556 related articles for article (PubMed ID: 7623840)
1. The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
Wek SA; Zhu S; Wek RC
Mol Cell Biol; 1995 Aug; 15(8):4497-506. PubMed ID: 7623840
[TBL] [Abstract][Full Text] [Related]
2. Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.
Ramirez M; Wek RC; Vazquez de Aldana CR; Jackson BM; Freeman B; Hinnebusch AG
Mol Cell Biol; 1992 Dec; 12(12):5801-15. PubMed ID: 1448107
[TBL] [Abstract][Full Text] [Related]
3. Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.
Zhu S; Sobolev AY; Wek RC
J Biol Chem; 1996 Oct; 271(40):24989-94. PubMed ID: 8798780
[TBL] [Abstract][Full Text] [Related]
4. GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.
Marton MJ; Crouch D; Hinnebusch AG
Mol Cell Biol; 1993 Jun; 13(6):3541-56. PubMed ID: 8497269
[TBL] [Abstract][Full Text] [Related]
5. Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.
Wek RC; Jackson BM; Hinnebusch AG
Proc Natl Acad Sci U S A; 1989 Jun; 86(12):4579-83. PubMed ID: 2660141
[TBL] [Abstract][Full Text] [Related]
6. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.
Sood R; Porter AC; Olsen DA; Cavener DR; Wek RC
Genetics; 2000 Feb; 154(2):787-801. PubMed ID: 10655230
[TBL] [Abstract][Full Text] [Related]
7. Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA.
Vazquez de Aldana CR; Wek RC; Segundo PS; Truesdell AG; Hinnebusch AG
Mol Cell Biol; 1994 Dec; 14(12):7920-32. PubMed ID: 7969132
[TBL] [Abstract][Full Text] [Related]
8. Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.
Yang R; Wek SA; Wek RC
Mol Cell Biol; 2000 Apr; 20(8):2706-17. PubMed ID: 10733573
[TBL] [Abstract][Full Text] [Related]
9. Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.
Wek RC; Ramirez M; Jackson BM; Hinnebusch AG
Mol Cell Biol; 1990 Jun; 10(6):2820-31. PubMed ID: 2188100
[TBL] [Abstract][Full Text] [Related]
10. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.
Marton MJ; Vazquez de Aldana CR; Qiu H; Chakraburtty K; Hinnebusch AG
Mol Cell Biol; 1997 Aug; 17(8):4474-89. PubMed ID: 9234705
[TBL] [Abstract][Full Text] [Related]
11. Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.
Zhu S; Wek RC
J Biol Chem; 1998 Jan; 273(3):1808-14. PubMed ID: 9430731
[TBL] [Abstract][Full Text] [Related]
12. Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.
Kubota H; Obata T; Ota K; Sasaki T; Ito T
J Biol Chem; 2003 Jun; 278(23):20457-60. PubMed ID: 12676950
[TBL] [Abstract][Full Text] [Related]
13. Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.
Garcia-Barrio M; Dong J; Cherkasova VA; Zhang X; Zhang F; Ufano S; Lai R; Qin J; Hinnebusch AG
J Biol Chem; 2002 Aug; 277(34):30675-83. PubMed ID: 12070158
[TBL] [Abstract][Full Text] [Related]
14. cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control.
Sattlegger E; Hinnebusch AG; Barthelmess IB
J Biol Chem; 1998 Aug; 273(32):20404-16. PubMed ID: 9685394
[TBL] [Abstract][Full Text] [Related]
15. Differential requirements for P stalk components in activating yeast protein kinase Gcn2 by stalled ribosomes during stress.
Gupta R; Hinnebusch AG
Proc Natl Acad Sci U S A; 2023 Apr; 120(16):e2300521120. PubMed ID: 37043534
[TBL] [Abstract][Full Text] [Related]
16. Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.
Rolfes RJ; Hinnebusch AG
Mol Cell Biol; 1993 Aug; 13(8):5099-111. PubMed ID: 8336737
[TBL] [Abstract][Full Text] [Related]
17. Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae.
Feng L; Yoon H; Donahue TF
Mol Cell Biol; 1994 Aug; 14(8):5139-53. PubMed ID: 8035796
[TBL] [Abstract][Full Text] [Related]
18. Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain.
Dong J; Qiu H; Garcia-Barrio M; Anderson J; Hinnebusch AG
Mol Cell; 2000 Aug; 6(2):269-79. PubMed ID: 10983975
[TBL] [Abstract][Full Text] [Related]
19. Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.
Lageix S; Zhang J; Rothenburg S; Hinnebusch AG
PLoS Genet; 2015 Feb; 11(2):e1004991. PubMed ID: 25695491
[TBL] [Abstract][Full Text] [Related]
20. Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions.
Narasimhan J; Staschke KA; Wek RC
J Biol Chem; 2004 May; 279(22):22820-32. PubMed ID: 15010461
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]