] [Related]  

  • 5. High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.
    Codacci-Pisanelli G; Van der Wilt CL; Smid K; Noordhuis P; Voorn D; Pinedo HM; Peters GJ
    Oncology; 2002; 62(4):363-70. PubMed ID: 12138245
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.
    Peters GJ; van der Wilt CL; van Groeningen CJ; Smid K; Meijer S; Pinedo HM
    J Clin Oncol; 1994 Oct; 12(10):2035-42. PubMed ID: 7931471
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.
    Van der Wilt CL; Pinedo HM; Smid K; Peters GJ
    Cancer Res; 1992 Sep; 52(18):4922-8. PubMed ID: 1516048
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparative cytotoxicity of folate-based inhibitors of thymidylate synthase and 5-fluorouracil +/- leucovorin in MGH-U1 cells.
    Erlichman C; Mitrovski B
    Cancer Chemother Pharmacol; 1994; 34(1):51-6. PubMed ID: 8174202
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
    Backus HH; Pinedo HM; Wouters D; Padrón JM; Molders N; van Der Wilt CL; van Groeningen CJ; Jansen G; Peters GJ
    Int J Cancer; 2000 Sep; 87(6):771-8. PubMed ID: 10956384
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 5-fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man.
    van der Wilt CL; van Groeningen CJ; Pinedo HM; Smid K; Hoekman K; Meijer S; Peters GJ
    J Cancer Res Clin Oncol; 1997; 123(11-12):595-601. PubMed ID: 9620216
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
    Bijnsdorp IV; Comijn EM; Padron JM; Gmeiner WH; Peters GJ
    Oncol Rep; 2007 Jul; 18(1):287-91. PubMed ID: 17549381
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat.
    van der Wilt CL; Marinelli A; Pinedo HM; Cloos J; Smid K; van de Velde CJ; Peters GJ
    Eur J Cancer; 1995; 31A(5):754-60. PubMed ID: 7640050
    [TBL] [Abstract][Full Text] [Related]  

  • 13. [Dihydropyrimidine dehydrogenase and thymidylate synthase activities in colonic cancer tissue and sensitivity to 5-fluorouracil].
    Araki S; Isomoto H; Matsumoto A; Kaihara J; Yasunaga M; Hayashi K; Yatsugi H; Yamauchi K
    Nihon Geka Gakkai Zasshi; 1999 Dec; 100(12):822. PubMed ID: 10766580
    [No Abstract]   [Full Text] [Related]  

  • 14. Novel chemical strategies for thymidylate synthase inhibition.
    Gmeiner WH
    Curr Med Chem; 2005; 12(2):191-202. PubMed ID: 15638735
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.
    Codacci-Pisanelli G; Noordhuis P; van der Wilt CL; Peters GJ
    Nucleosides Nucleotides Nucleic Acids; 2008 Jun; 27(6):733-9. PubMed ID: 18600533
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil.
    Cascinu S; Aschele C; Barni S; Debernardis D; Baldo C; Tunesi G; Catalano V; Staccioli MP; Brenna A; Muretto P; Catalano G
    Clin Cancer Res; 1999 Aug; 5(8):1996-9. PubMed ID: 10473077
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
    van der Wilt CL; Pinedo HM; Smid K; Cloos J; Noordhuis P; Peters GJ
    Semin Oncol; 1992 Apr; 19(2 Suppl 3):16-25. PubMed ID: 1532671
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts.
    Houghton JA; Williams LG; Cheshire PJ; Wainer IW; Jadaud P; Houghton PJ
    Cancer Res; 1990 Jul; 50(13):3940-6. PubMed ID: 2354443
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.
    Spears CP; Gustavsson BG; Berne M; Frösing R; Bernstein L; Hayes AA
    Cancer Res; 1988 Oct; 48(20):5894-900. PubMed ID: 3167844
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase.
    Nakamura A; Nakajima G; Okuyama R; Kuramochi H; Kondoh Y; Kanemura T; Takechi T; Yamamoto M; Hayashi K
    Gastric Cancer; 2014 Jan; 17(1):188-95. PubMed ID: 23494117
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.