BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 7578041)

  • 1. Human aldose reductase: pK of tyrosine 48 reveals the preferred ionization state for catalysis and inhibition.
    Grimshaw CE; Bohren KM; Lai CJ; Gabbay KH
    Biochemistry; 1995 Nov; 34(44):14374-84. PubMed ID: 7578041
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanism of human aldehyde reductase: characterization of the active site pocket.
    Barski OA; Gabbay KH; Grimshaw CE; Bohren KM
    Biochemistry; 1995 Sep; 34(35):11264-75. PubMed ID: 7669785
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme.
    Grimshaw CE; Bohren KM; Lai CJ; Gabbay KH
    Biochemistry; 1995 Nov; 34(44):14356-65. PubMed ID: 7578039
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme.
    Bohren KM; Grimshaw CE; Lai CJ; Harrison DH; Ringe D; Petsko GA; Gabbay KH
    Biochemistry; 1994 Mar; 33(8):2021-32. PubMed ID: 8117659
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Human aldose reductase: subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme.
    Grimshaw CE; Bohren KM; Lai CJ; Gabbay KH
    Biochemistry; 1995 Nov; 34(44):14366-73. PubMed ID: 7578040
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.
    Harrison DH; Bohren KM; Ringe D; Petsko GA; Gabbay KH
    Biochemistry; 1994 Mar; 33(8):2011-20. PubMed ID: 8117658
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.
    Ehrig T; Bohren KM; Prendergast FG; Gabbay KH
    Biochemistry; 1994 Jun; 33(23):7157-65. PubMed ID: 8003482
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hydrogen bonding interactions between aldose reductase complexed with NADP(H) and inhibitor tolrestat studied by molecular dynamics simulations and binding assay.
    Lee YS; Hodoscek M; Kador PF; Sugiyama K
    Chem Biol Interact; 2003 Feb; 143-144():307-16. PubMed ID: 12604217
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The sorbinil trap: a predicted dead-end complex confirms the mechanism of aldose reductase inhibition.
    Bohren KM; Grimshaw CE
    Biochemistry; 2000 Aug; 39(32):9967-74. PubMed ID: 10933817
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Bovine lens aldose reductase. pH-dependence of steady-state kinetic parameters and nucleotide binding.
    Liu SQ; Bhatnagar A; Srivastava SK
    J Biol Chem; 1993 Dec; 268(34):25494-9. PubMed ID: 8244985
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of aldose reductase by (2,6-dimethylphenylsulphonyl)nitromethane: possible implications for the nature of an inhibitor binding site and a cause of biphasic kinetics.
    Ward WH; Cook PN; Mirrlees DJ; Brittain DR; Preston J; Carey F; Tuffin DP; Howe R
    Adv Exp Med Biol; 1993; 328():301-11. PubMed ID: 8493907
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Kinetic and spectroscopic evidence for active site inhibition of human aldose reductase.
    Nakano T; Petrash JM
    Biochemistry; 1996 Aug; 35(34):11196-202. PubMed ID: 8780524
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.
    Ruiz F; Hazemann I; Mitschler A; Joachimiak A; Schneider T; Karplus M; Podjarny A
    Acta Crystallogr D Biol Crystallogr; 2004 Aug; 60(Pt 8):1347-54. PubMed ID: 15272156
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Stereospecific interaction of a novel spirosuccinimide type aldose reductase inhibitor, AS-3201, with aldose reductase.
    Kurono M; Fujiwara I; Yoshida K
    Biochemistry; 2001 Jul; 40(28):8216-26. PubMed ID: 11444967
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human liver aldehyde reductase: pH dependence of steady-state kinetic parameters.
    Bhatnagar A; Das B; Liu SQ; Srivastava SK
    Arch Biochem Biophys; 1991 Jun; 287(2):329-36. PubMed ID: 1654814
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding.
    Ye Q; Hyndman D; Green NC; Li L; Jia Z; Flynn TG
    Chem Biol Interact; 2001 Jan; 130-132(1-3):651-8. PubMed ID: 11306083
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Transient-state and steady-state kinetic studies of the mechanism of NADH-dependent aldehyde reduction catalyzed by xylose reductase from the yeast Candida tenuis.
    Nidetzky B; Klimacek M; Mayr P
    Biochemistry; 2001 Aug; 40(34):10371-81. PubMed ID: 11513616
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex.
    Sugiyama K; Chen Z; Lee YS; Kador PF
    Biochem Pharmacol; 2000 Feb; 59(4):329-36. PubMed ID: 10644040
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism.
    Bohren KM; Brownlee JM; Milne AC; Gabbay KH; Harrison DH
    Biochim Biophys Acta; 2005 May; 1748(2):201-12. PubMed ID: 15769597
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Residues affecting the catalysis and inhibition of rat lens aldose reductase.
    Carper DA; Hohman TC; Old SE
    Biochim Biophys Acta; 1995 Jan; 1246(1):67-73. PubMed ID: 7811733
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.