BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 7618347)

  • 1. Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.
    Jewell H; Maggs JL; Harrison AC; O'Neill PM; Ruscoe JE; Park BK
    Xenobiotica; 1995 Feb; 25(2):199-217. PubMed ID: 7618347
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.
    Ruscoe JE; Jewell H; Maggs JL; O'Neill PM; Storr RC; Ward SA; Park BK
    J Pharmacol Exp Ther; 1995 Apr; 273(1):393-404. PubMed ID: 7714794
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The mechanism of bioactivation and antigen formation of amodiaquine in the rat.
    Harrison AC; Kitteringham NR; Clarke JB; Park BK
    Biochem Pharmacol; 1992 Apr; 43(7):1421-30. PubMed ID: 1567466
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
    O'Neill PM; Mukhtar A; Stocks PA; Randle LE; Hindley S; Ward SA; Storr RC; Bickley JF; O'Neil IA; Maggs JL; Hughes RH; Winstanley PA; Bray PG; Park BK
    J Med Chem; 2003 Nov; 46(23):4933-45. PubMed ID: 14584944
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore.
    Williams DP; Antoine DJ; Butler PJ; Jones R; Randle L; Payne A; Howard M; Gardner I; Blagg J; Park BK
    J Pharmacol Exp Ther; 2007 Sep; 322(3):1208-20. PubMed ID: 17556636
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
    Teffera Y; Choquette D; Liu J; Colletti AE; Hollis LS; Lin MH; Zhao Z
    Chem Res Toxicol; 2010 Nov; 23(11):1743-52. PubMed ID: 20825217
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolism and bioactivation of clozapine by human liver in vitro.
    Pirmohamed M; Williams D; Madden S; Templeton E; Park BK
    J Pharmacol Exp Ther; 1995 Mar; 272(3):984-90. PubMed ID: 7891353
    [TBL] [Abstract][Full Text] [Related]  

  • 8. N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents.
    Ng SF; Waxman DJ
    Cancer Res; 1991 May; 51(9):2340-5. PubMed ID: 1707751
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine.
    Zhang Y; Vermeulen NP; Commandeur JN
    Br J Clin Pharmacol; 2017 Mar; 83(3):572-583. PubMed ID: 27718269
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.
    Hissink AM; Oudshoorn MJ; Van Ommen B; Haenen GR; Van Bladeren PJ
    Chem Res Toxicol; 1996 Dec; 9(8):1249-56. PubMed ID: 8951226
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.
    Hyland R; Gescher A; Thummel K; Schiller C; Jheeta P; Mynett K; Smith AW; Mráz J
    Mol Pharmacol; 1992 Feb; 41(2):259-66. PubMed ID: 1538706
    [TBL] [Abstract][Full Text] [Related]  

  • 13. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
    Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
    [TBL] [Abstract][Full Text] [Related]  

  • 14. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
    Beland FA
    Toxic Rep Ser; 1999 Aug; (59):1-66, A1-E7. PubMed ID: 11803702
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.
    Jurva U; Holmén A; Grönberg G; Masimirembwa C; Weidolf L
    Chem Res Toxicol; 2008 Apr; 21(4):928-35. PubMed ID: 18361508
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: chemical mechanisms and the effects of fluorine substitution.
    Tingle MD; Jewell H; Maggs JL; O'Neill PM; Park BK
    Biochem Pharmacol; 1995 Sep; 50(7):1113-9. PubMed ID: 7575670
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
    Tang C; Subramanian R; Kuo Y; Krymgold S; Lu P; Kuduk SD; Ng C; Feng DM; Elmore C; Soli E; Ho J; Bock MG; Baillie TA; Prueksaritanont T
    Chem Res Toxicol; 2005 Jun; 18(6):934-45. PubMed ID: 15962928
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.
    Naisbitt DJ; Ruscoe JE; Williams D; O'Neill PM; Pirmohamed M; Park BK
    J Pharmacol Exp Ther; 1997 Feb; 280(2):884-93. PubMed ID: 9023303
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effect of intestinal glucuronidation in limiting hepatic exposure and bioactivation of raloxifene in humans and rats.
    Dalvie D; Kang P; Zientek M; Xiang C; Zhou S; Obach RS
    Chem Res Toxicol; 2008 Dec; 21(12):2260-71. PubMed ID: 19548350
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
    Grillo MP; Ma J; Teffera Y; Waldon DJ
    Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.