These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
162 related articles for article (PubMed ID: 7699713)
1. Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines. Marlowe CK; Selassie CD; Santi DV J Med Chem; 1995 Mar; 38(6):967-72. PubMed ID: 7699713 [TBL] [Abstract][Full Text] [Related]
2. Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis. Hathaway BA; Guo ZR; Hansch C; Delcamp TJ; Susten SS; Freisheim JH J Med Chem; 1984 Feb; 27(2):144-9. PubMed ID: 6694162 [TBL] [Abstract][Full Text] [Related]
3. Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase. Srinivasan B; Tonddast-Navaei S; Skolnick J Eur J Med Chem; 2015 Oct; 103():600-14. PubMed ID: 26414808 [TBL] [Abstract][Full Text] [Related]
4. Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth. Booth RG; Selassie CD; Hansch C; Santi DV J Med Chem; 1987 Jul; 30(7):1218-24. PubMed ID: 3599028 [TBL] [Abstract][Full Text] [Related]
5. Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents. Gangjee A; Shi J; Queener SF; Barrows LR; Kisliuk RL J Med Chem; 1993 Oct; 36(22):3437-43. PubMed ID: 8230134 [TBL] [Abstract][Full Text] [Related]
6. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim. Rosowsky A; Forsch RA; Queener SF J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594 [TBL] [Abstract][Full Text] [Related]
7. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines. Gangjee A; Guo X; Queener SF; Cody V; Galitsky N; Luft JR; Pangborn W J Med Chem; 1998 Apr; 41(8):1263-71. PubMed ID: 9548816 [TBL] [Abstract][Full Text] [Related]
8. Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase. Ma L; Kovacs JA Antimicrob Agents Chemother; 2000 Nov; 44(11):3092-6. PubMed ID: 11036028 [TBL] [Abstract][Full Text] [Related]
9. Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii. Gangjee A; Vasudevan A; Queener SF J Med Chem; 1997 Sep; 40(19):3032-9. PubMed ID: 9301665 [TBL] [Abstract][Full Text] [Related]
10. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. Robson C; Meek MA; Grunwaldt JD; Lambert PA; Queener SF; Schmidt D; Griffin RJ J Med Chem; 1997 Sep; 40(19):3040-8. PubMed ID: 9301666 [TBL] [Abstract][Full Text] [Related]
11. 6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents. Gangjee A; Zhu Y; Queener SF J Med Chem; 1998 Nov; 41(23):4533-41. PubMed ID: 9804692 [TBL] [Abstract][Full Text] [Related]
12. Development of a yeast assay for rapid screening of inhibitors of human-derived Pneumocystis carinii dihydrofolate reductase. Ma L; Jia Q; Kovacs JA Antimicrob Agents Chemother; 2002 Sep; 46(9):3101-3. PubMed ID: 12183283 [TBL] [Abstract][Full Text] [Related]
13. Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Rosowsky A; Hynes JB; Queener SF Antimicrob Agents Chemother; 1995 Jan; 39(1):79-86. PubMed ID: 7695334 [TBL] [Abstract][Full Text] [Related]
14. 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Rosowsky A; Papoulis AT; Queener SF J Med Chem; 1998 Mar; 41(6):913-8. PubMed ID: 9526565 [TBL] [Abstract][Full Text] [Related]
15. Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. Hansch C; Hathaway BA; Guo ZR; Selassie CD; Dietrich SW; Blaney JM; Langridge R; Volz KW; Kaufman BT J Med Chem; 1984 Feb; 27(2):129-43. PubMed ID: 6420569 [TBL] [Abstract][Full Text] [Related]
16. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. Piper JR; Johnson CA; Krauth CA; Carter RL; Hosmer CA; Queener SF; Borotz SE; Pfefferkorn ER J Med Chem; 1996 Mar; 39(6):1271-80. PubMed ID: 8632434 [TBL] [Abstract][Full Text] [Related]
17. Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines. Gangjee A; Adair O; Queener SF J Med Chem; 1999 Jul; 42(13):2447-55. PubMed ID: 10395486 [TBL] [Abstract][Full Text] [Related]
18. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases. Gangjee A; Vasudevan A; Queener SF; Kisliuk RL J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474 [TBL] [Abstract][Full Text] [Related]
19. Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium. Forsch RA; Queener SF; Rosowsky A Bioorg Med Chem Lett; 2004 Apr; 14(7):1811-5. PubMed ID: 15026078 [TBL] [Abstract][Full Text] [Related]
20. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity. Rosowsky A; Forsch RA; Sibley CH; Inderlied CB; Queener SF J Med Chem; 2004 Mar; 47(6):1475-86. PubMed ID: 14998335 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]