118 related articles for article (PubMed ID: 7699709)
1. Tryptophan-derived NK1 antagonists: conformationally constrained heterocyclic bioisosteres of the ester linkage.
Lewis RT; Macleod AM; Merchant KJ; Kelleher F; Sanderson I; Herbert RH; Cascieri MA; Sadowski S; Ball RG; Hoogsteen K
J Med Chem; 1995 Mar; 38(6):923-33. PubMed ID: 7699709
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
MacLeod AM; Cascieri MA; Merchant KJ; Sadowski S; Hardwicke S; Lewis RT; MacIntyre DE; Metzger JM; Fong TM; Shepheard S
J Med Chem; 1995 Mar; 38(6):934-41. PubMed ID: 7535362
[TBL] [Abstract][Full Text] [Related]
3. Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.
MacLeod AM; Merchant KJ; Brookfield F; Kelleher F; Stevenson G; Owens AP; Swain CJ; Casiceri MA; Sadowski S; Ber E
J Med Chem; 1994 Apr; 37(9):1269-74. PubMed ID: 7513763
[TBL] [Abstract][Full Text] [Related]
4. Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.
Cascieri MA; Macleod AM; Underwood D; Shiao LL; Ber E; Sadowski S; Yu H; Merchant KJ; Swain CJ; Strader CD
J Biol Chem; 1994 Mar; 269(9):6587-91. PubMed ID: 7509807
[TBL] [Abstract][Full Text] [Related]
5. Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.
Di Fabio R; Alvaro G; Braggio S; Carletti R; Gerrard PA; Griffante C; Marchioro C; Pozzan A; Melotto S; Poffe A; Piccoli L; Ratti E; Tranquillini E; Trower M; Spada S; Corsi M
Bioorg Med Chem; 2013 Nov; 21(21):6264-73. PubMed ID: 24075145
[TBL] [Abstract][Full Text] [Related]
6. Discovery of orally bioavailable NK1 receptor antagonists.
Genicot C; Christophe B; Collart P; Gillard M; Goossens L; Hénichart JP; Lassoie MA; Moureau F; Neuwels M; Nicolas JM; Pasau P; Quéré L; Ryckmans T; Stiernet F; Taverne T; Van Keulen BJ
Bioorg Med Chem Lett; 2003 Feb; 13(3):437-42. PubMed ID: 12565946
[TBL] [Abstract][Full Text] [Related]
7. Potent NK1 receptor antagonists: synthesis and antagonistic activity of various heterocycles with an N-[3,5-bis(trifluoromethyl)benzyl]-N-methylcarbamoyl substituent.
Ikeura Y; Tanaka T; Kiyota Y; Morimoto S; Ogino M; Ishimaru T; Kamo I; Doi T; Natsugari H
Chem Pharm Bull (Tokyo); 1997 Oct; 45(10):1642-52. PubMed ID: 9353892
[TBL] [Abstract][Full Text] [Related]
8. Characterization of the binding and activity of a high affinity, pseudoirreversible morpholino tachykinin NK1 receptor antagonist.
Cascieri MA; Ber E; Fong TM; Hale JJ; Tang F; Shiao LL; Mills SG; MacCoss M; Sadowski S; Tota MR; Strader CD
Eur J Pharmacol; 1997 May; 325(2-3):253-61. PubMed ID: 9163573
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and NK1/NK2 receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazines.
Ting PC; Lee JF; Anthes JC; Shih NY; Piwinski JJ
Bioorg Med Chem Lett; 2000 Oct; 10(20):2333-5. PubMed ID: 11055350
[TBL] [Abstract][Full Text] [Related]
10. Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate.
