196 related articles for article (PubMed ID: 7600921)
1. Regioselective and stereoselective oxidation of metoprolol and bufuralol catalyzed by microsomes containing cDNA-expressed human P4502D6.
Mautz DS; Nelson WL; Shen DD
Drug Metab Dispos; 1995 Apr; 23(4):513-7. PubMed ID: 7600921
[TBL] [Abstract][Full Text] [Related]
2. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
Yamazaki H; Guo Z; Persmark M; Mimura M; Inoue K; Guengerich FP; Shimada T
Mol Pharmacol; 1994 Sep; 46(3):568-77. PubMed ID: 7935340
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of the enantioselective oxidative metabolism of metoprolol by verapamil in human liver microsomes.
Kim M; Shen DD; Eddy AC; Nelson WL; Roskos LK
Drug Metab Dispos; 1993; 21(2):309-17. PubMed ID: 8097702
[TBL] [Abstract][Full Text] [Related]
4. Regioselectivity and enantioselectivity of metoprolol oxidation by two variants of cDNA-expressed P4502D6.
Mautz DS; Shen DD; Nelson WL
Pharm Res; 1995 Dec; 12(12):2053-6. PubMed ID: 8786988
[TBL] [Abstract][Full Text] [Related]
5. Enantioselective and diastereoselective hydroxylation of bufuralol. Absolute configuration of the 7-(1-hydroxyethyl)-2-[1-hydroxy-2-(tert-butylamino)ethyl]benzofurans, the benzylic hydroxylation metabolites.
Weerawarna SA; Geisshüsler SM; Murthy SS; Nelson WL
J Med Chem; 1991 Oct; 34(10):3091-7. PubMed ID: 1681107
[TBL] [Abstract][Full Text] [Related]
6. The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation.
Meyer UA; Gut J; Kronbach T; Skoda C; Meier UT; Catin T; Dayer P
Xenobiotica; 1986 May; 16(5):449-64. PubMed ID: 2874666
[TBL] [Abstract][Full Text] [Related]
7. Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.
Otton SV; Crewe HK; Lennard MS; Tucker GT; Woods HF
J Pharmacol Exp Ther; 1988 Oct; 247(1):242-7. PubMed ID: 3171974
[TBL] [Abstract][Full Text] [Related]
8. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
Niwa T; Shiraga T; Mitani Y; Terakawa M; Tokuma Y; Kagayama A
Drug Metab Dispos; 2000 Sep; 28(9):1128-34. PubMed ID: 10950860
[TBL] [Abstract][Full Text] [Related]
9. Metabolic kinetics of pseudoracemic propranolol in human liver microsomes. Enantioselectivity and quinidine inhibition.
Marathe PH; Shen DD; Nelson WL
Drug Metab Dispos; 1994; 22(2):237-47. PubMed ID: 8013280
[TBL] [Abstract][Full Text] [Related]
10. Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.
Ellis SW; Rowland K; Ackland MJ; Rekka E; Simula AP; Lennard MS; Wolf CR; Tucker GT
Biochem J; 1996 Jun; 316 ( Pt 2)(Pt 2):647-54. PubMed ID: 8687412
[TBL] [Abstract][Full Text] [Related]
11. Relationship between oxidative metabolism of 2-acetylaminofluorene, debrisoquine, bufuralol, and aldrin in human liver microsomes.
McManus ME; Boobis AR; Minchin RF; Schwartz DM; Murray S; Davies DS; Thorgeirsson SS
Cancer Res; 1984 Dec; 44(12 Pt 1):5692-7. PubMed ID: 6498831
[TBL] [Abstract][Full Text] [Related]
12. Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s.
Narimatsu S; Takemi C; Kuramoto S; Tsuzuki D; Hichiya H; Tamagake K; Yamamoto S
Chirality; 2003 May; 15(4):333-9. PubMed ID: 12666241
[TBL] [Abstract][Full Text] [Related]
13. Pharmacokinetic interaction between verapamil and metoprolol in the dog. Stereochemical aspects.
Murthy SS; Nelson WL; Shen DD; Power JM; Cahill CM; McLean AJ
Drug Metab Dispos; 1991; 19(6):1093-100. PubMed ID: 1687016
[TBL] [Abstract][Full Text] [Related]
14. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
Coleman T; Ellis SW; Martin IJ; Lennard MS; Tucker GT
J Pharmacol Exp Ther; 1996 May; 277(2):685-90. PubMed ID: 8627546
[TBL] [Abstract][Full Text] [Related]
15. Regiochemistry and substrate stereoselectivity of O-demethylation of verapamil in the presence of the microsomal fraction from rat and human liver.
Nelson WL; Olsen LD; Beitner DB; Pallow RJ
Drug Metab Dispos; 1988; 16(2):184-8. PubMed ID: 2898330
[TBL] [Abstract][Full Text] [Related]
16. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.
Ellis SW; Hayhurst GP; Lightfoot T; Smith G; Harlow J; Rowland-Yeo K; Larsson C; Mahling J; Lim CK; Wolf CR; Blackburn MG; Lennard MS; Tucker GT
Biochem J; 2000 Feb; 345 Pt 3(Pt 3):565-71. PubMed ID: 10642515
[TBL] [Abstract][Full Text] [Related]
17. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1.
Gallagher EP; Wienkers LC; Stapleton PL; Kunze KL; Eaton DL
Cancer Res; 1994 Jan; 54(1):101-8. PubMed ID: 8261428
[TBL] [Abstract][Full Text] [Related]
18. The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6.
Mankowski DC
Drug Metab Dispos; 1999 Sep; 27(9):1024-8. PubMed ID: 10460802
[TBL] [Abstract][Full Text] [Related]
19. Oxidation of quinidine by human liver cytochrome P-450.
Guengerich FP; Müller-Enoch D; Blair IA
Mol Pharmacol; 1986 Sep; 30(3):287-95. PubMed ID: 3748010
[TBL] [Abstract][Full Text] [Related]
20. (+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver.
Prueksaritanont T; Dwyer LM; Cribb AE
Biochem Pharmacol; 1995 Oct; 50(9):1521-5. PubMed ID: 7503805
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]