BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 7669049)

  • 1. CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.
    McGuire TF; Qian Y; Blaskovich MA; Fossum RD; Sun J; Marlowe T; Corey SJ; Wathen SP; Vogt A; Hamilton AD
    Biochem Biophys Res Commun; 1995 Sep; 214(1):295-303. PubMed ID: 7669049
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
    Lerner EC; Qian Y; Blaskovich MA; Fossum RD; Vogt A; Sun J; Cox AD; Der CJ; Hamilton AD; Sebti SM
    J Biol Chem; 1995 Nov; 270(45):26802-6. PubMed ID: 7592920
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
    McGuire TF; Qian Y; Vogt A; Hamilton AD; Sebti SM
    J Biol Chem; 1996 Nov; 271(44):27402-7. PubMed ID: 8910319
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.
    Vogt A; Qian Y; Blaskovich MA; Fossum RD; Hamilton AD; Sebti SM
    J Biol Chem; 1995 Jan; 270(2):660-4. PubMed ID: 7822292
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
    Lerner EC; Qian Y; Hamilton AD; Sebti SM
    J Biol Chem; 1995 Nov; 270(45):26770-3. PubMed ID: 7592913
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells.
    Carloni V; Pinzani M; Giusti S; Romanelli RG; Parola M; Bellomo G; Failli P; Hamilton AD; Sebti SM; Laffi G; Gentilini P
    Hepatology; 2000 Jan; 31(1):131-40. PubMed ID: 10613738
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.
    Yu JC; Gutkind JS; Mahadevan D; Li W; Meyers KA; Pierce JH; Heidaran MA
    J Cell Biol; 1994 Oct; 127(2):479-87. PubMed ID: 7929590
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor.
    McGuire TF; Corey SJ; Sebti SM
    J Biol Chem; 1993 Oct; 268(30):22227-30. PubMed ID: 7693661
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes.
    Roche S; Dhand R; Waterfield MD; Courtneidge SA
    Biochem J; 1994 Aug; 301 ( Pt 3)(Pt 3):703-11. PubMed ID: 7519847
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
    Sun J; Qian Y; Hamilton AD; Sebti SM
    Cancer Res; 1995 Oct; 55(19):4243-7. PubMed ID: 7671229
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
    Sun J; Blaskovich MA; Knowles D; Qian Y; Ohkanda J; Bailey RD; Hamilton AD; Sebti SM
    Cancer Res; 1999 Oct; 59(19):4919-26. PubMed ID: 10519405
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway.
    Law BK; Nørgaard P; Gnudi L; Kahn BB; Poulson HS; Moses HL
    J Biol Chem; 1999 Feb; 274(8):4743-8. PubMed ID: 9988711
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells.
    Marra F; Pinzani M; DeFranco R; Laffi G; Gentilini P
    FEBS Lett; 1995 Dec; 376(3):141-5. PubMed ID: 7498528
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma.
    Olivera A; Edsall L; Poulton S; Kazlauskas A; Spiegel S
    FASEB J; 1999 Sep; 13(12):1593-600. PubMed ID: 10463951
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP.
    Bazenet CE; Kazlauskas A
    Oncogene; 1994 Feb; 9(2):517-25. PubMed ID: 8290262
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC; Zhang TT; Knowles DB; Qian Y; Hamilton AD; Sebti SM
    Oncogene; 1997 Sep; 15(11):1283-8. PubMed ID: 9315095
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF.
    Lopez-Ilasaca M; Li W; Uren A; Yu JC; Kazlauskas A; Gutkind JS; Heidaran MA
    Biochem Biophys Res Commun; 1997 Mar; 232(2):273-7. PubMed ID: 9125162
    [TBL] [Abstract][Full Text] [Related]  

  • 18. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.
    Chung J; Grammer TC; Lemon KP; Kazlauskas A; Blenis J
    Nature; 1994 Jul; 370(6484):71-5. PubMed ID: 8015612
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cell adhesion regulates platelet-derived growth factor-induced MAP kinase and PI-3 kinase activation in stellate cells.
    Carloni V; Defranco RM; Caligiuri A; Gentilini A; Sciammetta SC; Baldi E; Lottini B; Gentilini P; Pinzani M
    Hepatology; 2002 Sep; 36(3):582-91. PubMed ID: 12198650
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
    Sun J; Qian Y; Hamilton AD; Sebti SM
    Oncogene; 1998 Mar; 16(11):1467-73. PubMed ID: 9525745
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.