BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

217 related articles for article (PubMed ID: 7707373)

  • 21. The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi.
    dos Reis FC; Júdice WA; Juliano MA; Juliano L; Scharfstein J; Lima AP
    FEMS Microbiol Lett; 2006 Jun; 259(2):215-20. PubMed ID: 16734782
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach.
    Hernández Alvarez L; Barreto Gomes DE; Hernández González JE; Pascutti PG
    PLoS One; 2019; 14(1):e0211227. PubMed ID: 30682119
    [TBL] [Abstract][Full Text] [Related]  

  • 23. First quantum mechanics/molecular mechanics studies of the inhibition mechanism of cruzain by peptidyl halomethyl ketones.
    Arafet K; Ferrer S; Moliner V
    Biochemistry; 2015 Jun; 54(21):3381-91. PubMed ID: 25965914
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Novel cruzain inhibitors for the treatment of Chagas' disease.
    Rogers KE; Keränen H; Durrant JD; Ratnam J; Doak A; Arkin MR; McCammon JA
    Chem Biol Drug Des; 2012 Sep; 80(3):398-405. PubMed ID: 22613098
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease.
    Jose Cazzulo J; Stoka V; Turk V
    Curr Pharm Des; 2001 Aug; 7(12):1143-56. PubMed ID: 11472258
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Cruzain structures: apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design.
    Barbosa da Silva E; Dall E; Briza P; Brandstetter H; Ferreira RS
    Acta Crystallogr F Struct Biol Commun; 2019 Jun; 75(Pt 6):419-427. PubMed ID: 31204688
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases.
    Yong V; Schmitz V; Vannier-Santos MA; de Lima AP; Lalmanach G; Juliano L; Gauthier F; Scharfstein J
    Mol Biochem Parasitol; 2000 Jun; 109(1):47-59. PubMed ID: 10924756
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Overexpression of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, is associated with enhanced metacyclogenesis.
    Tomas AM; Miles MA; Kelly JM
    Eur J Biochem; 1997 Mar; 244(2):596-603. PubMed ID: 9119029
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
    Du X; Guo C; Hansell E; Doyle PS; Caffrey CR; Holler TP; McKerrow JH; Cohen FE
    J Med Chem; 2002 Jun; 45(13):2695-707. PubMed ID: 12061873
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Thiosemicarbazone derivatives: Evaluation as cruzipain inhibitors and molecular modeling study of complexes with cruzain.
    Jasinski G; Salas-Sarduy E; Vega D; Fabian L; Martini MF; Moglioni AG
    Bioorg Med Chem; 2022 May; 61():116708. PubMed ID: 35334448
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi.
    Engel JC; Torres C; Hsieh I; Doyle PS; McKerrow JH
    J Cell Sci; 2000 Apr; 113 ( Pt 8)():1345-54. PubMed ID: 10725218
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion.
    Ferrão PM; d'Avila-Levy CM; Araujo-Jorge TC; Degrave WM; Gonçalves Ada S; Garzoni LR; Lima AP; Feige JJ; Bailly S; Mendonça-Lima L; Waghabi MC
    PLoS One; 2015; 10(5):e0124832. PubMed ID: 25938232
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents.
    Ferreira RS; Dessoy MA; Pauli I; Souza ML; Krogh R; Sales AI; Oliva G; Dias LC; Andricopulo AD
    J Med Chem; 2014 Mar; 57(6):2380-92. PubMed ID: 24533839
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.
    Ribeiro JFR; Cianni L; Li C; Warwick TG; de Vita D; Rosini F; Dos Reis Rocho F; Martins FCP; Kenny PW; Lameira J; Leitão A; Emsley J; Montanari CA
    Bioorg Med Chem; 2020 Nov; 28(22):115743. PubMed ID: 33038787
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.
    Roush WR; González FV; McKerrow JH; Hansell E
    Bioorg Med Chem Lett; 1998 Oct; 8(19):2809-12. PubMed ID: 9873627
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Structure-Based Virtual Screening and In Vitro Evaluation of New
    Herrera-Mayorga V; Lara-Ramírez EE; Chacón-Vargas KF; Aguirre-Alvarado C; Rodríguez-Páez L; Alcántara-Farfán V; Cordero-Martínez J; Nogueda-Torres B; Reyes-Espinosa F; Bocanegra-García V; Rivera G
    Int J Mol Sci; 2019 Apr; 20(7):. PubMed ID: 30970549
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of Novel Inhibitors of Cruzain Cysteine Protease of
    Prates JLB; Lopes JR; Chin CM; Ferreira EI; Dos Santos JL; Scarim CB
    Curr Med Chem; 2024; 31(16):2285-2308. PubMed ID: 37888814
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach.
    de Souza ML; de Oliveira Rezende Junior C; Ferreira RS; Espinoza Chávez RM; Ferreira LLG; Slafer BW; Magalhães LG; Krogh R; Oliva G; Cruz FC; Dias LC; Andricopulo AD
    J Chem Inf Model; 2020 Feb; 60(2):1028-1041. PubMed ID: 31765144
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis.
    Huang L; Lee A; Ellman JA
    J Med Chem; 2002 Jan; 45(3):676-84. PubMed ID: 11806719
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment.
    de Albuquerque S; Cianni L; de Vita D; Duque C; Gomes ASM; Gomes P; Laughton C; Leitão A; Montanari CA; Montanari R; Ribeiro JFR; da Silva JS; Teixeira C
    Chem Biol Drug Des; 2020 Sep; 96(3):948-960. PubMed ID: 33058457
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.