170 related articles for article (PubMed ID: 7649979)
1. Fasciculin 2 binds to the peripheral site on acetylcholinesterase and inhibits substrate hydrolysis by slowing a step involving proton transfer during enzyme acylation.
Eastman J; Wilson EJ; Cerveñansky C; Rosenberry TL
J Biol Chem; 1995 Aug; 270(34):19694-701. PubMed ID: 7649979
[TBL] [Abstract][Full Text] [Related]
2. Binding of the neurotoxin fasciculin 2 to the acetylcholinesterase peripheral site drastically reduces the association and dissociation rate constants for N-methylacridinium binding to the active site.
Rosenberry TL; Rabl CR; Neumann E
Biochemistry; 1996 Jan; 35(3):685-90. PubMed ID: 8547248
[TBL] [Abstract][Full Text] [Related]
3. Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect.
Szegletes T; Mallender WD; Thomas PJ; Rosenberry TL
Biochemistry; 1999 Jan; 38(1):122-33. PubMed ID: 9890890
[TBL] [Abstract][Full Text] [Related]
4. A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate.
Rosenberry TL; Mallender WD; Thomas PJ; Szegletes T
Chem Biol Interact; 1999 May; 119-120():85-97. PubMed ID: 10421442
[TBL] [Abstract][Full Text] [Related]
5. Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway.
Mallender WD; Szegletes T; Rosenberry TL
Biochemistry; 2000 Jul; 39(26):7753-63. PubMed ID: 10869180
[TBL] [Abstract][Full Text] [Related]
6. Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate.
Johnson JL; Cusack B; Davies MP; Fauq A; Rosenberry TL
Biochemistry; 2003 May; 42(18):5438-52. PubMed ID: 12731886
[TBL] [Abstract][Full Text] [Related]
7. Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands.
Szegletes T; Mallender WD; Rosenberry TL
Biochemistry; 1998 Mar; 37(12):4206-16. PubMed ID: 9521743
[TBL] [Abstract][Full Text] [Related]
8. Allosteric control of acetylcholinesterase catalysis by fasciculin.
Radić Z; Quinn DM; Vellom DC; Camp S; Taylor P
J Biol Chem; 1995 Sep; 270(35):20391-9. PubMed ID: 7657613
[TBL] [Abstract][Full Text] [Related]
9. Molecular basis of inhibition of substrate hydrolysis by a ligand bound to the peripheral site of acetylcholinesterase.
Auletta JT; Johnson JL; Rosenberry TL
Chem Biol Interact; 2010 Sep; 187(1-3):135-41. PubMed ID: 20493829
[TBL] [Abstract][Full Text] [Related]
10. Site of fasciculin interaction with acetylcholinesterase.
Radić Z; Duran R; Vellom DC; Li Y; Cervenansky C; Taylor P
J Biol Chem; 1994 Apr; 269(15):11233-9. PubMed ID: 8157652
[TBL] [Abstract][Full Text] [Related]
11. Organophosphorylation of acetylcholinesterase in the presence of peripheral site ligands. Distinct effects of propidium and fasciculin.
Mallender WD; Szegletes T; Rosenberry TL
J Biol Chem; 1999 Mar; 274(13):8491-9. PubMed ID: 10085081
[TBL] [Abstract][Full Text] [Related]
12. Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site.
Beri V; Auletta JT; Maharvi GM; Wood JF; Fauq AH; Rosenberry TL
Chem Biol Interact; 2013 Mar; 203(1):38-43. PubMed ID: 23047027
[TBL] [Abstract][Full Text] [Related]
13. Mechanism of acetylcholinesterase inhibition by fasciculin: a 5-ns molecular dynamics simulation.
Tai K; Shen T; Henchman RH; Bourne Y; Marchot P; McCammon JA
J Am Chem Soc; 2002 May; 124(21):6153-61. PubMed ID: 12022850
[TBL] [Abstract][Full Text] [Related]
14. Allosteric control of acetylcholinesterase activity by monoclonal antibodies.
Saxena A; Hur R; Doctor BP
Biochemistry; 1998 Jan; 37(1):145-54. PubMed ID: 9425034
[TBL] [Abstract][Full Text] [Related]
15. Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin.
Radić Z; Kirchhoff PD; Quinn DM; McCammon JA; Taylor P
J Biol Chem; 1997 Sep; 272(37):23265-77. PubMed ID: 9287336
[TBL] [Abstract][Full Text] [Related]
16. [The fasciculin-acetylcholinesterase interaction].
Marchot P
J Soc Biol; 1999; 193(6):505-8. PubMed ID: 10783708
[TBL] [Abstract][Full Text] [Related]
17. Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.
Ordentlich A; Barak D; Kronman C; Flashner Y; Leitner M; Segall Y; Ariel N; Cohen S; Velan B; Shafferman A
J Biol Chem; 1993 Aug; 268(23):17083-95. PubMed ID: 8349597
[TBL] [Abstract][Full Text] [Related]
18. Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites.
De Ferrari GV; Mallender WD; Inestrosa NC; Rosenberry TL
J Biol Chem; 2001 Jun; 276(26):23282-7. PubMed ID: 11313335
[TBL] [Abstract][Full Text] [Related]
19. Interaction kinetics of reversible inhibitors and substrates with acetylcholinesterase and its fasciculin 2 complex.
Radić Z; Taylor P
J Biol Chem; 2001 Feb; 276(7):4622-33. PubMed ID: 11036076
[TBL] [Abstract][Full Text] [Related]
20. Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter.
Rosenberry TL; Sonoda LK; Dekat SE; Cusack B; Johnson JL
Biochemistry; 2008 Dec; 47(49):13056-63. PubMed ID: 19006330
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
