BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

151 related articles for article (PubMed ID: 7679576)

  • 1. Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditions.
    Cahill A; Jenkins TC; White IN
    Biochem Pharmacol; 1993 Jan; 45(2):321-9. PubMed ID: 7679576
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
    Riley RJ; Workman P
    Biochem Pharmacol; 1992 Jan; 43(2):167-74. PubMed ID: 1739405
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines.
    Cahill A; White IN
    Carcinogenesis; 1990 Aug; 11(8):1407-11. PubMed ID: 2117504
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
    Walton MI; Workman P
    Biochem Pharmacol; 1990 Jun; 39(11):1735-42. PubMed ID: 2344370
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J; Oleschuk CJ; Guziec F; Guziec L; Fiterman DJ; Monterrosa C; Begleiter A
    Cancer Chemother Pharmacol; 2002 Feb; 49(2):101-10. PubMed ID: 11862423
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
    Walton MI; Sugget N; Workman P
    Int J Radiat Oncol Biol Phys; 1992; 22(4):643-7. PubMed ID: 1544831
    [TBL] [Abstract][Full Text] [Related]  

  • 7. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.
    Plumb JA; Gerritsen M; Workman P
    Br J Cancer; 1994 Dec; 70(6):1136-43. PubMed ID: 7526885
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
    Riley RJ; Hemingway SA; Graham MA; Workman P
    Biochem Pharmacol; 1993 Mar; 45(5):1065-77. PubMed ID: 8461036
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity.
    Elwell JH; Siim BG; Evans JW; Brown JM
    Biochem Pharmacol; 1997 Jul; 54(2):249-57. PubMed ID: 9271329
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Genotoxic effects of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions.
    Cahill A; Jenkins TC; Pickering P; White IN
    Chem Biol Interact; 1995 Mar; 95(1-2):97-107. PubMed ID: 7697757
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.
    Plumb JA; Workman P
    Int J Cancer; 1994 Jan; 56(1):134-9. PubMed ID: 8262670
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.
    Siegel D; Gibson NW; Preusch PC; Ross D
    Cancer Res; 1990 Nov; 50(22):7293-300. PubMed ID: 2121335
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
    Siegel D; Gibson NW; Preusch PC; Ross D
    Cancer Res; 1990 Dec; 50(23):7483-9. PubMed ID: 1701346
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
    Walton MI; Smith PJ; Workman P
    Cancer Commun; 1991 Jul; 3(7):199-206. PubMed ID: 1714284
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).
    Patterson AV; Robertson N; Houlbrook S; Stephens MA; Adams GE; Harris AL; Stratford IJ; Carmichael J
    Int J Radiat Oncol Biol Phys; 1994 May; 29(2):369-72. PubMed ID: 8195035
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia.
    Begleiter A; Robotham E; Leith MK
    Mol Pharmacol; 1992 Apr; 41(4):677-82. PubMed ID: 1373799
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.
    Khan S; O'Brien PJ
    Br J Cancer; 1995 Apr; 71(4):780-5. PubMed ID: 7710944
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Influence of DT diaphorase on quinone-mediated genotoxicity in human and fish cell lines.
    Hasspieler BM; Haffner GD; Adeli K
    Mutat Res; 1996 May; 360(1):43-9. PubMed ID: 8657209
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies.
    Wang J; Biedermann KA; Wolf CR; Brown JM
    Br J Cancer; 1993 Feb; 67(2):321-5. PubMed ID: 8431360
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
    Plumb JA; Gerritsen M; Milroy R; Thomson P; Workman P
    Int J Radiat Oncol Biol Phys; 1994 May; 29(2):295-9. PubMed ID: 8195022
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.