174 related articles for article (PubMed ID: 7618347)
21. Cytochrome P450 inactivation during reductive metabolism of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) by phenobarbital- and pyridine-induced rat liver microsomes.
Ferrara R; Tolando R; King LJ; Manno M
Toxicol Appl Pharmacol; 1997 Apr; 143(2):420-8. PubMed ID: 9144458
[TBL] [Abstract][Full Text] [Related]
22. Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib.
Nardone-White DT; Bissada JE; Abouda AA; Jackson KD
Drug Metab Dispos; 2021 Mar; 49(3):233-244. PubMed ID: 33376146
[No Abstract] [Full Text] [Related]
23. alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver.
te Koppele JM; Dogterom P; Vermeulen NP; Meijer DK; van der Gen A; Mulder GJ
J Pharmacol Exp Ther; 1986 Dec; 239(3):905-14. PubMed ID: 3795049
[TBL] [Abstract][Full Text] [Related]
24. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
Tang W; Stearns RA; Wang RW; Chiu SH; Baillie TA
Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
[TBL] [Abstract][Full Text] [Related]
25. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
Wang YP; Yan J; Fu PP; Chou MW
Toxicol Lett; 2005 Mar; 155(3):411-20. PubMed ID: 15649625
[TBL] [Abstract][Full Text] [Related]
26. In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.
Sahali-Sahly Y; Balani SK; Lin JH; Baillie TA
Chem Res Toxicol; 1996 Sep; 9(6):1007-12. PubMed ID: 8870989
[TBL] [Abstract][Full Text] [Related]
27. Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase.
Ng SF; Waxman DJ
Cancer Res; 1990 Feb; 50(3):464-71. PubMed ID: 2105156
[TBL] [Abstract][Full Text] [Related]
28. Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity.
Zhang Y; den Braver-Sewradj SP; Vos JC; Vermeulen NPE; Commandeur JNM
Toxicol Lett; 2017 Jun; 275():83-91. PubMed ID: 28478157
[TBL] [Abstract][Full Text] [Related]
29. Amodiaquine-induced oxidative stress in a hepatocyte inflammation model.
Tafazoli S; O'Brien PJ
Toxicology; 2009 Feb; 256(1-2):101-9. PubMed ID: 19059302
[TBL] [Abstract][Full Text] [Related]
30. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.
Maggs JL; Williams D; Pirmohamed M; Park BK
J Pharmacol Exp Ther; 1995 Dec; 275(3):1463-75. PubMed ID: 8531117
[TBL] [Abstract][Full Text] [Related]
31. Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate.
Masubuchi Y; Igarashi S; Suzuki T; Horie T; Narimatsu S
J Pharmacol Exp Ther; 1996 Nov; 279(2):724-31. PubMed ID: 8930177
[TBL] [Abstract][Full Text] [Related]
32. Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry.
Alvarez-Diez TM; Zheng J
Drug Metab Dispos; 2004 Dec; 32(12):1345-50. PubMed ID: 15328249
[TBL] [Abstract][Full Text] [Related]
33. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
[TBL] [Abstract][Full Text] [Related]
34. Renal tumorigenicity of 1,1-dichloroethene in mice: the role of male-specific expression of cytochrome P450 2E1 in the renal bioactivation of 1,1-dichloroethene.
Speerschneider P; Dekant W
Toxicol Appl Pharmacol; 1995 Jan; 130(1):48-56. PubMed ID: 7839370
[TBL] [Abstract][Full Text] [Related]
35. Prediction of furan pharmacokinetics from hepatocyte studies: comparison of bioactivation and hepatic dosimetry in rats, mice, and humans.
Kedderis GL; Held SD
Toxicol Appl Pharmacol; 1996 Sep; 140(1):124-30. PubMed ID: 8806878
[TBL] [Abstract][Full Text] [Related]
36. Catalyzation of cocaine N-demethylation by cytochromes P4502B, P4503A, and P4502D in fish liver.
Arinç E; Bozcaarmutlu A
J Biochem Mol Toxicol; 2003; 17(3):169-76. PubMed ID: 12815613
[TBL] [Abstract][Full Text] [Related]
37. Identification of cytochrome P-450IIB1 as a cocaine-bioactivating isoform in rat hepatic microsomes and in cultured rat hepatocytes.
Boelsterli UA; Lanzotti A; Göldlin C; Oertle M
Drug Metab Dispos; 1992; 20(1):96-101. PubMed ID: 1347004
[TBL] [Abstract][Full Text] [Related]
38. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
Wen B; Ma L; Zhu M
Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
[TBL] [Abstract][Full Text] [Related]
39. Bioactivation of flutamide metabolites by human liver microsomes.
Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
[TBL] [Abstract][Full Text] [Related]
40. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
