BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 7622502)

  • 1. alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.
    Lomas DA; Elliott PR; Sidhar SK; Foreman RC; Finch JT; Cox DW; Whisstock JC; Carrell RW
    J Biol Chem; 1995 Jul; 270(28):16864-70. PubMed ID: 7622502
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization.
    Lomas DA; Finch JT; Seyama K; Nukiwa T; Carrell RW
    J Biol Chem; 1993 Jul; 268(21):15333-5. PubMed ID: 8340361
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants.
    Sidhar SK; Lomas DA; Carrell RW; Foreman RC
    J Biol Chem; 1995 Apr; 270(15):8393-6. PubMed ID: 7721731
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loop-sheet polymerization: the structural basis of Z alpha 1-antitrypsin accumulation in the liver.
    Lomas DA
    Clin Sci (Lond); 1994 May; 86(5):489-95. PubMed ID: 8033502
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Differential detection of PAS-positive inclusions formed by the Z, Siiyama, and Mmalton variants of alpha1-antitrypsin.
    Janciauskiene S; Eriksson S; Callea F; Mallya M; Zhou A; Seyama K; Hata S; Lomas DA
    Hepatology; 2004 Nov; 40(5):1203-10. PubMed ID: 15486938
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin.
    Lomas DA; Evans DL; Stone SR; Chang WS; Carrell RW
    Biochemistry; 1993 Jan; 32(2):500-8. PubMed ID: 8422359
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Conformational changes in serpins and the mechanism of alpha 1-antitrypsin deficiency.
    Carrell RW; Whisstock J; Lomas DA
    Am J Respir Crit Care Med; 1994 Dec; 150(6 Pt 2):S171-5. PubMed ID: 7952655
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency.
    Callea F; Giovannoni I; Francalanci P; Boldrini R; Faa G; Medicina D; Nobili V; Desmet VJ; Ishak K; Seyama K; Bellacchio E
    Orphanet J Rare Dis; 2018 May; 13(1):79. PubMed ID: 29769092
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Preparation and characterization of latent alpha 1-antitrypsin.
    Lomas DA; Elliott PR; Chang WS; Wardell MR; Carrell RW
    J Biol Chem; 1995 Mar; 270(10):5282-8. PubMed ID: 7890640
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.
    Mahadeva R; Dafforn TR; Carrell RW; Lomas DA
    J Biol Chem; 2002 Mar; 277(9):6771-4. PubMed ID: 11773044
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
    Lomas DA; Evans DL; Finch JT; Carrell RW
    Nature; 1992 Jun; 357(6379):605-7. PubMed ID: 1608473
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema.
    Elliott PR; Bilton D; Lomas DA
    Am J Respir Cell Mol Biol; 1998 May; 18(5):670-4. PubMed ID: 9569237
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Genetic variants of alpha1-antitrypsin.
    Salahuddin P
    Curr Protein Pept Sci; 2010 Mar; 11(2):101-17. PubMed ID: 19751191
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A protein structural approach to the solution of biological problems: alpha 1-antitrypsin as a recent example.
    Lomas DA; Carrell RW
    Am J Physiol; 1993 Sep; 265(3 Pt 1):L211-9. PubMed ID: 8214081
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular basis of the liver and lung disease associated with the alpha 1-antitrypsin deficiency allele Mmalton.
    Curiel DT; Holmes MD; Okayama H; Brantly ML; Vogelmeier C; Travis WD; Stier LE; Perks WH; Crystal RG
    J Biol Chem; 1989 Aug; 264(23):13938-45. PubMed ID: 2788166
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Defining the mechanism of polymerization in the serpinopathies.
    Ekeowa UI; Freeke J; Miranda E; Gooptu B; Bush MF; PĂ©rez J; Teckman J; Robinson CV; Lomas DA
    Proc Natl Acad Sci U S A; 2010 Oct; 107(40):17146-51. PubMed ID: 20855577
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations.
    Yamasaki M; Sendall TJ; Harris LE; Lewis GM; Huntington JA
    J Biol Chem; 2010 Oct; 285(40):30752-8. PubMed ID: 20667823
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A kinetic mechanism for the polymerization of alpha1-antitrypsin.
    Dafforn TR; Mahadeva R; Elliott PR; Sivasothy P; Lomas DA
    J Biol Chem; 1999 Apr; 274(14):9548-55. PubMed ID: 10092640
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
    Elliott PR; Lomas DA; Carrell RW; Abrahams JP
    Nat Struct Biol; 1996 Aug; 3(8):676-81. PubMed ID: 8756325
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A thermostable mutation located at the hydrophobic core of alpha 1-antitrypsin suppresses the folding defect of the Z-type variant.
    Kim J; Lee KN; Yi GS; Yu MH
    J Biol Chem; 1995 Apr; 270(15):8597-601. PubMed ID: 7721761
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.