361 related articles for article (PubMed ID: 7623765)
1. Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity.
Winn LM; Wells PG
Mol Pharmacol; 1995 Jul; 48(1):112-20. PubMed ID: 7623765
[TBL] [Abstract][Full Text] [Related]
2. Evidence for embryonic peroxidase-catalyzed bioactivation and glutathione-dependent cytoprotection in phenytoin teratogenicity: modulation by eicosatetraynoic acid and buthionine sulfoximine in murine embryo culture.
Miranda AF; Wiley MJ; Wells PG
Toxicol Appl Pharmacol; 1994 Feb; 124(2):230-41. PubMed ID: 8122268
[TBL] [Abstract][Full Text] [Related]
3. Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis.
Winn LM; Wells PG
Free Radic Biol Med; 1997; 22(4):607-21. PubMed ID: 9013124
[TBL] [Abstract][Full Text] [Related]
4. UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin.
Kim PM; Winn LM; Parman T; Wells PG
J Pharmacol Exp Ther; 1997 Jan; 280(1):200-9. PubMed ID: 8996197
[TBL] [Abstract][Full Text] [Related]
5. In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: potential molecular targets of chemical teratogenesis.
Liu L; Wells PG
Toxicol Appl Pharmacol; 1994 Apr; 125(2):247-55. PubMed ID: 8171432
[TBL] [Abstract][Full Text] [Related]
6. Potential molecular targets mediating chemical teratogenesis: in vitro peroxidase-catalyzed phenytoin metabolism and oxidative damage to proteins and lipids in murine maternal hepatic microsomes and embryonic 9000g supernatant.
Liu L; Wells PG
Toxicol Appl Pharmacol; 1995 Sep; 134(1):71-80. PubMed ID: 7676459
[TBL] [Abstract][Full Text] [Related]
7. Free radical scavenging enzymes in fetal dysmorphogenesis among offspring of diabetic rats.
Sivan E; Lee YC; Wu YK; Reece EA
Teratology; 1997 Dec; 56(6):343-9. PubMed ID: 9485543
[TBL] [Abstract][Full Text] [Related]
8. Phenytoin embryotoxicity: role of enzymatic bioactivation in a murine embryo culture model.
Shanks MJ; Wiley MJ; Kubow S; Wells PG
Teratology; 1989 Oct; 40(4):311-20. PubMed ID: 2814893
[TBL] [Abstract][Full Text] [Related]
9. Embryoprotective role of endogenous catalase in acatalasemic and human catalase-expressing mouse embryos exposed in culture to developmental and phenytoin-enhanced oxidative stress.
Abramov JP; Wells PG
Toxicol Sci; 2011 Apr; 120(2):428-38. PubMed ID: 21252394
[TBL] [Abstract][Full Text] [Related]
10. Role of reactive oxygen species (ROS) in the diabetes-induced anomalies in rat embryos in vitro: reduction in antioxidant enzymes and low-molecular-weight antioxidants (LMWA) may be the causative factor for increased anomalies.
Ornoy A; Zaken V; Kohen R
Teratology; 1999 Dec; 60(6):376-86. PubMed ID: 10590399
[TBL] [Abstract][Full Text] [Related]
11. Oxidative damage in chemical teratogenesis.
Wells PG; Kim PM; Laposa RR; Nicol CJ; Parman T; Winn LM
Mutat Res; 1997 Dec; 396(1-2):65-78. PubMed ID: 9434860
[TBL] [Abstract][Full Text] [Related]
12. DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues.
Liu L; Wells PG
Free Radic Biol Med; 1995 Nov; 19(5):639-48. PubMed ID: 8529923
[TBL] [Abstract][Full Text] [Related]
13. Embryonic catalase protects against endogenous and phenytoin-enhanced DNA oxidation and embryopathies in acatalasemic and human catalase-expressing mice.
Abramov JP; Wells PG
FASEB J; 2011 Jul; 25(7):2188-200. PubMed ID: 21478259
[TBL] [Abstract][Full Text] [Related]
14. Protection against reactive oxygen species during mouse preimplantation embryo development: role of EDTA, oxygen tension, catalase, superoxide dismutase and pyruvate.
Orsi NM; Leese HJ
Mol Reprod Dev; 2001 May; 59(1):44-53. PubMed ID: 11335946
[TBL] [Abstract][Full Text] [Related]
15. Embryonic catalase protects against ethanol embryopathies in acatalasemic mice and transgenic human catalase-expressing mice in embryo culture.
Miller-Pinsler L; Wells PG
Toxicol Appl Pharmacol; 2015 Sep; 287(3):232-9. PubMed ID: 26074427
[TBL] [Abstract][Full Text] [Related]
16. Increased susceptibility to phenytoin teratogenicity: excessive generation of reactive oxygen species or impaired antioxidant defense?
Azarbayjani F; Borg LA; Danielsson BR
Basic Clin Pharmacol Toxicol; 2006 Oct; 99(4):305-11. PubMed ID: 17040216
[TBL] [Abstract][Full Text] [Related]
17. Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions.
Weksler-Zangen S; Yaffe P; Ornoy A
Birth Defects Res A Clin Mol Teratol; 2003 Jun; 67(6):429-37. PubMed ID: 12962287
[TBL] [Abstract][Full Text] [Related]
18. Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: studies on cultured rat embryos.
Ornoy A; Rand SB; Bischitz N
Birth Defects Res B Dev Reprod Toxicol; 2010 Apr; 89(2):106-15. PubMed ID: 20127827
[TBL] [Abstract][Full Text] [Related]
19. Variable in vivo embryoprotective role for ataxia-telangiectasia-mutated against constitutive and phenytoin-enhanced oxidative stress in atm knockout mice.
Bhuller Y; Jeng W; Wells PG
Toxicol Sci; 2006 Sep; 93(1):146-55. PubMed ID: 16714389
[TBL] [Abstract][Full Text] [Related]
20. 8-Iso-PGF(2alpha) administration generates dysmorphogenesis and increased lipid peroxidation in rat embryos in vitro.
Wentzel P; Eriksson UJ
Teratology; 2002 Oct; 66(4):164-8. PubMed ID: 12353212
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