Di Fabio R; Alvaro G; Griffante C; Pizzi DA; Donati D; Mattioli M; Cimarosti Z; Guercio G; Marchioro C; Provera S; Zonzini L; Montanari D; Melotto S; Gerrard PA; Trist DG; Ratti E; Corsi M
J Med Chem; 2011 Feb; 54(4):1071-9. PubMed ID: 21229983
[TBL] [Abstract][Full Text] [Related]
11. N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.
MacLeod AM; Merchant KJ; Cascieri MA; Sadowski S; Ber E; Swain CJ; Baker R
J Med Chem; 1993 Jul; 36(14):2044-5. PubMed ID: 8393115
[No Abstract] [Full Text] [Related]
12. Cyclic urea derivatives as potent NK1 selective antagonists.
Shue HJ; Chen X; Shih NY; Blythin DJ; Paliwal S; Lin L; Gu D; Schwerdt JH; Shah S; Reichard GA; Piwinski JJ; Duffy RA; Lachowicz JE; Coffin VL; Liu F; Nomeir AA; Morgan CA; Varty GB
Bioorg Med Chem Lett; 2005 Sep; 15(17):3896-9. PubMed ID: 16019209
[TBL] [Abstract][Full Text] [Related]
13. Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.
Ballet S; Feytens D; Buysse K; Chung NN; Lemieux C; Tumati S; Keresztes A; Van Duppen J; Lai J; Varga E; Porreca F; Schiller PW; Vanden Broeck J; Tourwé D
J Med Chem; 2011 Apr; 54(7):2467-76. PubMed ID: 21413804
[TBL] [Abstract][Full Text] [Related]
14. The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist.
Beattie DT; Beresford IJ; Connor HE; Marshall FH; Hawcock AB; Hagan RM; Bowers J; Birch PJ; Ward P
Br J Pharmacol; 1995 Dec; 116(8):3149-57. PubMed ID: 8719789
[TBL] [Abstract][Full Text] [Related]
15. Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists.
Swain CJ; Seward EM; Cascieri MA; Fong TM; Herbert R; MacIntyre DE; Merchant KJ; Owen SN; Owens AP; Sabin V
J Med Chem; 1995 Nov; 38(24):4793-805. PubMed ID: 7490729
[TBL] [Abstract][Full Text] [Related]
16. Characterization of the interaction of diacylpiperazine antagonists with the human neurokinin-1 receptor: identification of a common binding site for structurally dissimilar antagonists.
Cascieri MA; Shiao LL; Mills SG; MacCoss M; Swain CJ; Yu H; Ber E; Sadowski S; Wu MT; Strader CD
Mol Pharmacol; 1995 Apr; 47(4):660-5. PubMed ID: 7536886
[TBL] [Abstract][Full Text] [Related]
17. L-tryptophan urea amides as NK1/NK2 dual antagonists.
Qi H; Shah SK; Cascieri MA; Sadowski SJ; MaCcoss M
Bioorg Med Chem Lett; 1998 Aug; 8(16):2259-62. PubMed ID: 9873524
[TBL] [Abstract][Full Text] [Related]
18. Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.
Katsura Y; Zhang X; Homma K; Rice KC; Calderon SN; Rothman RB; Yamamura HI; Davis P; Flippen-Anderson JL; Xu H; Becketts K; Foltz EJ; Porreca F
J Med Chem; 1997 Aug; 40(18):2936-47. PubMed ID: 9288176
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and in vitro activities of NK-1 antagonists derived from L-tryptophan.
Caliendo G; Fiorino F; Grieco P; Perissutti E; Santagada V; Calignano A; Mancuso F; Albrizio S
Farmaco; 1997 Oct; 52(10):589-93. PubMed ID: 9507670
[TBL] [Abstract][Full Text] [Related]
20. Conformation of the tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 deduced from two-dimensional 1H-NMR and conformational energy calculations is related to its affinity for NK1-receptor.
Millet R; Goossens L; Goossens JF; Chavatte P; Bertrand-Caumont K; Houssin R; Hénichart JP
J Pept Sci; 2001 Jun; 7(6):323-30. PubMed ID: 11461046
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]