BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 7682567)

  • 1. Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates.
    Chung KN; Saikawa Y; Paik TH; Dixon KH; Mulligan T; Cowan KH; Elwood PC
    J Clin Invest; 1993 Apr; 91(4):1289-94. PubMed ID: 7682567
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rapid turnover and impaired cell-surface expression of the human folate receptor in mouse L(tk-) fibroblasts, a cell line defective in glycosylphosphatidylinositol tail synthesis.
    Chung KN; Roberts S; Kim CH; Kirassova M; Trepel J; Elwood PC
    Arch Biochem Biophys; 1995 Sep; 322(1):228-34. PubMed ID: 7574680
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
    Westerhof GR; Rijnboutt S; Schornagel JH; Pinedo HM; Peters GJ; Jansen G
    Cancer Res; 1995 Sep; 55(17):3795-802. PubMed ID: 7641196
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance.
    Jansen G; Westerhof GR; Kathmann I; Rademaker BC; Rijksen G; Schornagel JH
    Cancer Res; 1989 May; 49(9):2455-9. PubMed ID: 2706633
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Decreased expression of the human folate receptor mediates transport-defective methotrexate resistance in KB cells.
    Saikawa Y; Knight CB; Saikawa T; Page ST; Chabner BA; Elwood PC
    J Biol Chem; 1993 Mar; 268(7):5293-301. PubMed ID: 7680349
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of membrane-associated folate binding protein in the cytotoxicity of antifolates in KB, IGROV1, and L1210A cells.
    Schultz RM; Andis SL; Shackelford KA; Gates SB; Ratnam M; Mendelsohn LG; Shih C; Grindey GB
    Oncol Res; 1995; 7(2):97-102. PubMed ID: 7579732
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.
    Jansen G; Barr H; Kathmann I; Bunni MA; Priest DG; Noordhuis P; Peters GJ; Assaraf YG
    Mol Pharmacol; 1999 Apr; 55(4):761-9. PubMed ID: 10101035
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate.
    Pinard MF; Jolivet J; Ratnam M; Kathmann I; Molthoff C; Westerhof R; Schornagel JH; Jansen G
    Cancer Chemother Pharmacol; 1996; 38(3):281-8. PubMed ID: 8646804
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells.
    Moscow JA; Gong M; He R; Sgagias MK; Dixon KH; Anzick SL; Meltzer PS; Cowan KH
    Cancer Res; 1995 Sep; 55(17):3790-4. PubMed ID: 7641195
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Site-directed mutagenesis of tryptophan residues to conserved hydrophobic residues inhibits the processing of human KB cell folate receptor.
    Chung KN; Paik TH; Roberts S; Kim CH; Kirassova M; Weinstein JN; Trepel JB; Elwood PC
    Arch Biochem Biophys; 1994 Dec; 315(2):407-14. PubMed ID: 7986085
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Folate-binding protein mRNA is decreased in methotrexate-resistant KB cells.
    Hsueh CT; Dolnick BJ
    Oncol Res; 1992; 4(11-12):497-505. PubMed ID: 1299378
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure.
    Elwood PC; Nachmanoff K; Saikawa Y; Page ST; Pacheco P; Roberts S; Chung KN
    Biochemistry; 1997 Feb; 36(6):1467-78. PubMed ID: 9063895
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients.
    van der Heijden JW; Oerlemans R; Dijkmans BA; Qi H; van der Laken CJ; Lems WF; Jackman AL; Kraan MC; Tak PP; Ratnam M; Jansen G
    Arthritis Rheum; 2009 Jan; 60(1):12-21. PubMed ID: 19116913
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
    Zhao R; Gao F; Babani S; Goldman ID
    Clin Cancer Res; 2000 Aug; 6(8):3304-11. PubMed ID: 10955817
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Contrasting effects of oncogene expression on two carrier-mediated systems internalizing folate compounds in Fisher rat 3T3 cells.
    Kühnel JM; Chiao JH; Sirotnak FM
    J Cell Physiol; 2000 Sep; 184(3):364-72. PubMed ID: 10911368
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Peters GJ; Smitskamp-Wilms E; Smid K; Pinedo HM; Jansen G
    Cancer Res; 1999 Nov; 59(21):5529-35. PubMed ID: 10554030
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
    Wang Y; Zhao R; Goldman ID
    Clin Cancer Res; 2004 Sep; 10(18 Pt 1):6256-64. PubMed ID: 15448015
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Membrane transport of methotrexate in a squamous carcinoma cell line adapted to low folate concentrations.
    van der Laan BF; Jansen G; van Gestel JA; Schornagel JH; Hordijk GJ
    Anticancer Res; 1991; 11(3):1265-8. PubMed ID: 1888158
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
    McGuire JJ; Bergoltz VV; Heitzman KJ; Haile WH; Russell CA; Bolanowska WE; Kotake Y; Haneda T; Nomura H
    Cancer Res; 1994 May; 54(10):2673-9. PubMed ID: 8168096
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates.
    Sierra EE; Goldman ID
    Semin Oncol; 1999 Apr; 26(2 Suppl 6):11-23. PubMed ID: 10598550
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.