BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

102 related articles for article (PubMed ID: 7683054)

  • 1. Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogues.
    Hoffman JM; Smith AM; Rooney CS; Fisher TE; Wai JS; Thomas CM; Bamberger DL; Barnes JL; Williams TM; Jones JH
    J Med Chem; 1993 Apr; 36(8):953-66. PubMed ID: 7683054
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.
    Saari WS; Wai JS; Fisher TE; Thomas CM; Hoffman JM; Rooney CS; Smith AM; Jones JH; Bamberger DL; Goldman ME
    J Med Chem; 1992 Oct; 35(21):3792-802. PubMed ID: 1279173
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues.
    Hoffman JM; Wai JS; Thomas CM; Levin RB; O'Brien JA; Goldman ME
    J Med Chem; 1992 Oct; 35(21):3784-91. PubMed ID: 1279172
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one.
    Wai JS; Williams TM; Bamberger DL; Fisher TE; Hoffman JM; Hudcosky RJ; MacTough SC; Rooney CS; Saari WS; Thomas CM
    J Med Chem; 1993 Jan; 36(2):249-55. PubMed ID: 7678654
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.
    Goldman ME; Nunberg JH; O'Brien JA; Quintero JC; Schleif WA; Freund KF; Gaul SL; Saari WS; Wai JS; Hoffman JM
    Proc Natl Acad Sci U S A; 1991 Aug; 88(15):6863-7. PubMed ID: 1713693
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of HIV-1 reverse transcriptase by pyridinone derivatives. Potency, binding characteristics, and effect of template sequence.
    Carroll SS; Olsen DB; Bennett CD; Gotlib L; Graham DJ; Condra JH; Stern AM; Shafer JA; Kuo LC
    J Biol Chem; 1993 Jan; 268(1):276-81. PubMed ID: 7677997
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors.
    Goldman ME; O'Brien JA; Ruffing TL; Schleif WA; Sardana VV; Byrnes VW; Condra JH; Hoffman JM; Emini EA
    Antimicrob Agents Chemother; 1993 May; 37(5):947-9. PubMed ID: 7685996
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Metabolism of a new HIV-1 reverse transcriptase inhibitor, 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (L-696,229), in rat and liver slices.
    Balani SK; Pitzenberger SM; Kauffman LR; Arison BH; Ramjit HG; Goldman ME; O'Brien JA; King JD; Hoffman JM; Rooney CS
    Drug Metab Dispos; 1992; 20(6):869-76. PubMed ID: 1283569
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.
    Dollé V; Fan E; Nguyen CH; Aubertin AM; Kirn A; Andreola ML; Jamieson G; Tarrago-Litvak L; Bisagni E
    J Med Chem; 1995 Nov; 38(23):4679-86. PubMed ID: 7473595
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
    Dollé V; Nguyen CH; Legraverend M; Aubertin AM; Kirn A; Andreola ML; Ventura M; Tarrago-Litvak L; Bisagni E
    J Med Chem; 2000 Oct; 43(21):3949-62. PubMed ID: 11052800
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans.
    Balani SK; Kauffman LR; Arison BH; Olah TV; Goldman ME; Varga SL; O'Brien JA; Ramjit HG; Rooney CS; Hoffman JM
    Drug Metab Dispos; 1994; 22(2):200-5. PubMed ID: 7516852
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of template secondary structure on the inhibition of HIV-1 reverse transcriptase by a pyridinone non-nucleoside inhibitor.
    Olsen DB; Carroll SS; Culberson JC; Shafer JA; Kuo LC
    Nucleic Acids Res; 1994 Apr; 22(8):1437-43. PubMed ID: 7514786
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) with high potency against NNRTI-resistant HIV-1 strains.
    Li A; Ouyang Y; Wang Z; Cao Y; Liu X; Ran L; Li C; Li L; Zhang L; Qiao K; Xu W; Huang Y; Zhang Z; Tian C; Liu Z; Jiang S; Shao Y; Du Y; Ma L; Wang X; Liu J
    J Med Chem; 2013 May; 56(9):3593-608. PubMed ID: 23540737
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New pyridinone derivatives as potent HIV-1 nonnucleoside reverse transcriptase inhibitors.
    Le Van K; Cauvin C; de Walque S; Georges B; Boland S; Martinelli V; Demonté D; Durant F; Hevesi L; Van Lint C
    J Med Chem; 2009 Jun; 52(12):3636-43. PubMed ID: 19469474
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Flexible docking of pyridinone derivatives into the non-nucleoside inhibitor binding site of HIV-1 reverse transcriptase.
    Medina-Franco JL; Rodríguez-Morales S; Juárez-Gordiano C; Hernández-Campos A; Jiménez-Barbero J; Castillo R
    Bioorg Med Chem; 2004 Dec; 12(23):6085-95. PubMed ID: 15519154
    [TBL] [Abstract][Full Text] [Related]  

  • 16. L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro.
    Goldman ME; O'Brien JA; Ruffing TL; Nunberg JH; Schleif WA; Quintero JC; Siegl PK; Hoffman JM; Smith AM; Emini EA
    Antimicrob Agents Chemother; 1992 May; 36(5):1019-23. PubMed ID: 1380788
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Quantitative structure-activity relationship studies on some anti-human-immunodeficiency-virus-1 (anti-HIV-1) drugs: viral reverse transcriptase inhibitors.
    Garg R; Gupta SP
    J Enzyme Inhib; 1997 Apr; 12(1):1-12. PubMed ID: 9204378
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs.
    Cao Y; Zhang Y; Wu S; Yang Q; Sun X; Zhao J; Pei F; Guo Y; Tian C; Zhang Z; Wang H; Ma L; Liu J; Wang X
    Bioorg Med Chem; 2015 Jan; 23(1):149-59. PubMed ID: 25468035
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Difluoromethylbenzoxazole pyrimidine thioether derivatives: a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
    Boyer J; Arnoult E; Médebielle M; Guillemont J; Unge J; Jochmans D
    J Med Chem; 2011 Dec; 54(23):7974-85. PubMed ID: 22017513
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives.
    Barral K; Balzarini J; Neyts J; De Clercq E; Hider RC; Camplo M
    J Med Chem; 2006 Jan; 49(1):43-50. PubMed ID: 16392791
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.